Posted by SLS on January 3, 2015, at 11:00:11
In reply to feeling motivated on the third day, posted by Chinaboy on January 1, 2015, at 21:15:24
> I think the dosage range for amisulpride in the treatment of depression or dysthymia is 25 - 100 mg/day. Amisulpride is a dopamine antagonist that is preferential to presynaptic autoreceptors at low dosages. Blocking these receptors ends up being pro-dopaminergic because it signals the neuron to manufacture and release more dopamine via a negative feedback loop.
> >
> > If you decide to try amisulpride, I would be grateful if you would report your results.
> >
> > Thanks.
>
> > - Scott
>
> I feel Amisulpride can be extremely effective yet extremely unpredictable.
>
> The lower doses never worked for me. Been on it numerous times, and failed it numerous times. This time at 100mg, feeling motivated on the third day.
>
> The effect may eventually disappear? What should I do then?That is a question that if I could answer, I would have authored a textbook by now. Sometimes, drugs surprise me. They work when I never thought they would.
You might consider adding Parnate to help prevent dopamine breakdown. Also, Lamictal might be pro-dopaminergic indirectly through the inhibition of certain glutamate tracts leading to the pleasure centers of the limbic system.
I think my bipolar depression has a dopaminergic component, but it is not clear to me whether this is a primary site of dysfunction or a secondary imbalance resulting from pathologies located upstream.
If amisulpiride or sulpiride make you feel better, even if only briefly, that could represent a clue as to which treatments to pursue. I responded for a day or two to sulpiride, and ultimately went on to glean a more stable improvement from Abilify. You might want to research a drug named cariprazine. I should be out soon. Cariprazine is an analog of Abilify, but has stonger effects in the limbic system because it prefers to bind to D3 dopamine receptors. I'll probably want to try it myself.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1074654
URL: http://www.dr-bob.org/babble/20150102/msgs/1074757.html