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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Glydin on August 5, 2006, at 12:05:10
Anyone use it?
Anyone find it makes you REALLY sleepy after dosing?
I'm using powdered and I like it so far for a number of reasons but I had no idea it would be a producer of such sleepiness.
Posted by dessbee on August 5, 2006, at 12:41:03
In reply to Methylsulfonylmethane (MSM), posted by Glydin on August 5, 2006, at 12:05:10
Methylsulfonylmethane probably works as a methyl donor although it has never been proven. The molecule has two methyl groups so its quite likely that it increases methylation.
Methylation will increase SAME (S-adenosyl methionine) which is involved in synthesis of dopamine, noradrenalin and melatonin. Your sleepiness may be caused by increased melatonin synthesis.
Usually the fatigue will disappear after 2-4 weeks. For others MSM may actually cause insomnia.
Posted by Glydin on August 5, 2006, at 19:49:32
In reply to Re: Methylsulfonylmethane (MSM) » Glydin, posted by dessbee on August 5, 2006, at 12:41:03
Thank you for your response. I do like the effects and the sleepiness isn't a major deal as I take it at night. I did notice some residual drowsiness the next day for a few days but that appears to be waning.
Posted by Racer on August 9, 2006, at 22:02:42
In reply to Thank you, posted by Glydin on August 5, 2006, at 19:49:32
I've taken MSM for several years, and can't tell you anything about fatigue -- I'm half asleep most of my life anyway, thanks to depression and/or antidepressants -- but I can tell you that it does help my joints, and that these days I sleep better than I have in my life. (That's probably unrelated, but it isn't causing insomnia...)
You know, though? It's been so long since I started taking it, I have no clue whether it made me more sedated at the beginning... Mostly, Glydin, I'm only responding to tell you that it has been helpful to me for a long time now, so it's probably worth seeing if the fatigue passes...
Posted by JLx on August 10, 2006, at 15:26:03
In reply to Methylsulfonylmethane (MSM), posted by Glydin on August 5, 2006, at 12:05:10
> Anyone use it?
>
> Anyone find it makes you REALLY sleepy after dosing?
>
> I'm using powdered and I like it so far for a number of reasons but I had no idea it would be a producer of such sleepiness.
>
>I've taken it and have not noticed sleepiness with it.
JL
Posted by dessbee on August 11, 2006, at 15:36:10
In reply to Re: Methylsulfonylmethane (MSM) » Glydin, posted by JLx on August 10, 2006, at 15:26:03
MSM may induce fatigue in the beginning.
Many sites explain it as a detox reaction.
I am not sure if this is the correct explanation but the fatigue is usually transient and may last for up to four weeks. Actually the fatigue is considered a good thing since it is a sign that MSM will have a positive effect.A good thing with MSM is that it is considered very safe, in fact safer than salt. It can be tolerated at high doses.
High doses should preferably be administered in the morning and afternoon since MSM is stimulating when used regularly.
Posted by Declan on August 18, 2006, at 21:30:55
In reply to Re: Methylsulfonylmethane (MSM), posted by dessbee on August 11, 2006, at 15:36:10
It keeps me awake, or rather if I take 1500mg near bedtime I will sleep 3 hours and wake up and that's that for the night. It was thanks to someone here that I guessed it might have been the MSM doing it, and when I took it in the morning I slept much better.
Posted by Glydin on August 19, 2006, at 8:25:38
In reply to Methylsulfonylmethane (MSM), posted by Glydin on August 5, 2006, at 12:05:10
At this point - 3 1/2 weeks in - I feel MSM is
m a y b e not going to be a good choice for me. The sleepiness is still present and is giving way to a bit of lethergy. I also think my mood is taking a hit, nothing awful but noticable to me. Also, strangely, my muscles are more stiff and uncomfortable.I seem to have the weirdest reactions. With "additions", I have responses that have been almost worse than responses to RX stuff.
Oh well....
Thank you all for your sharing.
Posted by dessbee on August 20, 2006, at 9:02:07
In reply to Oh, this is not going that well., posted by Glydin on August 19, 2006, at 8:25:38
How much are you taking?
Usually it is recommended to lower dose if fatigue does not attenuate.
Posted by Glydin on August 20, 2006, at 17:38:33
In reply to Re: Oh, this is not going that well. » Glydin, posted by dessbee on August 20, 2006, at 9:02:07
> How much are you taking?
~~~ Currently, I'm at 3000 mgs. yielding 1,020 mgs. of Organic Sulfur - this is per 1/2 teaspoon of powdered form.
>
> Usually it is recommended to lower dose if fatigue does not attenuate.~~~ Since it's powdered form, it is fairly easy to drop the dose. I could also decrease the frequency thus change the potential peaks and troughs.
I'm not sure what I'm going to do.
Posted by dessbee on August 21, 2006, at 7:44:42
In reply to Re: Oh, this is not going that well. » dessbee, posted by Glydin on August 20, 2006, at 17:38:33
I think you should lower the dose to 1 ml per day and see if these will decrease your fatigue.
Please remember that there are alot of myths around msm telling you to take high doses but the right dose for you may be far less.
I do not recommend taking it at night since MSM may impair sleep and contribute to symptoms of fatigue.Why are you taking MSM?
Posted by Glydin on August 21, 2006, at 17:08:56
In reply to Re: Oh, this is not going that well. » Glydin, posted by dessbee on August 21, 2006, at 7:44:42
> Why are you taking MSM?~~~ I have osteoarthritis issues. I have tried other "stuff" with limited results. I thought I would give this a whirl. Also, it appears to be good for my skin.
Today, I dropped the dose in half and I'll see how that goes as opposed to ditching it. I'm hoping it will be helpful and I'll be able to decrease the untoward effects I'm having.
Posted by dessbee on August 22, 2006, at 9:25:06
In reply to Usage » dessbee, posted by Glydin on August 21, 2006, at 17:08:56
I use it for treating depression.
What I have noticed is that it improves mental clarity, energy level and blood circulation (without worsening rashes or causing hypotension).Side effects that I have noticed at too high doses are fatigue/lethargy, muscle weakness, insomnia and increased sweating.
MSM can be a complicated supplement since the dosage range seems to be extremely wide. Each user has to find out their own optimal dose. Anything from 100mg and 20 gram. Most MSM-sites recommend somewhere between 1-6 gram.
Sometimes it can take several months to reach higher doses due initial side effects like fatigue. For me the upper limit seems to be around 3 gram since higher doses causes insomnia and fatigue.
This is the end of the thread.
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