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Re: Lou's request-pheytal » Lou Pilder

Posted by SLS on February 25, 2012, at 6:12:20

In reply to Lou's request-pheytal, posted by Lou Pilder on February 24, 2012, at 20:46:52

> Friends,
> Here is a link to a site that lists the effects of Saphris to the one taking he drug.I would like for interested readers to look a this in relation to adverse effects listed.
> Lou
> http://www.drugs.com/pro/saphris.html

Yup. Neuroleptics can be nasty drugs. They often give people back their lives, though. The neuroleptic I take causes in me weight gain and elevated triglycerides. These things are not very healthy, but are side effects I am more than willing to accept for the dramatic improvement in my quality of life the drug gives me. I do not suffer any of the other scary side effects listed.

When attempting to accurately evaluate the reported side effect profile of a drug, it is necessary to look at the frequency of occurrence of these effects by comparing the drug to placebo or the rate seen in the general population. The webpage you cite includes percentages of emergent side effects.

Rxlist uses charts:

http://www.rxlist.com/saphris-drug/side-effects-interactions.htm

Regarding the black box warning, people with Alzheimers Dementia seem to die at a higher rate when they take neuroleptic drugs related to Saphris, even though Saphris itself has not been reported to do so on Medline/Pubmed. Risperdal, haloperidol, chlorpromazine and trifluoperazine are the drugs that have received the most attention recently. These are relative old and high potency D2 agonist drugs. Not all antipsychotic medication carries the same risk of death in elderly populations. So, the warning is given for all members of the neuroleptic class of drugs out of prudence.

Neuroleptic antipsychotic drugs, when used in Alzheimers Dementia, doubles the risk of death from all causes after one year. Scientists don't know why yet. This is very sad. Still, in many cases, the benefits are deemed to outweigh the risks. Unfortunately, behavioral dyscontrol and psychosis are often present in Alzheimers patients.

When I blew out the candles for my fifth birthday, I didn't make a wish that I take neuroleptic antipsychotic drugs when I grew up.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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