Posted by SLS on February 27, 2022, at 14:37:09
In reply to Re: I can't believe I never thought of this combo. » SLS, posted by undopaminergic on February 4, 2022, at 8:27:26
> > Hi, All.
> >
> > I can't believe my lack of imagination that this idea never occurred to me and that this article escaped me for 22 years.
> >
>
> Well, it's not exactly an intuitive combination. Clomipramine (and imipramine to a lesser extent) already inhibits both serotonin and noradrenaline (norepinephrine) reuptake, which is the same thing that venlafaxine (supposedly) does, so wherein lies the mechanism of action behind the success of this combination?Sometimes, clinical investigators are smart enough not to be too smart. Empirical data doesn't need to be explained using guesswork in order for it to be useful. If it works, it works. That's all this study attempted to determine.
The results of the clinical trials of phenelzine (Nardil) in the 1960s were no less valid than any recent ones, despite the early investigator's not knowing anything about GABA.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1118460
URL: http://www.dr-bob.org/babble/20220128/msgs/1118775.html