Posted by bleauberry on November 6, 2009, at 18:58:36
In reply to Re: AMISULPRIDE: my 4 years experience. » bleauberry, posted by neo on November 6, 2009, at 18:37:14
An idea just now popped into my head.
You generally implied that the every-other-day dosage of amisulpride serves to gently increase dopamine function while avoiding the neuroleptic sides.
A very similar strategy that has proved useful in many disease is Low Dose Naltrexone, which is a mere 1.5mg-4.5mg taken at bedtime, which temporarily blocks the opioid receptors for a few hours, causing a stimulation of more natural opioids.
Low dose naltrexone plus every-other-day amisulpride to raise both opioids and dopamine? Hmmm. Now that might be something.
My short trial of LDN seemed to be anti-prolactin, or at the very least, strongly pro-sexual desire and ability.
> Hi Bleauberry, glad to meet you again!
> We were discussing many times a lot of years ago about the same matter. -sulpirides and dopamine "lifters".
> As you can see, despite of years of usage, i was not able to find out a way to use Amis continuosly without sides.
> But Amis is my only chance and so i have to go on with it.
>
> >>Usually by the end of the first week I run into serious sexual problems, most surely the increased prolactin thing.<<
>
> Yes. I think so! My experience is the same.
>
> >>Almost like antidepressant and antianxiety at the same time, that kicks in real fast. Actually I think the phrase "mood brightener" is more accurate than "antidepressant"<<
>
> Completely in accordance. I use to say "i feel fine" (calm but sharp) and i never remember to have felt this when i was using Ssri/Snri tca benzos... there was always something that was numbing my mind.
>
> >>I might just have to pull some of my old stash out and try that. I never would have thought of taking it every other day<<
>
> The experience in the use and what i have read about, made me think to try something like that. Solian's producers say:
> " Elimination is rapid during the first 24 hours (T½ = 2 to 3 hours) with excretion of 80 to 98% of the total quantity excreted. Elimination slows after 24 hours (T½ = 12 to 19 hours)."
> So i thought that during the first assumption, the drug leaves the body so quickly to avoid "neuroleptic" sides (not bind post-synaptic receptors? don't know, it should be dose-related!) and the body not reacts to the substance, but giving anyway a lift in dopamine level (bind only pre-syn. receptors?).
> Anyway, the problems and sides appear only in consequence to the 2nd assumption.
> On the other side, i was never able to make it work continuosly for 2 days because the effect fades after about 30 hours.
>
> Good luck for your test, and let me know your impressions.
> Bye!
> Neo
>
>
poster:bleauberry
thread:924718
URL: http://www.dr-bob.org/babble/20091029/msgs/924786.html