![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 50 to 74 of 96. Go back in thread:
Posted by Solstice on February 25, 2012, at 2:15:10
In reply to Re: Papillon's response to Solstice + SLS, posted by papillon2 on February 25, 2012, at 0:19:18
>
> So was I. Dihydrogen monoxide = another way to write hydrogen dioxide = water. The site is a spoof. ;-)ha! so I guess my relative weakness in chemistry is showing... :-)
Sol
Posted by ed_uk2010 on February 25, 2012, at 3:01:08
In reply to Re: Papillon's response to Solstice + SLS » papillon2, posted by Solstice on February 25, 2012, at 2:15:10
I've been thinking of cutting out all carbs, fat, protein and vitamins from my diet. All those hydrogen atoms are worrying, I might explode!
Those vitamin Bs are especially scary. The benzene ring in folic acid could cause liver, kidney, heart, lung, bone marrow and brain failure :O
Posted by SLS on February 25, 2012, at 6:12:20
In reply to Lou's request-pheytal, posted by Lou Pilder on February 24, 2012, at 20:46:52
> Friends,
> Here is a link to a site that lists the effects of Saphris to the one taking he drug.I would like for interested readers to look a this in relation to adverse effects listed.
> Lou
> http://www.drugs.com/pro/saphris.htmlYup. Neuroleptics can be nasty drugs. They often give people back their lives, though. The neuroleptic I take causes in me weight gain and elevated triglycerides. These things are not very healthy, but are side effects I am more than willing to accept for the dramatic improvement in my quality of life the drug gives me. I do not suffer any of the other scary side effects listed.
When attempting to accurately evaluate the reported side effect profile of a drug, it is necessary to look at the frequency of occurrence of these effects by comparing the drug to placebo or the rate seen in the general population. The webpage you cite includes percentages of emergent side effects.
Rxlist uses charts:
http://www.rxlist.com/saphris-drug/side-effects-interactions.htm
Regarding the black box warning, people with Alzheimers Dementia seem to die at a higher rate when they take neuroleptic drugs related to Saphris, even though Saphris itself has not been reported to do so on Medline/Pubmed. Risperdal, haloperidol, chlorpromazine and trifluoperazine are the drugs that have received the most attention recently. These are relative old and high potency D2 agonist drugs. Not all antipsychotic medication carries the same risk of death in elderly populations. So, the warning is given for all members of the neuroleptic class of drugs out of prudence.
Neuroleptic antipsychotic drugs, when used in Alzheimers Dementia, doubles the risk of death from all causes after one year. Scientists don't know why yet. This is very sad. Still, in many cases, the benefits are deemed to outweigh the risks. Unfortunately, behavioral dyscontrol and psychosis are often present in Alzheimers patients.
When I blew out the candles for my fifth birthday, I didn't make a wish that I take neuroleptic antipsychotic drugs when I grew up.
- Scott
Posted by ed_uk2010 on February 25, 2012, at 9:36:17
In reply to Re: Lou's request-pheytal » Lou Pilder, posted by SLS on February 25, 2012, at 6:12:20
>The neuroleptic I take causes in me weight gain and elevated triglycerides. These things are not very healthy, but are side effects I am more than willing to accept for the dramatic improvement in my quality of life the drug gives me.
Hi Scott,
Do you take lipid-lowering medication?
Posted by Lou Pilder on February 25, 2012, at 9:41:12
In reply to Lou's request-pheytal, posted by Lou Pilder on February 24, 2012, at 20:46:52
Friends,
If you are considering posting in this thread, I am requesting that you view the following video.
lou
To see this video;
A. Bring up Google
B. Type in:
[youtube, Antipsychotics or Neuroleptics, Dr Gary Kohls]
usually first
Posted by SLS on February 25, 2012, at 10:02:05
In reply to Triglycerides » SLS, posted by ed_uk2010 on February 25, 2012, at 9:36:17
> >The neuroleptic I take causes in me weight gain and elevated triglycerides. These things are not very healthy, but are side effects I am more than willing to accept for the dramatic improvement in my quality of life the drug gives me.
>
> Hi Scott,
>
> Do you take lipid-lowering medication?Not yet. I have an appointment to see my GP on Monday. I am afraid to take Lovaza. My brain does not like fish oil. It makes my depression worse. I am thinking about taking OmegaBrite. It is fish oil with pure EPA and no DHA. I'm guessing that it is the DHA component of Carlson's fish oil that is responsible for the exacerbation of depression. Pure DHA can make one more depressed.
http://www.ncbi.nlm.nih.gov/pubmed/20439549
Any suggestions?
Thanks.
- Scott
Posted by Phillipa on February 25, 2012, at 10:14:23
In reply to Re: Triglycerides » ed_uk2010, posted by SLS on February 25, 2012, at 10:02:05
Nordic Naturals caused this new aggitation in me. I guess all are not meant to take it. I discontinued it and now it's gone so the fish oil. The compounding RX said it takes a month to develop the enzyme to benefit from it? Never heard this but it was about a month and aggitation. Guess it's not for all. Phillipa
Posted by ed_uk2010 on February 25, 2012, at 11:07:49
In reply to Re: Triglycerides » ed_uk2010, posted by SLS on February 25, 2012, at 10:02:05
>Any suggestions?
Fibrate drugs are the most effective triglyceride lowering agents, but they don't have a great record in terms of preventing cardiovascular events. Statins have a lot more evidence to support their cardiac benefits, even though they aren't as reliable at lowering triglycerides. Statins are very effective at reducing cholesterol, but you don't have to have high cholesterol to benefit. If your doctor considers you to be at risk of cardiovascular disease, you could consider atorvastatin initially. Statins have been reported to cause psychiatric adverse effects in some patients. If that was to occur, a fibrate might be appropriate.
Have you tried orlistat (Xenical) as an aid to weight loss?
Posted by Elanor Roosevelt on February 25, 2012, at 20:24:38
In reply to Lou's request-lhvngdhed, posted by Lou Pilder on February 25, 2012, at 9:41:12
Friends, If you are going to continue to follow this thread I strongly suggest you take a moment to view this important video:
http://www.youtube.com/watch?v=mjatRkpSa5U&feature=related
Thank you for your cooperation
Posted by Lou Pilder on February 27, 2012, at 20:28:57
In reply to Lou's request-pheytal, posted by Lou Pilder on February 24, 2012, at 20:46:52
> > > > > > I invite any feedback from anyone who has any info about Saphris!
> > > > > >
> > > > > > Solstice
> > > >
> > > > > Solstice,
> > > > You wrote,[...I invite any feedback from anyone...].
> > > > The subject here is the use of the drug {Saphris}.
> > > > The drug has a constituant in it that was used as a gas in riot control in the 50's.
> > > > Lou
> > > >
> > > > Lou Pilder.
> > > >
> > > > You posted this statement along another thread. The original poster had asked for info about Saphris. It is my contention that you failed to do this. I don't see any information. I see words. I challenge you to prove your words. If you cannot, you might want to apologize to the person to whom you directed it for posting misinformation.
> > > >
> > > > There is so much more to this.
> > > >
> > > >
> > > > - Scott
> > > >
> > >
> > > Scott,
> > > You wrote that you think that I failed to give information concerning Saphris. The information that I gave was that Saphris has a constituant in it that was used as a gas in riot control in the 50's. You have asked me for more information concerning the words seen in that post in another thread.
> > > In order to have more information concerning the gas used in riot control in the 50's, I would like to start with Benzene.
> > > Benzene usually comes from coal tar or petroleum. You can hydroxylate benzene and get {phenol}. From phenol you can get {phenyl}.
> > > Now benzene can cause leukemia and other cancers and break chromosomes. Benzene is used in a lot of manufacturing of products including rubber, pesticides, drugs and explosives.
> > > Benzene is cancerous when breathed in the air. Benzene can also be injested and cause cancer and death. Benzene rings can be chemically coupled.
> > > Benzene was discoverd hundreds of years ago. The toxic properties and the carcinogenic properties of benzene were not proven until the early 1900's
> > > I intend to finish this unless the rule of 3 applies.
> > > Lou
> >
> > Friends,
> > What is Saphris? Where did it come from? What can it do to the one taking the drug? And other aspects.
> > Now after the riot control gas that was made in the 50's, there came a drug called Clozeril/Clozapine.
> > This drug killed many by attacking the blood to cause what is known as {agranulocytosis} which can be fatal. It also can cause diabetes, and a fatal cardic condition. There is a withdrawal from cessation which means that it could be considerd to be addictive depending on how you want to define addiction/withdrawal.
> > At any rate, the drug has many possible ways to kill the one taking it. This drug came out in the 70's.
> > Now we have {benzene} and {clozeril}. There are constituants in clozeril that are used in a gas for riot control devised in the 50's but used today in many countries.
> > Now I intend to contiue to go step by step to show what Saphris is constituted of , chemically that is. unless the rule of 3 applies.
> > Lou
>
> Friends,
> Here is a link to a site that lists the effects of Saphris to the one taking he drug.I would like for interested readers to look a this in relation to adverse effects listed.
> Lou
> http://www.drugs.com/pro/saphris.htmlFriends,
Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}. Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
This drug has been taken off the market because of how it could cause heart disease and death. It also can cause agranulocytosis, which is a blood disease that can be fatal.
Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine. So if you read the Saphris PI there could be the disclosure of possible agranulosis. In the clinical trials, there were many deaths. Now I have not talked about the phenethylamines yet, but I meantioned them in the thread concerning Effexor. I was posted by Mr. Hsiung during that thread a prohibition that precluded me from posting a lot of information that I think, if allowed to be seen here, could save lives or prevent a life-ruining condition or addiction. I could have that same preclusion here, that might also prevent me from posting what could save lives.
So I have posted about the riot control gas, and clozaril and now Fenfluramine.
So we have seen a little about this drug called Saphhris and I intend to complete this exposition, unless the rule of three applies.
Lou
Posted by Lou Pilder on February 27, 2012, at 20:54:23
In reply to Lou's request-fenfluramine, posted by Lou Pilder on February 27, 2012, at 20:28:57
> > > > > > > I invite any feedback from anyone who has any info about Saphris!
> > > > > > >
> > > > > > > Solstice
> > > > >
> > > > > > Solstice,
> > > > > You wrote,[...I invite any feedback from anyone...].
> > > > > The subject here is the use of the drug {Saphris}.
> > > > > The drug has a constituant in it that was used as a gas in riot control in the 50's.
> > > > > Lou
> > > > >
> > > > > Lou Pilder.
> > > > >
> > > > > You posted this statement along another thread. The original poster had asked for info about Saphris. It is my contention that you failed to do this. I don't see any information. I see words. I challenge you to prove your words. If you cannot, you might want to apologize to the person to whom you directed it for posting misinformation.
> > > > >
> > > > > There is so much more to this.
> > > > >
> > > > >
> > > > > - Scott
> > > > >
> > > >
> > > > Scott,
> > > > You wrote that you think that I failed to give information concerning Saphris. The information that I gave was that Saphris has a constituant in it that was used as a gas in riot control in the 50's. You have asked me for more information concerning the words seen in that post in another thread.
> > > > In order to have more information concerning the gas used in riot control in the 50's, I would like to start with Benzene.
> > > > Benzene usually comes from coal tar or petroleum. You can hydroxylate benzene and get {phenol}. From phenol you can get {phenyl}.
> > > > Now benzene can cause leukemia and other cancers and break chromosomes. Benzene is used in a lot of manufacturing of products including rubber, pesticides, drugs and explosives.
> > > > Benzene is cancerous when breathed in the air. Benzene can also be injested and cause cancer and death. Benzene rings can be chemically coupled.
> > > > Benzene was discoverd hundreds of years ago. The toxic properties and the carcinogenic properties of benzene were not proven until the early 1900's
> > > > I intend to finish this unless the rule of 3 applies.
> > > > Lou
> > >
> > > Friends,
> > > What is Saphris? Where did it come from? What can it do to the one taking the drug? And other aspects.
> > > Now after the riot control gas that was made in the 50's, there came a drug called Clozeril/Clozapine.
> > > This drug killed many by attacking the blood to cause what is known as {agranulocytosis} which can be fatal. It also can cause diabetes, and a fatal cardic condition. There is a withdrawal from cessation which means that it could be considerd to be addictive depending on how you want to define addiction/withdrawal.
> > > At any rate, the drug has many possible ways to kill the one taking it. This drug came out in the 70's.
> > > Now we have {benzene} and {clozeril}. There are constituants in clozeril that are used in a gas for riot control devised in the 50's but used today in many countries.
> > > Now I intend to contiue to go step by step to show what Saphris is constituted of , chemically that is. unless the rule of 3 applies.
> > > Lou
> >
> > Friends,
> > Here is a link to a site that lists the effects of Saphris to the one taking he drug.I would like for interested readers to look a this in relation to adverse effects listed.
> > Lou
> > http://www.drugs.com/pro/saphris.html
>
> Friends,
> Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}. Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> This drug has been taken off the market because of how it could cause heart disease and death. It also can cause agranulocytosis, which is a blood disease that can be fatal.
> Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine. So if you read the Saphris PI there could be the disclosure of possible agranulosis. In the clinical trials, there were many deaths. Now I have not talked about the phenethylamines yet, but I meantioned them in the thread concerning Effexor. I was posted by Mr. Hsiung during that thread a prohibition that precluded me from posting a lot of information that I think, if allowed to be seen here, could save lives or prevent a life-ruining condition or addiction. I could have that same preclusion here, that might also prevent me from posting what could save lives.
> So I have posted about the riot control gas, and clozaril and now Fenfluramine.
> So we have seen a little about this drug called Saphhris and I intend to complete this exposition, unless the rule of three applies.
> LouNow the effects that saphris has on the blood is common to other drugs that have the same or similar chemical make-up. A lot of those cause agranulocytosi , such as Clozaril, and some cause a similar life-threatening condition called neutropenia, which is concerning the neutrophils in the blood. What is omprtant to the taker of these class of drugs is that {fever} can happem that is indicating this potential fatal happening of neutropenia. So a fever could warn of this condtion that could cause death.
Lou
Posted by Phillipa on February 27, 2012, at 21:16:08
In reply to Lou's request-neutropenia, posted by Lou Pilder on February 27, 2012, at 20:54:23
True about Clozaril that I do know. Thanks for keeping the Shoppe open. Phillipa
Posted by Solstice on February 27, 2012, at 21:41:55
In reply to Re: Lou's request-neutropenia » Lou Pilder, posted by Phillipa on February 27, 2012, at 21:16:08
> True about Clozaril that I do know. Thanks for keeping the Shoppe open. Phillipa
Yes, thank you for keeping the Shoppe open.Solstice
Posted by Lou Pilder on February 27, 2012, at 21:46:53
In reply to Re: Lou's request-neutropenia, posted by Solstice on February 27, 2012, at 21:41:55
> >
Phillipa and Solstice,
I need a night-watchman or night watch-woman. Could you take care of it?
LouTrue about Clozaril that I do know. Thanks for keeping the Shoppe open. Phillipa
>
>
> Yes, thank you for keeping the Shoppe open.
>
> Solstice
Posted by SLS on February 27, 2012, at 21:57:09
In reply to Lou's request-fenfluramine, posted by Lou Pilder on February 27, 2012, at 20:28:57
> Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
Okay.
> Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> This drug has been taken off the marketAlso, fenfluramine itself has been taken off of the market.
> because of how it could cause heart disease and death.
Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
Fenfluramine is a dangerous drug.
> Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
To the best of my knowledge, this is misinformation.
Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
> So if you read the Saphris PI there could be the disclosure of possible agranulosis.
To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
> In the clinical trials, there were many deaths.
To the best of my knowledge, this is misinformation.
Please provide citations for this statement.
Your use of the word "many" is an exagerration.
To the best of my knowledge the 3-post rule still applies. Life is good.
- Scott
Posted by SLS on February 27, 2012, at 22:03:40
In reply to Re: Lou's request-fenfluramine, posted by SLS on February 27, 2012, at 21:57:09
So that there be no confusion, please note that asenapine is the generic name for Saphris.
I wrote the following in my previous post:
> Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
- Scott
Posted by Lou Pilder on February 27, 2012, at 22:10:29
In reply to Re: Lou's request-fenfluramine, posted by SLS on February 27, 2012, at 21:57:09
> > Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
>
> Okay.
>
> > Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> > This drug has been taken off the market
>
> Also, fenfluramine itself has been taken off of the market.
>
> > because of how it could cause heart disease and death.
>
> Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
>
> Fenfluramine is a dangerous drug.
>
> > Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
>
> To the best of my knowledge, this is misinformation.
>
> Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
>
> > So if you read the Saphris PI there could be the disclosure of possible agranulosis.
>
> To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
>
> Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
>
> > In the clinical trials, there were many deaths.
>
> To the best of my knowledge, this is misinformation.
>
> Please provide citations for this statement.
>
> Your use of the word "many" is an exagerration.
>
> To the best of my knowledge the 3-post rule still applies. Life is good.
>
>
> - ScottScott,
https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.html
Posted by Lou Pilder on February 27, 2012, at 22:18:00
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29
> > > Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
> >
> > Okay.
> >
> > > Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> > > This drug has been taken off the market
> >
> > Also, fenfluramine itself has been taken off of the market.
> >
> > > because of how it could cause heart disease and death.
> >
> > Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
> >
> > Fenfluramine is a dangerous drug.
> >
> > > Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
> >
> > To the best of my knowledge, this is misinformation.
> >
> > Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
> >
> > > So if you read the Saphris PI there could be the disclosure of possible agranulosis.
> >
> > To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
> >
> > Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
> >
> > > In the clinical trials, there were many deaths.
> >
> > To the best of my knowledge, this is misinformation.
> >
> > Please provide citations for this statement.
> >
> > Your use of the word "many" is an exagerration.
> >
> > To the best of my knowledge the 3-post rule still applies. Life is good.
> >
> >
> > - Scott
>
> Scott,
> https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.htmlScott and friends,
Here is the FDA report regarding saphris. It is over 1000 pages so your system may not bring this up. It will take a long time...acrobat
Now I have highlights of the report that I will post later...
Lou
UCM173877
or
UCM123877
Posted by Solstice on February 27, 2012, at 22:26:49
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29
> Scott,
> https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.htmlInteresting... I used the "death" events filter on this site, and it came up with zero, which is far less than the "many" you reported.
Solstice
Posted by SLS on February 27, 2012, at 22:39:51
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29
Not good enough.
Try again.
Or not.
There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
Do you know the difference between misinformation and disinformation? Just curious.
Please feel free to ask me any questions that you would like to have answered along this thread.
- Scottt
Posted by Phillipa on February 27, 2012, at 22:52:19
In reply to Lou's request to Phillipa and Solstice, posted by Lou Pilder on February 27, 2012, at 21:46:53
Lou I'm sorry must decline watching Shoppe at night as I think we are almost on the same time zone. So we sleep at the same time within an hour or so. So sorry. Phillipa
Posted by Lou Pilder on February 27, 2012, at 22:54:00
In reply to Re: Scott's reply-agranulocytosis » Lou Pilder, posted by SLS on February 27, 2012, at 22:39:51
> Not good enough.
>
> Try again.
>
> Or not.
>
> There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
>
> Do you know the difference between misinformation and disinformation? Just curious.
>
> Please feel free to ask me any questions that you would like to have answered along this thread.
>
>
> - ScotttScott,
Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
Lou
http://circ.ahjournals.org/content/1022/23/2836.full
Posted by Lou Pilder on February 27, 2012, at 22:57:14
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:54:00
> > Not good enough.
> >
> > Try again.
> >
> > Or not.
> >
> > There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
> >
> > Do you know the difference between misinformation and disinformation? Just curious.
> >
> > Please feel free to ask me any questions that you would like to have answered along this thread.
> >
> >
> > - Scottt
>
> Scott,
> Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> Lou
> http://circ.ahjournals.org/content/1022/23/2836.full
corrected:
http://circ.ahjournals.org/content/102/23/2836.full
Posted by Lou Pilder on February 27, 2012, at 23:02:28
In reply to correction- Lou's reply-agranulocytosis, posted by Lou Pilder on February 27, 2012, at 22:57:14
> > > Not good enough.
> > >
> > > Try again.
> > >
> > > Or not.
> > >
> > > There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
> > >
> > > Do you know the difference between misinformation and disinformation? Just curious.
> > >
> > > Please feel free to ask me any questions that you would like to have answered along this thread.
> > >
> > >
> > > - Scottt
> >
> > Scott,
> > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > Lou
> > http://circ.ahjournals.org/content/1022/23/2836.full
> corrected:
> http://circ.ahjournals.org/content/102/23/2836.fullcorrection:
http://circ.ahajournals.org/content/102/23/2836.full
Posted by Solstice on February 28, 2012, at 11:34:47
In reply to corection: correction- Lou's reply-agranulocytosis, posted by Lou Pilder on February 27, 2012, at 23:02:28
Lou -
I guess you are aware that your link's Clinical Investigation reiterates what Scott said - that since Saphris is not activating the 5-HT2b receptors, it is not implicated in agranulocytosis.
Solstice
> > > Scott,
> > > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > > Lou
> > > http://circ.ahjournals.org/content/1022/23/2836.full
> > corrected:
> > http://circ.ahjournals.org/content/102/23/2836.full
>
> correction:
> http://circ.ahajournals.org/content/102/23/2836.full
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