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Benefit of 5ht1a agonists (like Flibanserin/Addyi)

Posted by Hello321 on August 30, 2015, at 12:39:42

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013794/

Conclusions and implications: Rat somatodendritic 5-HT1A receptors controlling hippocampal 5-HT release were rapidly desensitized by chronic activation with a high-efficacy 5-HT1A agonist, but not by chronic activation with a partial agonist. Thus, rapid 5-HT1A autoreceptor desensitization by high-efficacy agonists may accelerate the onset of the therapeutic effects of antidepressants.


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poster:Hello321 thread:1081915
URL: http://www.dr-bob.org/babble/20150806/msgs/1081915.html