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Dr. Bob is Robert Hsiung, MD,
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Posted by SLS on April 13, 2006, at 8:20:01
Pregabalin (Lyrica) for Generalized Anxiety Disorder in EUOn March 27, the European Commission (EC) approved a new indication for pregabalin (Lyrica capsules, made by Pfizer, Inc), allowing its use for the treatment of generalized anxiety disorder (GAD) in the European Union.
The approval was based on a review of data from 5 randomized, double-blind clinical trials in more than 2000 patients showing that pregabalin provided rapid and sustained efficacy in treating GAD, yielding significant relief from psychic and somatic symptoms within the first week of treatment.
The majority of adverse events related to pregabalin use were mild to moderate in intensity and generally dose-related. Dizziness and drowsiness were most frequently reported.
Pregabalin was previously approved by the EC and the US Food and Drug Administration for the management of diabetic peripheral neuropathy, postherpetic neuralgia, and adjunctive treatment of partial-onset seizures.
Posted by Sobriquet Style on April 13, 2006, at 9:46:03
In reply to Lyrica (pregabalin) for GAD approved in Europe, posted by SLS on April 13, 2006, at 8:20:01
Posted by Sobriquet Style on April 13, 2006, at 9:58:27
In reply to Lyrica (pregabalin) for GAD approved in Europe, posted by SLS on April 13, 2006, at 8:20:01
So, what are the key differences between Pregabalin and Gabapentin?
Pro's and Con's; - Lyrica vs Neuronitn for anxiety with/without pre-existing mental disorders eg Bipolar disorder. Has Gabapentin got more value in use with anxiety associated with bipolar compared with Lyrica? (Even though Gabapentins value isn't too high anyway) Its it too early to know? Anyone have personal experience?
Anyone like to add any comments? I know little about the differences but have had my eye on Lyrica for a while now. I take Neurontin, for anxiety and bipolar and like the drug very much, perhaps for that reason theres no need to change it. Plus with the addition of Valium I think my anxiety will be well under control. However sometimes I feel Neurontin can lack power. Therefore lyrica being a more powerful substance, at some stage I may try it.
Would one have less side effects, theoretically, compared to the other?
What are the dosage equivalents? 300mg of Gabapentin = ?
~
Posted by Tom Twilight on April 13, 2006, at 13:08:13
In reply to Key Features of Lyrica vs Neurontin., posted by Sobriquet Style on April 13, 2006, at 9:58:27
I wonder how they got that one though
Lyrica gave me a strong anti-anxiety effect to begin with, but I rapidly developed tollerance, and it ended up making more anxious!
Did I start with to high a dose maybe?
Posted by james_glasgow on April 13, 2006, at 14:01:23
In reply to Lyrica Approved for GAD?-Bizare, posted by Tom Twilight on April 13, 2006, at 13:08:13
> I wonder how they got that one though
>
> Lyrica gave me a strong anti-anxiety effect to begin with, but I rapidly developed tollerance, and it ended up making more anxious!
>
> Did I start with to high a dose maybe?I spoke to the medical information department of Pfizer UK on Tuesday and they told me they are just in the process of writing the up-to-date SPC which will be available on the electronic medicines compendium within a week. This will tell you what their recommended doses are for GAD.
James
Posted by Sobriquet Style on April 13, 2006, at 14:33:21
In reply to Lyrica Approved for GAD?-Bizare, posted by Tom Twilight on April 13, 2006, at 13:08:13
>Lyrica gave me a strong anti-anxiety effect to begin with, but I rapidly developed tollerance, and it ended up making more anxious!
I wonder if Lyrica has more potential to poop out, compared with the anti anxiety effects of Neurontin?
~
Posted by platinumbride on April 16, 2006, at 12:02:28
In reply to Re: Lyrica Approved for GAD?-Bizare, posted by Sobriquet Style on April 13, 2006, at 14:33:21
What a laugh...
We all respond differently.For me it is neurontin that poops out!
And that is making me so very uncomfortable....
It poops out, I raise the dose and then I am at doses exceeding 8000mgs/day.
Diane
> >Lyrica gave me a strong anti-anxiety effect to begin with, but I rapidly developed tollerance, and it ended up making more anxious!
>
> I wonder if Lyrica has more potential to poop out, compared with the anti anxiety effects of Neurontin?
>
> ~
Posted by yxibow on April 19, 2006, at 1:40:17
In reply to Key Features of Lyrica vs Neurontin., posted by Sobriquet Style on April 13, 2006, at 9:58:27
> So, what are the key differences between Pregabalin and Gabapentin?
They work through different ion channels though they both hit one transmitter the same. Gapapentin is an isomer of GABA, Pregabalin's structure is different though somewhat related.
I'm stepping out on the brave new world of Lyrica tonight...
> Anyone like to add any comments? I know little about the differences but have had my eye on Lyrica for a while now.
The eye, ironically is my main concern -- up to 10 % of people have reported blurry vision and other visual aberrations from a to z.
About the same or less have some slight weight gain but not like other major suspects.
> What are the dosage equivalents? 300mg of Gabapentin =Its hard to say -- Gabapentin is non-linear, and eliminates from the body if a dose is over 900 or so at a time. Lyrica is almost completely linear, and more powerful, so perhaps less is needed.
It is approved in the US only for Diabetic Neuropathic Pain, Shingles Neuropathic Pain, and Adjunctive Treatment for Partial Onset Seizures in Adults.
However it is slowly being used to see if it will act as Neurontin does as a mood stabilizer / anxiolytic.
It was going to be slapped with a C-IV in the US and is now C-V, one of a very few set of medications that are C-V... most C-V medications really are almost un-categorized. The meth craze in the midwest let one of those states to slap C-V on Sudafed so you have to obtain a prescription which is totally stupid. (And Sudafed PE does not work.) Anyway, that issue seems to be more resolved that Federally, Sudafed cannot be sold more than 3.6 grams a day. Of course in a big city methheads can shop at different pharmacies. But the problem is more in rural america so maybe that will change. Who knows. Anyway that's off topic.
I think I am experiencing a minor feeling in the eye at 25mg though that could just be a placebo effect or that its late at night. I'm going very very slow on it because my doctor thinks I am near a GABA limit with Neurontin and if you have too much GABA going around it can also cause seizures.
Tidings
-- J
Posted by Sobriquet Style on April 20, 2006, at 7:14:36
In reply to Re: Key Features of Lyrica vs Neurontin. » Sobriquet Style, posted by yxibow on April 19, 2006, at 1:40:17
>The eye, ironically is my main concern -- up to 10 % of people have reported blurry vision and other visual aberrations from a to z.
I think my vision does get slightly effected by Neurontin. But strange enough, and as strange as the drug is, I quite enjoy the experience. Objects and colours seem brighter, kind of like a strange anti depressant effect.>About the same or less have some slight weight gain but not like other major suspects.
I wonder how the weightgain differs from Gabapentin ~ if whether you gain from Gabapentin, I do, you may gain more, from Pregabalin for example with roughly equivalent dosages..
>It was going to be slapped with a C-IV in the US and is now C-V
Thats is very interesting..
>I'm stepping out on the brave new world of Lyrica tonight...
Best of luck. Let me know how it goes. :-)
I think both Neurontin and Pregabalin in combination with benzo's is a supurb mix for anxiety.
~
Posted by Sobriquet Style on April 20, 2006, at 7:23:19
In reply to Re: Lyrica Approved for GAD?-Bizare, posted by platinumbride on April 16, 2006, at 12:02:28
>For me it is neurontin that poops out!
This has happened to me at times too - although the effect always come back, sometimes really strong! It is a very strange drug. I keep my dosage around the 900mg mark. Although depending on how i'm feeling, I'll sometimes reduce it by 300mg, depending on how i'm feeling. I once reduced by 600mg. When I increase, wow, the effects come back pretty good. It can be a balancing act at times, but now I've been doing well with it the past few months, probably better than I did when I first started it along time ago.
>I am at doses exceeding 8000mgs/day.
That is one hell of a high dosage!
Do you take the generic or Brand Neurontin? I first took Brand, then got switched to Generic. I did Generic for a while but always thought it was slightly weaker. So then I changed back to Brand - it made quite a difference indeed, felt alot more potent. Definitely not a placebo effect.. If you're on generic and you havent been on brand, it "may" help alittle more. Plus, you may find its actually cheaper than the generic!
~
Posted by platinumbride on April 20, 2006, at 11:38:33
In reply to Re: Key Features of Lyrica vs Neurontin., posted by Sobriquet Style on April 20, 2006, at 7:14:36
I wish I could say that benzos and neurontin were superb for anxiety :(.
i think akathisia is making things pretty bad too.
There seems to be nothing I can take for it. No cogentin, amantadine or inderall. They all have bad side effects for me :(.
I'm waiting for my doc to come up with something. He is inclined toward baclafan (sp). Or at least he was. Sigh.....
Diane
Posted by zeugma on April 20, 2006, at 11:51:46
In reply to Re: Key Features of Lyrica vs Neurontin., posted by platinumbride on April 20, 2006, at 11:38:33
> I wish I could say that benzos and neurontin were superb for anxiety :(.
>
> i think akathisia is making things pretty bad too.
>
> There seems to be nothing I can take for it. No cogentin, amantadine or inderall. They all have bad side effects for me :(.>>I think Provigil is actually good for akathesia (based on my own experience at least).
Have you ever tried Provigil?
-z
>
Posted by platinumbride on April 20, 2006, at 13:16:04
In reply to Re: Key Features of Lyrica vs Neurontin. » platinumbride, posted by zeugma on April 20, 2006, at 11:51:46
No, but I will look into it.
Thank you so much.
diane
Posted by Sobriquet Style on April 20, 2006, at 18:09:50
In reply to Re: Key Features of Lyrica vs Neurontin., posted by platinumbride on April 20, 2006, at 11:38:33
Posted by platinumbride on April 21, 2006, at 6:09:25
In reply to Hope you find you relief soon.. (nm) » platinumbride, posted by Sobriquet Style on April 20, 2006, at 18:09:50
T
This is the end of the thread.
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