Posted by Lou Pilder on February 27, 2012, at 22:10:29
In reply to Re: Lou's request-fenfluramine, posted by SLS on February 27, 2012, at 21:57:09
> > Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
>
> Okay.
>
> > Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> > This drug has been taken off the market
>
> Also, fenfluramine itself has been taken off of the market.
>
> > because of how it could cause heart disease and death.
>
> Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
>
> Fenfluramine is a dangerous drug.
>
> > Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
>
> To the best of my knowledge, this is misinformation.
>
> Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
>
> > So if you read the Saphris PI there could be the disclosure of possible agranulosis.
>
> To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
>
> Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
>
> > In the clinical trials, there were many deaths.
>
> To the best of my knowledge, this is misinformation.
>
> Please provide citations for this statement.
>
> Your use of the word "many" is an exagerration.
>
> To the best of my knowledge the 3-post rule still applies. Life is good.
>
>
> - ScottScott,
https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.html
poster:Lou Pilder
thread:1011122
URL: http://www.dr-bob.org/babble/20120221/msgs/1011866.html