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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by neo on November 6, 2009, at 10:52:35
Hi to every! and excuse my bad English too.
Rarely on this board, Amisulpride is treated, I think it's cause the drug is not approved for US market, but i'm not sure and i could wrong.
Anyway, in UE is used a lot, so i try to share my personal experience, because at the end it's a positive experience.
For a distymic desease (aphaty, anergie, lack on motivation and low mood) i was on Every drug on the market. The results were "nothing" or more frequently a worsening of my situation.
Only Amisulpride gave me from the beginning the feeling that "something is happening": More energized but calm, lifting of the mood, desire of "doing" a lot of things, to contact people, to speak and less troubles in my mind. The sensation i had is that the "problems" become "chances".
From the bad side, i noticed that if i took Amis every day, from the third day the effect reduced greatly and a sort of somnolence or brain fog appeared.
So i discovered that taking it every other day (day-in/day-out) the right effect appeared again, but unfortunely it not lasts for all the 48 hours.
I was not able to find out a schedule working better: taking every 36 hours will reproduce the same bad (i call them "neuroleptic") effects.
I used different dosage from 10 to 200 mg, but the diffence was not so great, and at the end found out that 25 mg is for me the best dosage.
Anyway, amisulpride helped me a lot, even if the effect never lasts continuously!
Never reported very significant side effects: a slight increase of appetite, a litte more difficulty to sleep, and, strange, a mild lift of sexual desire and efficency (so i suppose that my Prolctine is still normal) and other less importantant sides.
This is in few words my experience (and surely I forgot a lot..) but if someone is interested to know something else or have to share own experience, please do it!
Thank you very much for your attention!
Bye
Neo.
Posted by TenMan on November 6, 2009, at 11:00:59
In reply to AMISULPRIDE: my 4 years experience., posted by neo on November 6, 2009, at 10:52:35
Glad to hear you are getting good results!
Amisulpride is one of those medicines that I really wish we had available over here. I personally tried it years ago in low doses of 25-50mgs. where it supposedly preferentially agonizes the presynaptic receptor and increases net dopamine firing. I had pretty good results overall but I did find that it moved my prolactin above the normal range. Other than that it was a good and effective medication for my symptoms. Unfortunately the cost and difficulty obtaining it from overseas sources prohibited me from using it long term.
Posted by Phillipa on November 6, 2009, at 12:38:29
In reply to Re: AMISULPRIDE: my 4 years experience., posted by TenMan on November 6, 2009, at 11:00:59
So it's activating? Phillipa
Posted by neo on November 6, 2009, at 13:52:17
In reply to Re: AMISULPRIDE: my 4 years experience., posted by TenMan on November 6, 2009, at 11:00:59
Hi TenMan and Phillipa,
>>I really wish we had available over here<<
So it's not still spproved by FDA? mmm... I supposed! Hope it will be soon!
Yes, rise of prolactine (in long continuated use) is normal. When i used it day by day i have this side (very disturbing) too.
It began after a couple of weeks of continuative usage.
Unfortunely cost is a great problem too, but using Solian 200 mg pills, and cutting them into 8 (of 4) the cost is reduced. But i don't know how much are the costs of forwarding...>>So it's activating?<<
Yes Phillipa, in my case and at 25mg dosage, Amis have on me a very good activating profile.
Bye
Neo
Posted by bulldog2 on November 6, 2009, at 14:12:12
In reply to Re: AMISULPRIDE: my 4 years experience., posted by TenMan on November 6, 2009, at 11:00:59
> Glad to hear you are getting good results!
>
> Amisulpride is one of those medicines that I really wish we had available over here. I personally tried it years ago in low doses of 25-50mgs. where it supposedly preferentially agonizes the presynaptic receptor and increases net dopamine firing. I had pretty good results overall but I did find that it moved my prolactin above the normal range. Other than that it was a good and effective medication for my symptoms. Unfortunately the cost and difficulty obtaining it from overseas sources prohibited me from using it long term.I have heard about the higher prolactin. Would meds that lower prolactin destroy the good properties of amisulpride?
Posted by bleauberry on November 6, 2009, at 16:58:10
In reply to AMISULPRIDE: my 4 years experience., posted by neo on November 6, 2009, at 10:52:35
I have tried amisulpride several times. The longest I think was about 3 weeks. Usually by the end of the first week I run into serious sexual problems, most surely the increased prolactin thing.
The feelings you described are the same I felt. A smooth stimulation, increased interest, brighter outlook, slightly increased appetite (good for me), lighter sleep, clear thinking, and rather calm and comfortable the whole time. Almost like antidepressant and antianxiety at the same time, that kicks in real fast. Actually I think the phrase "mood brightener" is more accurate than "antidepressant" when talking about amisulpride.
I am really glad you shared your dosing strategy because I find that extremely helpful and meaningful. I might just have to pull some of my old stash out and try that. I never would have thought of taking it every other day, but what a creative and positive idea.
As with you, I discovered my best dose was 25mg.
To anyone else on this thread...while amisulpride is not a USA medication, it is legally and easily available to those who know how to do google searches.
Posted by TenMan on November 6, 2009, at 17:23:25
In reply to Re: AMISULPRIDE: my 4 years experience. » TenMan, posted by bulldog2 on November 6, 2009, at 14:12:12
> > Glad to hear you are getting good results!
> >
> > Amisulpride is one of those medicines that I really wish we had available over here. I personally tried it years ago in low doses of 25-50mgs. where it supposedly preferentially agonizes the presynaptic receptor and increases net dopamine firing. I had pretty good results overall but I did find that it moved my prolactin above the normal range. Other than that it was a good and effective medication for my symptoms. Unfortunately the cost and difficulty obtaining it from overseas sources prohibited me from using it long term.
>
> I have heard about the higher prolactin. Would meds that lower prolactin destroy the good properties of amisulpride?That's a good question. I remember someone once mentioned adding bromocriptine to amisulpride to reduce the prolactin but I don't know of anyone who has ever tried the combination. It seems to me it might work since bromocriptine seems to be a pretty selective dopamine agonist at receptors that deal primarily with the release of hormones like prolactin and GH from the pituitary and less so at other dopamine receptors involved in mood and energy. It would be interesting to hear of a user report on such a combination.
Posted by neo on November 6, 2009, at 18:37:14
In reply to Re: AMISULPRIDE: my 4 years experience., posted by bleauberry on November 6, 2009, at 16:58:10
Hi Bleauberry, glad to meet you again!
We were discussing many times a lot of years ago about the same matter. -sulpirides and dopamine "lifters".
As you can see, despite of years of usage, i was not able to find out a way to use Amis continuosly without sides.
But Amis is my only chance and so i have to go on with it.>>Usually by the end of the first week I run into serious sexual problems, most surely the increased prolactin thing.<<
Yes. I think so! My experience is the same.
>>Almost like antidepressant and antianxiety at the same time, that kicks in real fast. Actually I think the phrase "mood brightener" is more accurate than "antidepressant"<<
Completely in accordance. I use to say "i feel fine" (calm but sharp) and i never remember to have felt this when i was using Ssri/Snri tca benzos... there was always something that was numbing my mind.
>>I might just have to pull some of my old stash out and try that. I never would have thought of taking it every other day<<
The experience in the use and what i have read about, made me think to try something like that. Solian's producers say:
" Elimination is rapid during the first 24 hours (T½ = 2 to 3 hours) with excretion of 80 to 98% of the total quantity excreted. Elimination slows after 24 hours (T½ = 12 to 19 hours)."
So i thought that during the first assumption, the drug leaves the body so quickly to avoid "neuroleptic" sides (not bind post-synaptic receptors? don't know, it should be dose-related!) and the body not reacts to the substance, but giving anyway a lift in dopamine level (bind only pre-syn. receptors?).
Anyway, the problems and sides appear only in consequence to the 2nd assumption.
On the other side, i was never able to make it work continuosly for 2 days because the effect fades after about 30 hours.Good luck for your test, and let me know your impressions.
Bye!
Neo
Posted by neo on November 6, 2009, at 18:57:12
In reply to Re: AMISULPRIDE: my 4 years experience., posted by TenMan on November 6, 2009, at 17:23:25
I have tryed it when i was taking Amisulpride continuosly.
I have added firstly Bromocriptine and later switched to Cabergoline.
I think that Bromoc. and Caber. do not affect directly the right properties of amisulpride.
But these two substance have given to me somnolence and dizzyness and so, indirectly, reduced a lot the Amisulpride efficacy. Yes, i think that those substances bind other dopamine receptors not involved in mood and energy.
Bromoc. more than Caberg., reduced a lot my level of prolactine until the normal level, and restored normal sexual efficiency.
Posted by bleauberry on November 6, 2009, at 18:58:36
In reply to Re: AMISULPRIDE: my 4 years experience. » bleauberry, posted by neo on November 6, 2009, at 18:37:14
An idea just now popped into my head.
You generally implied that the every-other-day dosage of amisulpride serves to gently increase dopamine function while avoiding the neuroleptic sides.
A very similar strategy that has proved useful in many disease is Low Dose Naltrexone, which is a mere 1.5mg-4.5mg taken at bedtime, which temporarily blocks the opioid receptors for a few hours, causing a stimulation of more natural opioids.
Low dose naltrexone plus every-other-day amisulpride to raise both opioids and dopamine? Hmmm. Now that might be something.
My short trial of LDN seemed to be anti-prolactin, or at the very least, strongly pro-sexual desire and ability.
> Hi Bleauberry, glad to meet you again!
> We were discussing many times a lot of years ago about the same matter. -sulpirides and dopamine "lifters".
> As you can see, despite of years of usage, i was not able to find out a way to use Amis continuosly without sides.
> But Amis is my only chance and so i have to go on with it.
>
> >>Usually by the end of the first week I run into serious sexual problems, most surely the increased prolactin thing.<<
>
> Yes. I think so! My experience is the same.
>
> >>Almost like antidepressant and antianxiety at the same time, that kicks in real fast. Actually I think the phrase "mood brightener" is more accurate than "antidepressant"<<
>
> Completely in accordance. I use to say "i feel fine" (calm but sharp) and i never remember to have felt this when i was using Ssri/Snri tca benzos... there was always something that was numbing my mind.
>
> >>I might just have to pull some of my old stash out and try that. I never would have thought of taking it every other day<<
>
> The experience in the use and what i have read about, made me think to try something like that. Solian's producers say:
> " Elimination is rapid during the first 24 hours (T½ = 2 to 3 hours) with excretion of 80 to 98% of the total quantity excreted. Elimination slows after 24 hours (T½ = 12 to 19 hours)."
> So i thought that during the first assumption, the drug leaves the body so quickly to avoid "neuroleptic" sides (not bind post-synaptic receptors? don't know, it should be dose-related!) and the body not reacts to the substance, but giving anyway a lift in dopamine level (bind only pre-syn. receptors?).
> Anyway, the problems and sides appear only in consequence to the 2nd assumption.
> On the other side, i was never able to make it work continuosly for 2 days because the effect fades after about 30 hours.
>
> Good luck for your test, and let me know your impressions.
> Bye!
> Neo
>
>
Posted by neo on November 6, 2009, at 19:59:09
In reply to Re: AMISULPRIDE: my 4 years experience. » neo, posted by bleauberry on November 6, 2009, at 18:58:36
>> You generally implied that the every-other-day dosage of amisulpride serves to gently increase dopamine function while avoiding the neuroleptic sides.<<
Perfect! It is exactly what i was thinking.
The problem is one: I take Amis in the morning after breakfast. In the early afternoon of the next day the right effect disappears. At this moment the drug is already completely out of the body.
So i'm "uncovered" for about 12 hours (till the morning after).
How to prolong the effect (receptor binding?) without a new assumption of Amis? Really don't know. If you have any idea, let me know it!
>> Low dose naltrexone plus every-other-day amisulpride to raise both opioids and dopamine? Hmmm. Now that might be something. <<Yes! It seems quite the same strategy! Opioids and dopamine receptors work in the same way? Could be!
Sincerely, never heard before Naltrexone, so i think you can deduce better than me.
Bye
Neo
Posted by delna on November 10, 2009, at 16:43:43
In reply to AMISULPRIDE: my 4 years experience., posted by neo on November 6, 2009, at 10:52:35
Wow, thanks for sharing this.
This drug sounds so tempting and quite perfect for me!
But I have to keep away from anti-psychotics for a while.
TC
D
Posted by neo on November 10, 2009, at 16:53:58
In reply to Re: AMISULPRIDE: my 4 years experience. » neo, posted by delna on November 10, 2009, at 16:43:43
Hi, Delna
hmmm.... but i really think that Amis at these very low dosages hasn't an anti-psychotic profile at all.
Anyway, let us know something if you'll try it.
Bye.
Neo
Posted by neo on November 27, 2009, at 9:51:52
In reply to Re: AMISULPRIDE: my 4 years experience. » neo, posted by bleauberry on November 6, 2009, at 18:58:36
Hi bleauberry,
another idea:
from Solian's producer: "Concomitant administration with food changed the absorption profile so that the drug showed only one absorption peak"
But they do not say if half-lives, in this case, changes.
I've tested that using Amisulrpide at empty stomach (1 h before or 3 hs or more after meals) seems to work longer.
But I've no idea if taking a drug with food, increase or reduce its half-lives.
Any ideas about it?
Bye!
This is the end of the thread.
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