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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by linkadge on July 27, 2010, at 19:11:48
Effexor, methyphenidate and ECT increase DHEA, wheras TCA's, lithium and SSRI's lower it. I wonder if this has any relavance to differing theraputic efficacy of these treatments?
Linkadge
Posted by linkadge on July 27, 2010, at 19:13:24
In reply to Differing AD effects on DHEA, posted by linkadge on July 27, 2010, at 19:11:48
Posted by morgan miller on July 28, 2010, at 10:45:43
In reply to Differing AD effects on DHEA, posted by linkadge on July 27, 2010, at 19:11:48
Guess it depends on whether you have high or low levels of DHEA to begin with.
It's interesting you bring this up as I have just recently decided to supplement with micronized DHEA.
I also just found out that lithium at higher doses may decrease levels of DHEA(we have to take into account that these were very high doses given to rats in the study). Funny, I currently take Prozac and lithium, but this is not the reason I started my DHEA supplementation.
In the past, I don't believe I noticed any effects while on SSRIs that would reflect possible lowering of DHEA levels.
I wonder if supplementing DHEA while on Lithium, TCA's, or SSRIs would ameliorate the effects of lower DHEA levels.
Posted by linkadge on July 28, 2010, at 13:49:01
In reply to Re: Differing AD effects on DHEA, posted by morgan miller on July 28, 2010, at 10:45:43
There has been more than one study on lithium on DHEA / DHEA-S levels. There was a in vivo, human study which concluded theraputic doses lower DHEA/S.
DHEA interacts with the sigma-1r receptor. Sigma agonists like DHEA have antidepressant and neuroprotective effects. Low DHEA could possibly produce apathy, low energy and/or sexual dysfunction.
OTOH, mania might be associated with elevated DHEA and hence this might be part of the antimanic effect of lithium.
Linkadge
Posted by europerep on July 28, 2010, at 13:58:41
In reply to Re: Differing AD effects on DHEA, posted by linkadge on July 28, 2010, at 13:49:01
sources?
Posted by morgan miller on July 28, 2010, at 15:36:46
In reply to Re: Differing AD effects on DHEA, posted by europerep on July 28, 2010, at 13:58:41
> sources?
google and pubmed are your friend : )
I couldn't find anything on SSRIs and DHEA. Wait! Found one on Amitriptyline and Paroxetine.
Posted by morgan miller on July 28, 2010, at 20:05:25
In reply to Differing AD effects on DHEA, posted by linkadge on July 27, 2010, at 19:11:48
Linkage, can you provide some sources for the lowering of DHEA by TCA's and SSRIs?
Posted by morgan miller on July 28, 2010, at 21:55:16
In reply to Re: Differing AD effects on DHEA, posted by morgan miller on July 28, 2010, at 20:05:25
Now I know I'm being annoying, but I would really love to see whatever study/studies show that all SSRIs and TCAs reduce levels of DHEA. So, where are the links, Link?
Posted by europerep on July 29, 2010, at 3:29:12
In reply to Re: Differing AD effects on DHEA, posted by morgan miller on July 28, 2010, at 21:55:16
of course google and pubmed are there - although scroogle is the preferable way to use google ;) - what I meant to say was just that it would be more easy and more convenient to post the links instead of having everyone who's interested look for them.. or are you hiding something, link? ;).. j/k..
Posted by morgan miller on July 29, 2010, at 9:48:00
In reply to Re: Differing AD effects on DHEA, posted by europerep on July 29, 2010, at 3:29:12
> of course google and pubmed are there - although scroogle is the preferable way to use google ;) - what I meant to say was just that it would be more easy and more convenient to post the links instead of having everyone who's interested look for them.. or are you hiding something, link? ;).. j/k..
Gotchya
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