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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by SLS on February 3, 2022, at 9:48:46
Hi, All.
I can't believe my lack of imagination that this idea never occurred to me and that this article escaped me for 22 years.
"Combined treatment with venlafaxine and tricyclic antidepressants in depressed patients who had partial response to clomipramine or imipramine: initial findings"
J Clin Psychiatry - 2000 Apr;61(4):285-9.https://pubmed.ncbi.nlm.nih.gov/10830150/
- Scott
Posted by undopaminergic on February 4, 2022, at 8:27:26
In reply to I can't believe I never thought of this combo., posted by SLS on February 3, 2022, at 9:48:46
> Hi, All.
>
> I can't believe my lack of imagination that this idea never occurred to me and that this article escaped me for 22 years.
>Well, it's not exactly an intuitive combination. Clomipramine (and imipramine to a lesser extent) already inhibits both serotonin and noradrenaline (norepinephrine) reuptake, which is the same thing that venlafaxine (supposedly) does, so wherein lies the mechanism of action behind the success of this combination?
-undopaminergic
Posted by jay2112 on February 8, 2022, at 15:59:16
In reply to I can't believe I never thought of this combo., posted by SLS on February 3, 2022, at 9:48:46
> Hi, All.
>
> I can't believe my lack of imagination that this idea never occurred to me and that this article escaped me for 22 years.
>
>
>
> "Combined treatment with venlafaxine and tricyclic antidepressants in depressed patients who had partial response to clomipramine or imipramine: initial findings"
>
>
> J Clin Psychiatry - 2000 Apr;61(4):285-9.
>
> https://pubmed.ncbi.nlm.nih.gov/10830150/
>
>
> - ScottOh, I've tried that combo hundred's of times. Sorry, but for moi, bleah! Effexor with high dose Lyrica, with it's powerful pro-GABBA effects, are what I think Nardil folks probably similarly experience, as Nardil has a unique pro-GABBA effect too.
Just IMHO, etc.
Jay
Posted by SLS on February 27, 2022, at 14:13:45
In reply to Re: I can't believe I never thought of this combo. » SLS, posted by jay2112 on February 8, 2022, at 15:59:16
> > Hi, All.
> >
> > I can't believe my lack of imagination that this idea never occurred to me and that this article escaped me for 22 years.
> >
> >
> >
> > "Combined treatment with venlafaxine and tricyclic antidepressants in depressed patients who had partial response to clomipramine or imipramine: initial findings"
> >
> >
> > J Clin Psychiatry - 2000 Apr;61(4):285-9.
> >
> > https://pubmed.ncbi.nlm.nih.gov/10830150/
> >
> >
> > - Scott
>
> Oh, I've tried that combo hundred's of times. Sorry, but for moi, bleah! Effexor with high dose Lyrica, with it's powerful pro-GABBA effects, are what I think Nardil folks probably similarly experience, as Nardil has a unique pro-GABBA effect too.
>
> Just IMHO, etc.
This is one combination that I never tried. I don't know why it never occurred to me.This study of 11 cases concluded that TCA + Effexor was better than TCA alone. I don't think the authors tried to make a case that this particular combination is better than any other.
- Scott
Posted by SLS on February 27, 2022, at 14:37:09
In reply to Re: I can't believe I never thought of this combo. » SLS, posted by undopaminergic on February 4, 2022, at 8:27:26
> > Hi, All.
> >
> > I can't believe my lack of imagination that this idea never occurred to me and that this article escaped me for 22 years.
> >
>
> Well, it's not exactly an intuitive combination. Clomipramine (and imipramine to a lesser extent) already inhibits both serotonin and noradrenaline (norepinephrine) reuptake, which is the same thing that venlafaxine (supposedly) does, so wherein lies the mechanism of action behind the success of this combination?Sometimes, clinical investigators are smart enough not to be too smart. Empirical data doesn't need to be explained using guesswork in order for it to be useful. If it works, it works. That's all this study attempted to determine.
The results of the clinical trials of phenelzine (Nardil) in the 1960s were no less valid than any recent ones, despite the early investigator's not knowing anything about GABA.
- Scott
This is the end of the thread.
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