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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Chinaboy on December 31, 2014, at 22:32:59
Once read from Internet that Amisulpride is a useful add-on treatment of bipolar I at a dosage ranging between 200-800Mg.
Based on the thoery that it is a dopamine agonist at 50-300mg, I feel it might help with bipolar depression?
Thoughts?
Posted by SLS on December 31, 2014, at 23:31:18
In reply to Amisulpride for bipolar depression ?, posted by Chinaboy on December 31, 2014, at 22:32:59
> Once read from Internet that Amisulpride is a useful add-on treatment of bipolar I at a dosage ranging between 200-800Mg.
>
> Based on the thoery that it is a dopamine agonist at 50-300mg, I feel it might help with bipolar depression?
>
> Thoughts?I think the dosage range for amisulpride in the treatment of depression or dysthymia is 25 - 100 mg/day. Amisulpride is a dopamine antagonist that is preferential to presynaptic autoreceptors at low dosages. Blocking these receptors ends up being pro-dopaminergic because it signals the neuron to manufacture and release more dopamine via a negative feedback loop.
If you decide to try amisulpride, I would be grateful if you would report your results.
Thanks.
- Scott
Posted by b2chica on January 1, 2015, at 15:06:08
In reply to Amisulpride for bipolar depression ?, posted by Chinaboy on December 31, 2014, at 22:32:59
why isnt this med FDA approved in US??? i just dont understand.
since it is a DA i really feel this would be an absolute perfect option for me.
i wish there were something i could do...
Posted by SLS on January 1, 2015, at 16:50:53
In reply to Re: Amisulpride for bipolar depression ? PLEASE, posted by b2chica on January 1, 2015, at 15:06:08
> why isnt this med FDA approved in US??? i just dont understand.
> since it is a DA i really feel this would be an absolute perfect option for me.
> i wish there were something i could do...
>Have you tried Abilify (aripiprazole)? If so, how did you respond to it?
Focalin (dexmethylphenidate), a special type of Ritalin, might help you as a temporary measure or PRN to help you get through your most difficult times. It inhibits the reuptake of dopamine.
- Scott
Posted by Chinaboy on January 1, 2015, at 21:15:24
In reply to Re: Amisulpride for bipolar depression ? » Chinaboy, posted by SLS on December 31, 2014, at 23:31:18
I think the dosage range for amisulpride in the treatment of depression or dysthymia is 25 - 100 mg/day. Amisulpride is a dopamine antagonist that is preferential to presynaptic autoreceptors at low dosages. Blocking these receptors ends up being pro-dopaminergic because it signals the neuron to manufacture and release more dopamine via a negative feedback loop.
>
> If you decide to try amisulpride, I would be grateful if you would report your results.
>
> Thanks.> - Scott
I feel Amisulpride can be extremely effective yet extremely unpredictable.
The lower doses never worked for me. Been on it numerous times, and failed it numerous times. This time at 100mg, feeling motivated on the third day.
The effect may eventually disappear? What should I do then?
Posted by Chinaboy on January 1, 2015, at 21:27:02
In reply to Re: Amisulpride for bipolar depression ? PLEASE » b2chica, posted by SLS on January 1, 2015, at 16:50:53
> Have you tried If so, h> -
Dear Scott
Could you please share your knowledge about Abilify (aripiprazole)?
Thank you in advance!
(I remember you are on it for bipolar depression. But how much do you know about it being used as dopamine agonist for motivation and ahedonia?)
Posted by b2chica on January 1, 2015, at 23:30:10
In reply to Re: Amisulpride for bipolar depression ? PLEASE » b2chica, posted by SLS on January 1, 2015, at 16:50:53
ya, i had a bad reaction to abilify. i got very violent... almost lost my T because i had an 'episode' in her office... course i showed up drunk as well. ya, wasn't good. but i do remember that i was up to 10mg of abilify and at some point i remember someone stating the benefits of low dose vs. higher dose of abilify for folks, but i dont remember what the low dose was better for and what the high dose was better for... do you remember?
maybe i was on too high, too low dose? i would certainly be willing to try it again.
i have not been on Focalin, but i have been on Ritalin and ritalin LA, neither one helped well. and i crashed from it. Adderall is WAY better for me. and uually is enough.
although now i've seemed to just stop taking it in the afternon. i'm Sure its making my depression worse (as i take it more for my depression than ADHD). But my pdoc insisted i at least try it (again). before our appt next friday.
yes my appt Finally got bumped... it was probably cuz i broke down while on the phgone withe the nurse.. talking about, well you now. offing myself.
Dopamine agonist (adderall) seems to help me most. thats' why i WISH they would allow amisulpride... it read that it was a DA.
are there any other meds that are DA that i could try??Thanks much for your input Scott!
b2c
> Have you tried Abilify (aripiprazole)? If so, how did you respond to it?
>
> Focalin (dexmethylphenidate), a special type of Ritalin, might help you as a temporary measure or PRN to help you get through your most difficult times. It inhibits the reuptake of dopamine.
>
>
> - Scott
Posted by b2chica on January 1, 2015, at 23:32:08
In reply to feeling motivated on the third day, posted by Chinaboy on January 1, 2015, at 21:15:24
so is amulsipride a dopamine agonist or antagonist? i must have read that website incorrectly the other night.
thanks
b2c
Posted by burial on January 2, 2015, at 19:05:47
In reply to Re: feeling motivated on the third day, posted by b2chica on January 1, 2015, at 23:32:08
i have bipolar disorder and have taken amisulpride before. It definitely did "something", i was full of energy to a point i couldn't sleep, but still had the energy the next morning. I can see how it can help bipolar depression. I think what makes this drug unique is that it has some interesting things related to D2 post and pre synaptic receptors, preferring the latter. It seems it's pro dopaminergic even at higher doses, i took 600mg
Posted by b2chica on January 3, 2015, at 3:22:06
In reply to Re: feeling motivated on the third day, posted by burial on January 2, 2015, at 19:05:47
interesting.
is there anything in the U.S. that is FDA approved similar to this?
Posted by burial on January 3, 2015, at 10:14:04
In reply to Re: feeling motivated on the third day, posted by b2chica on January 3, 2015, at 3:22:06
the closest one i think would be flupentixol, a typical antipsychotic. I think it has some presynaptic autoreceptor properties, it was a bit activating for me, i even took it in the mornings
Posted by SLS on January 3, 2015, at 11:00:11
In reply to feeling motivated on the third day, posted by Chinaboy on January 1, 2015, at 21:15:24
> I think the dosage range for amisulpride in the treatment of depression or dysthymia is 25 - 100 mg/day. Amisulpride is a dopamine antagonist that is preferential to presynaptic autoreceptors at low dosages. Blocking these receptors ends up being pro-dopaminergic because it signals the neuron to manufacture and release more dopamine via a negative feedback loop.
> >
> > If you decide to try amisulpride, I would be grateful if you would report your results.
> >
> > Thanks.
>
> > - Scott
>
> I feel Amisulpride can be extremely effective yet extremely unpredictable.
>
> The lower doses never worked for me. Been on it numerous times, and failed it numerous times. This time at 100mg, feeling motivated on the third day.
>
> The effect may eventually disappear? What should I do then?That is a question that if I could answer, I would have authored a textbook by now. Sometimes, drugs surprise me. They work when I never thought they would.
You might consider adding Parnate to help prevent dopamine breakdown. Also, Lamictal might be pro-dopaminergic indirectly through the inhibition of certain glutamate tracts leading to the pleasure centers of the limbic system.
I think my bipolar depression has a dopaminergic component, but it is not clear to me whether this is a primary site of dysfunction or a secondary imbalance resulting from pathologies located upstream.
If amisulpiride or sulpiride make you feel better, even if only briefly, that could represent a clue as to which treatments to pursue. I responded for a day or two to sulpiride, and ultimately went on to glean a more stable improvement from Abilify. You might want to research a drug named cariprazine. I should be out soon. Cariprazine is an analog of Abilify, but has stonger effects in the limbic system because it prefers to bind to D3 dopamine receptors. I'll probably want to try it myself.
- Scott
Posted by Chinaboy on January 9, 2015, at 6:26:15
In reply to Re: feeling motivated on the third day, posted by SLS on January 3, 2015, at 11:00:11
Hi,there. Talked to my pdoc,and he said that 100mg of Amisulpride (Solian) is added to the combo (200mg of Lamictal,10mg of Abilify) for the purpose of tackling some minor negative symptoms from schizoid personality disorder.
Now I feel much better. Didn't know whether Amisulpride (Solian) contributed to the improvement or not.
Posted by burial on January 9, 2015, at 8:04:42
In reply to Amisulpride for schizoid personality disorder, posted by Chinaboy on January 9, 2015, at 6:26:15
> Hi,there. Talked to my pdoc,and he said that 100mg of Amisulpride (Solian) is added to the combo (200mg of Lamictal,10mg of Abilify) for the purpose of tackling some minor negative symptoms from schizoid personality disorder.
>
> Now I feel much better. Didn't know whether Amisulpride (Solian) contributed to the improvement or not.
good to hear, that you're doing fine. I think i've seen amisulpride augmentation of clozapine for negative symptoms with excellent results.
Posted by B2chica on January 25, 2015, at 22:19:12
In reply to Re: Amisulpride for schizoid personality disorder, posted by burial on January 9, 2015, at 8:04:42
why is none of this available in the US???
amulsipride, Flupentixol.... arrrghhh... Sooo frustrating!by the way, just saw this on the ccariprazine...
http://www.drugs.com/nda/cariprazine_150120.html
Richter and Actavis Announce Positive Phase III Results for Cariprazine in the Prevention of Relapse in Patients with Schizophrenia
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