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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by JohnV on March 27, 2003, at 20:06:59
Hello everyone, has anybody been on moclobemide (Manerix) for a long period of time. I tried it before alone and it seemed to make my anxiety worse. I am now, with my pshysicians approval, going to take it with a good benzodiazepine and my codiene pain medication. My physician said besides Demerol (opiod), he has seen no problems with use with codiene. I take codiene for arthritic and back pain problems and it is not a large amount.So are there any other Moclobemide (Manerix) takers to help with ideas, or just support? I was on Effexor Xxtended Release (XR) for many years, and at high doses (450mg's), but it not only ruined my sex drive and made me fat and lethargic but didn't barely touch the depression and made anxiety often worse. After 12 years the only other option is a regular MAOI, but not only could I not ever stick to the diet I often have to take other meds that are contraindicated. It is an option of last resort I know (taking a regular MAOI), but this current combo with moclobemide (an Reversible MAOI) came close to working well before and now with the addition of other medications may bring me to the top. Plus, it has also gone generic, and is cheaper which helps as I am unemployed.
I would do anything in the world to lose that """mind freeze" Effexor caused, and I cannot tolerate any other SSRI and only nortripyline is the other med that I can handle. So many, too many, meds just focus on serotonin, and there isn't much around (easily prescribed) for meds that affect particular pathways in the dopamine, norepinephrine, and opioid pathways. There are individual meds, but none that act together in a unique way. (like, my doctor talks about a med can upregulate, downregulate, and act with very specific precision on sub-receptors like Dopamine 1-2-3-4 and serotonin 5H2, a, 5H3, 5H4, etc.)
So I would really like any comments please. If I can help anyone too, please I will try. Thank you so much. John
Posted by phoenician on March 19, 2013, at 9:09:11
In reply to Moclobemide. Anyone on it long term?, posted by JohnV on March 27, 2003, at 20:06:59
I've been taking moclobemide for several months, originally prescribed for anxiety and depression. When I started taking it, I noticed the positive effects immediately - improved mood, alertness, and motivation, as well as an increased sex drive - within a couple of hours of taking my first dose. After a couple weeks I also started to feel a lot calmer, but not sedated (though I do sleep better now on the whole).
The effects are no longer as noticeable, but I've also reduced the dose to about half what I was originally prescribed (down to 100 mg per day - I cut the tablet in half and take half in the morning and half in the evening), as I feel this is enough to get the support I need. I don't want to feel "high", just well.
I haven't really noticed any side effects. If I take the pill too close to bed time, it can keep me awake for a while. Sometimes I feel that I'm more absent minded than I used to be, but it's difficult to be objective about that - the situation that was causing me to be anxious/stressed is still present in my life (for now) and is just as likely to be the cause of my being distracted.
On the whole, I'd say it's been a success. Just for reference, I'm a middle aged male in very good physical health, and I drink alcohol moderately. Moclobemide is the second anti-depressent I tried. The first was cipramil, but I didn't like the way it made me feel so I never got past the first dose.
Hope my experience helps.
Posted by ChicagoKat on March 19, 2013, at 13:26:25
In reply to Re: Moclobemide. Anyone on it long term?, posted by phoenician on March 19, 2013, at 9:09:11
It sucks that moclobemide is not available in the US. I would love to try it.
Posted by phoenician on March 20, 2013, at 6:24:57
In reply to Re: Moclobemide. Anyone on it long term?, posted by ChicagoKat on March 19, 2013, at 13:26:25
I think the rule of thumb is to keep trying meds until you find one you like and then stick to it as long as it works for you.
I'm not entirely convinced that the pharmacists, chemists, doctors, etc, really know how these drugs work or why they effect people so differently. What works great for me might do nothing for you, or worse, make you feel bad.
Moclobemide belongs to a class of drugs called Reversible inhibitor of monoamine oxidase A (RIMA). There are other drugs on the market in the same family which you could ask your doctor about. Here's a short list:
Metralindole
Minaprine
Pirlindole
Toloxatone
Posted by ChicagoKat on March 20, 2013, at 15:00:48
In reply to Re: Moclobemide. Anyone on it long term?, posted by phoenician on March 20, 2013, at 6:24:57
thanks for the info=
i am actually one of those pharmacists who has no idea how drugs really work, or at least i used to be in a previous life. :)case in point: i never knew how bad benzo withdrawal could be during my 18yr hospital-based career. i know now, i am going through hell!!
thanks again,
Kat
This is the end of the thread.
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