Psycho-Babble Medication Thread 1091550

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sketchy and shakey on effexor

Posted by porkpiehat on August 26, 2016, at 12:10:13

It's that feeling like you want to roll up in a ball and sleep but your brain wants to do flips inside your skull while your body compulsively rocks back and forth. It's been almost 2 weeks and there were minor issues with irritability and flatness but not like this.

This is just 37.5. But I'm taking 150mg lamictal also, which tends to amplify or "toxify" whatever other AD I take. I took klonopin for sleep last night wondering if that is interfering and giving a withdrawl effect?

Definitely feels more like serotonin edgy than a NE edgy I get from wellburtin or ritalin.

Not sure if these are the real "effects" kicking in and I'm not agreeing with it.

 

Re: sketchy and shakey on effexor

Posted by linkadge on August 26, 2016, at 15:08:43

In reply to sketchy and shakey on effexor, posted by porkpiehat on August 26, 2016, at 12:10:13

Sometimes I count out the individual 'spheroids' inside the capsule in order to customize a dose.

Linkadge

 

Re: sketchy and shakey on effexor » linkadge

Posted by porkpiehat on August 26, 2016, at 15:52:41

In reply to Re: sketchy and shakey on effexor, posted by linkadge on August 26, 2016, at 15:08:43

> Sometimes I count out the individual 'spheroids' inside the capsule in order to customize a dose.
>
> Linkadge

haha I just call them "beads."
The awful swirmy racing feeling disappeared at 3:30. I tend to feel better in the afternoons, so I'm not sure if that's the effexor settling out, lamictal settling out, or the 10mg propranolol I took hoping for sanity.

If this morning is what Effexor is supposed to feel like, I'm done!

 

Re: sketchy and shakey on effexor

Posted by rjlockhart37 on August 26, 2016, at 20:39:14

In reply to sketchy and shakey on effexor, posted by porkpiehat on August 26, 2016, at 12:10:13

effexor.....is very stimulating, in some people, and it could sometimes make irrtibility come ... but still try to stay on it, talk with your doctor about the dose because it is a good antidepressant but if these effects are preventing you from wellbeing, later on i guess switch

37.5 is the low dose of effexor, i think the maximmum dose they could go is 300mg (2 150mg XR capusles)

 

Re: sketchy and shakey on effexor

Posted by linkadge on August 27, 2016, at 8:04:56

In reply to Re: sketchy and shakey on effexor » linkadge, posted by porkpiehat on August 26, 2016, at 15:52:41

Start up on Effexor can be a bit stimulating. This will level out to some extent.

I agree with you that mood stabilizers tend to intensify everything (you'd think they'd do the opposite but they don't - at least not for me).

I take lithium and Effexor (or am supposed to be taking them).

Linkadge

 

Re: sketchy and shakey on effexor

Posted by porkpiehat on August 27, 2016, at 11:36:37

In reply to Re: sketchy and shakey on effexor, posted by linkadge on August 27, 2016, at 8:04:56

I feel sketchy in the morning before taking the effexor. sketchy and racy in a different way after, and I'm finding myself a little better after a beta blocker, which makes no sense, moreso than klonopin.

I don't want to make things worse but maybe I should increase before giving up. I also don't want to take something that needs klonopin and beta blocker just to be endurable.

 

Re: sketchy and shakey on effexor » linkadge

Posted by porkpiehat on August 27, 2016, at 13:47:22

In reply to Re: sketchy and shakey on effexor, posted by linkadge on August 27, 2016, at 8:04:56

What dose effexor? Did you feel terrible waking up in the mornings at first. you are lucky to be on a relatively simple regimen...did you try other mood stabilizer/anti-seizure meds?

> Start up on Effexor can be a bit stimulating. This will level out to some extent.
>
> I agree with you that mood stabilizers tend to intensify everything (you'd think they'd do the opposite but they don't - at least not for me).
>
> I take lithium and Effexor (or am supposed to be taking them).
>
> Linkadge

 

Re: sketchy and shakey on effexor

Posted by linkadge on August 27, 2016, at 17:51:18

In reply to Re: sketchy and shakey on effexor » linkadge, posted by porkpiehat on August 27, 2016, at 13:47:22

I have tried everything. At the moment, I am doing better on nothing.

I was on (up to) 75mg of Effexor. 37.5 worked better for me with fewer side effects. I would say it took me about 1-2 weeks to adjust.

I can't recall which time(s) of the day I felt better or worse, mainly that it produced a fairly strong stimulant like feeling.

If you are finding it too strong, I would try to reduce the dose for the first week.

You can empty the contents into a bowel and remove the balls by pressing your finger on them (they'll stick). You can discard 30 or so in the first week. Add applesauce to the rest in the bowel and eat.

Linkadge

 

Re: sketchy and shakey on effexor

Posted by rjlockhart37 on August 27, 2016, at 21:09:02

In reply to Re: sketchy and shakey on effexor, posted by linkadge on August 27, 2016, at 17:51:18

i've read effexor is one the most effective antidepressants that is superior in some cases to SSRI's ... but i was reading effexor withdrawl is horrid.....it's because the nuerotransmitters that have been enhanced by effexor fade as it leaves the system

this is from wikipedia...
"During withdrawal from venlafaxine, the levels of both serotonin and norepinephrine decrease, rather than increase, and this would appear to rule out toxic (too high) levels of these neurotransmitters as a likely cause of the withdrawal symptoms. The withdrawal symptoms can be hypothesized to result from an overly rapid deprivation of neurotransmitter levels"

so i think your ok because you on a low dose, it's higher doses that achieve maximum antidepressant effect, but also at maximum doses is when the withdrawl becomes horrid....be careful and work with your doctor on doses, or another antidepressant

 

Re: sketchy and shakey on effexor

Posted by porkpiehat on August 28, 2016, at 12:16:02

In reply to Re: sketchy and shakey on effexor, posted by rjlockhart37 on August 27, 2016, at 21:09:02

The effect I'm getting is neither helpful with depression nor social anxiety nor concentration. Although yesterday I took 5mgs ritalin to cut through some of these issues and I feel like a found a key piece of the puzzle.

I was worried the NE effects of effexor would make ritalin intolerable but I don't think they are significant at this dose. In fact without the effexor (or an ssri) ritalin would normally put me through the roof.

I think I'm going to edge up half a pill on the effexor to see if the badness is ramp up or the "therapeutic" effects of the drug and make my decision before getting in too deep.

I've heard nasty tales of comedown. I will say I probably feel worst when I wake up in the morning, which is right before dosing.

Still trying to figure out the role of lamictal.

 

Re: sketchy and shakey on effexor

Posted by rjlockhart37 on August 28, 2016, at 20:17:56

In reply to Re: sketchy and shakey on effexor, posted by porkpiehat on August 28, 2016, at 12:16:02

this is what i found about effexor......

0-75mg it mainly work on serotonin

moderate doses begin to work on NE

higher doses (300mg) work some on dopamine

effexor has a high response rate on depression especially in higher doses, because it works on 3 neurotransmitters at higher doses, just be careful because some people it's too stimulating and can cause irritability

 

Re: sketchy and shakey on effexor

Posted by Lamdage22 on August 29, 2016, at 15:04:58

In reply to sketchy and shakey on effexor, posted by porkpiehat on August 26, 2016, at 12:10:13

> It's that feeling like you want to roll up in a ball and sleep but your brain wants to do flips inside your skull while your body compulsively rocks back and forth. It's been almost 2 weeks and there were minor issues with irritability and flatness but not like this.
>
> This is just 37.5. But I'm taking 150mg lamictal also, which tends to amplify or "toxify" whatever other AD I take. I took klonopin for sleep last night wondering if that is interfering and giving a withdrawl effect?
>
> Definitely feels more like serotonin edgy than a NE edgy I get from wellburtin or ritalin.
>
> Not sure if these are the real "effects" kicking in and I'm not agreeing with it.

I think that Effexor does not help anxiety at all. I also take 37.5mg

 

Re: sketchy and shakey on effexor

Posted by linkadge on August 29, 2016, at 19:37:55

In reply to Re: sketchy and shakey on effexor, posted by Lamdage22 on August 29, 2016, at 15:04:58

With Effexor xr, I don't notice too much daily variation - at least after it has had a few days to build up in your system.

It shouldn't feel like an upper (i.e. crashes). The XR version should release some med later in the day, and the metabolites from this should stay in your system more than 24 hours.

Linkadge

 

Re: sketchy and shakey on effexor

Posted by porkpiehat on September 1, 2016, at 12:21:29

In reply to Re: sketchy and shakey on effexor, posted by linkadge on August 29, 2016, at 19:37:55

Ok I'm past two weeks. I was having what I'm guessing was weird "ramping up" sketchy feelings that comes with introducing an ssri. Monday I actually felt a "happy" lift like I associate with an SSRI but it has been descending into a zoney tiredness.

Yesterday I almost vomitted on a client and felt weak and irritable until I remembered I forgot to take my morning klonopin, which helped for a few hours.

This morning I felt fine until taking the effexor and then I felt nervous worried, and very uncomfortable, even with klonopin and propranolol.

So my question is, if I'm taking an alpha and beta blocker to offset nightmares and trauma, should I be taking an NE re-uptake inhibitor? Each time I've take provigil or yohimbine I feel feverish, trippy, and scared. Is this not a trauma arousal issue maybe caused from NE?

http://www.ncbi.nlm.nih.gov/pubmed/10560025

I know a lot of people with PTSD have success on Effexor so I don't want to make simple conclusions. I raised my morning lamictal dose and it feels like it helped. I was hoping to lose the lamictal altogether.

Thoughts?

 

Re: sketchy and shakey on effexor

Posted by rjlockhart37 on September 2, 2016, at 0:43:49

In reply to Re: sketchy and shakey on effexor, posted by porkpiehat on September 1, 2016, at 12:21:29

if your feeling nervous or agitated on effexor....it is a NE reptake inhibitor but it mainly targets serotonin, it's the higher doses where it targets more NE and slightly dopamine (300mg)

you could venture off it, and maybe start something like remeron.....effexor is a very good antidepressant, but some people just like wellbutrin it can cause agitation

maybe ask and work with your doctor about another antidepressant....

stay away from NE from now on.....maybe target serotonin

 

Re: sketchy and shakey on effexor

Posted by linkadge on September 4, 2016, at 7:41:50

In reply to Re: sketchy and shakey on effexor, posted by porkpiehat on September 1, 2016, at 12:21:29

You have to go by your reaction.

In theory, Effexor shouldn't cause norepinephrine related side effects at low doses, but it does seem to.

I personally use (much) less than 37.5mg and still get a benefit.

I get co-venlafaxine which contains 3 pucks (no spheroids). Each puck would be 12.5mg. Even 12.5mg has a positive effect on me.

If you cannot tolerate 37.5mg after 2-3 weeks then you may wish to reduce the dose (or stop altogether) as this is a decent trial.

If you notice that side effects in week 2 were less than week 1, then you could give it more time.

Linkadge

 

Re: sketchy and shakey on effexor

Posted by Porkpiehat on September 6, 2016, at 6:11:28

In reply to Re: sketchy and shakey on effexor, posted by linkadge on September 4, 2016, at 7:41:50

The sketchy feeling is largely gone. I feel less pressured in personal interactions but on the flip side I'm largely uninterested in reaching out to or interacting with people. I also don't have much for drive for activities other than homework or reading.

I just went on a fishing trip and spent most of my time alone reading organic chemistry. I've been taking Ritalin for the last couple of days which at least had made me task oriented but I'm veery irritated if anyone interrupts me.

 

Re: sketchy and shakey on effexor » Porkpiehat

Posted by linkadge on September 6, 2016, at 7:40:50

In reply to Re: sketchy and shakey on effexor, posted by Porkpiehat on September 6, 2016, at 6:11:28

Effexor was good for my anxiety (after adjusting to the dose), however it did tend to make me a bit more antisocial.

It's hard to explain, but on Effexor I did prefer to be alone. Sometimes this was beneficial, as I was able to accomplish more without the distraction of other people.

Linkadge

 

Re: sketchy and shakey on effexor » linkadge

Posted by Porkpiehat on September 6, 2016, at 13:37:59

In reply to Re: sketchy and shakey on effexor » Porkpiehat, posted by linkadge on September 6, 2016, at 7:40:50

Yeah this will be great for studying but what about dates and vacations? Any thoughts on countering? On celexa Ritalin would give all kinds of energy. Now I just want to suck into hobbies. Maybe adderal or Wellbutrin?

 

Re: sketchy and shakey on effexor » linkadge

Posted by porkpiehat on September 6, 2016, at 16:40:14

In reply to Re: sketchy and shakey on effexor » Porkpiehat, posted by linkadge on September 6, 2016, at 7:40:50

> Effexor was good for my anxiety (after adjusting to the dose), however it did tend to make me a bit more antisocial.
>
> It's hard to explain, but on Effexor I did prefer to be alone. Sometimes this was beneficial, as I was able to accomplish more without the distraction of other people.
>
> Linkadge

What dose?

 

Re: sketchy and shakey on effexor » porkpiehat

Posted by linkadge on September 6, 2016, at 19:14:54

In reply to Re: sketchy and shakey on effexor » linkadge, posted by porkpiehat on September 6, 2016, at 16:40:14

75mg.

Antisocial might not be the best word. I did ok in social situations, its just that (increasingly) I preferred being alone.

Linkadge

 

Re: sketchy and shakey on effexor » linkadge

Posted by porkpiehat on September 20, 2016, at 15:33:21

In reply to Re: sketchy and shakey on effexor » porkpiehat, posted by linkadge on September 6, 2016, at 19:14:54

That's really spot on! I flew to visit friends in SF and I was so uninterested in them. It actually got uncomfortable because I had no rapport whatsoever.

I addeded 10mgs of Vyvanse and kinda "felt like my old self again."
Engaged and interested, not falling asleep in the afternoon, and my brain was constantly distracted by bad, bad thoughts.

Two weeks later I'm just tired all the time and I think it has f*ck*d with my sleep. Might have been manic this weekend?

anywho, if the Vyvanse doesn't work than I don't think the Effexor is going to work. Mehrd.


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