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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Hello321 on August 30, 2015, at 12:39:42
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013794/
Conclusions and implications: Rat somatodendritic 5-HT1A receptors controlling hippocampal 5-HT release were rapidly desensitized by chronic activation with a high-efficacy 5-HT1A agonist, but not by chronic activation with a partial agonist. Thus, rapid 5-HT1A autoreceptor desensitization by high-efficacy agonists may accelerate the onset of the therapeutic effects of antidepressants.
Posted by SLS on August 30, 2015, at 12:46:28
In reply to Benefit of 5ht1a agonists (like Flibanserin/Addyi), posted by Hello321 on August 30, 2015, at 12:39:42
Pindolol?
Posted by SLS on August 30, 2015, at 12:50:31
In reply to Re: Benefit of 5ht1a agonists (like Flibanserin/Addyi) » Hello321, posted by SLS on August 30, 2015, at 12:46:28
> Pindolol?
Oops.
Pindolol is an antagonist (somatodendritic, I believe). However, it was once investigated for its purported ability to accelerate the therapeutic effects of SSRIs.
:-(
- Scott
Posted by Hello321 on August 30, 2015, at 13:10:02
In reply to Re: Benefit of 5ht1a agonists - Oops » SLS, posted by SLS on August 30, 2015, at 12:50:31
http://www.ncbi.nlm.nih.gov/pubmed/9661257
Well, heres another study saying Flibanserin acts as a full agonist for 5ht1a receptors in certain areas of the brain and just a partial agonist at others, if i understand correctly. Then it says "Therefore, flibanserin presented a marked selectivity for postsynaptic 5-HT1A receptors when applied locally, but not when administered intravenously. It remains to be determined if flibanserin preferentially activates postsynaptic 5-HT1A receptors upon sustained systemic administration."
Uhh, what does that mean exactly? One has to take it a certain way for it to work at postsynapic receptors? Im guessing when taken by mouth, at least chronically, it does indeed agonoze the postsynaptic receptors.
This is the end of the thread.
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