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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Alejandro Ajedrez on July 20, 2010, at 21:52:21
Hi there-
Here's my current drug regimen:
EMSAM (Selegiline) patch 12 mg
Mirapex (Pramipexole) 1.5 mg
Solian (Amisulpride) 50 mg
Survector (Amineptine) 200 mg
Lamictal (Lamotrigine) 200 mgThis combination seems to be doing quite well to treat what I believe to be mild borderline personality disorder (or bipolar II, can't be sure) with anhedonia and dysthemia.
After trying and failing with the SSRIs, I tried wellbutrin with some luck (but too much cognitive impairment). This led me to believe that I may have a problem with dopamine or noradrenaline, not so much with serotonin. So I tried amineptine which proved mildly successful. So I thought it might be a dopamine issue, not so much noradrenaline. Then I added EMSAM, which seems to be working after about a month. Just in the last few days I've added Mirapex, and for these last few days I've felt just fine. Perhaps time will take away my euthymia, but we shall see.
I'm just worried that all this dopaminergic action could cause some serious problems like hypertension, tardive dyskinesia , etc. I feel great, and haven't noticed any hypertension yet. Could it be that it might take time before hypertension sets in? Also, amisulpride apparently can cause tardive dyskinesia at doses above 50 mg. I should be safe, but does the addition of all these other dopaminergic drugs increase my risk?
All questions and comments are appreciated.
Thank you,
Alejandro
Posted by bleauberry on July 21, 2010, at 15:56:43
In reply to Combine MAOI, Mirapex, Amisulpride, Amineptine?, posted by Alejandro Ajedrez on July 20, 2010, at 21:52:21
All good news. Glad it's looking up.
Puzzled though. How did you get Survector? I thought it was pulled years ago.
Posted by Alejandro Ajedrez on July 21, 2010, at 16:01:48
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine » Alejandro Ajedrez, posted by bleauberry on July 21, 2010, at 15:56:43
> All good news. Glad it's looking up.
>
> Puzzled though. How did you get Survector? I thought it was pulled years ago.Yeah, but it is still being custom manufactured. Quite expensive though. See http://amineptine.com/source/index.html
Posted by ed_uk2010 on July 21, 2010, at 16:40:01
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine » bleauberry, posted by Alejandro Ajedrez on July 21, 2010, at 16:01:48
> > All good news. Glad it's looking up.
> >
> > Puzzled though. How did you get Survector? I thought it was pulled years ago.
>
> Yeah, but it is still being custom manufactured. Quite expensive though. See http://amineptine.com/source/index.htmlManufactured by whom? Could be a counterfeit.
Posted by former poster on July 21, 2010, at 23:47:27
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine, posted by ed_uk2010 on July 21, 2010, at 16:40:01
I tried Emsam/Mirapex combo with some success. Amineptine really intrigues me because of being a stimulant and paradoxically improvement on sleep. I had the chance to try its cousin Tianeptine.
Posted by Alejandro Ajedrez on July 21, 2010, at 23:57:56
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine » ed_uk2010, posted by former poster on July 21, 2010, at 23:47:27
What'd you think about tianeptine?
Posted by former poster on July 22, 2010, at 0:29:51
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine, posted by Alejandro Ajedrez on July 21, 2010, at 23:57:56
Tianeptine.. I tried it only for 2-3 weeks. It had an astonishing effect on my sleep which felt wonderful to sleep SO DEEP!!! Then I started having nightmares. These nightmares were so real, usually involving a loved one dying. It was difficult to shake off the intense grief I felt even after being wide awake for several hours. I became afraid of sleep. After a few days felt like i was coming unraveled. I don't know why I should even think about trying it again? Maybe with a strong benzo dose? But there is evidence to suggest that it blocks the effects of Benzodiazepines
Posted by jade k on July 22, 2010, at 8:53:32
In reply to Combine MAOI, Mirapex, Amisulpride, Amineptine?, posted by Alejandro Ajedrez on July 20, 2010, at 21:52:21
> Hi there-
>
> Here's my current drug regimen:
> EMSAM (Selegiline) patch 12 mg
> Mirapex (Pramipexole) 1.5 mg
> Solian (Amisulpride) 50 mg
> Survector (Amineptine) 200 mg
> Lamictal (Lamotrigine) 200 mg
>
> This combination seems to be doing quite well to treat what I believe to be mild borderline personality disorder (or bipolar II, can't be sure) with anhedonia and dysthemia.
>
> After trying and failing with the SSRIs, I tried wellbutrin with some luck (but too much cognitive impairment). This led me to believe that I may have a problem with dopamine or noradrenaline, not so much with serotonin. So I tried amineptine which proved mildly successful. So I thought it might be a dopamine issue, not so much noradrenaline. Then I added EMSAM, which seems to be working after about a month. Just in the last few days I've added Mirapex, and for these last few days I've felt just fine. Perhaps time will take away my euthymia, but we shall see.
>
> I'm just worried that all this dopaminergic action could cause some serious problems like hypertension, tardive dyskinesia , etc. I feel great, and haven't noticed any hypertension yet. Could it be that it might take time before hypertension sets in? Also, amisulpride apparently can cause tardive dyskinesia at doses above 50 mg. I should be safe, but does the addition of all these other dopaminergic drugs increase my risk?
>
> All questions and comments are appreciated.
>
>
> Thank you,
> AlejandroHi Alejandro,
I haven't read the other posts, but yes, in my experience too much dopamine can cause problems. Delusions, paranoia, etc. I highly recommend you get a pdoc's opinion about what you are taking!
~Jade
Posted by former poster on July 24, 2010, at 0:57:02
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine?, posted by jade k on July 22, 2010, at 8:53:32
I wonder if low doses of all these would be safe? I had been prescribed Bupropion, Vyvanse, Mirapex and Emsam simultaneously. Only at half the maximum dose on the Mirapex and Emsam. I did feel overstimulated a few times. Can I ask what how much of a dose of Mirapex you take?
Posted by Alejandro Ajedrez on August 5, 2010, at 20:08:38
In reply to Re: Combine MAOI, Mirapex, Amisulpride, Amineptine? » jade k, posted by former poster on July 24, 2010, at 0:57:02
> I wonder if low doses of all these would be safe? I had been prescribed Bupropion, Vyvanse, Mirapex and Emsam simultaneously. Only at half the maximum dose on the Mirapex and Emsam. I did feel overstimulated a few times. Can I ask what how much of a dose of Mirapex you take?
I'm taking Emsam 12mg and Mirapex 1.5
How did you do on the Mirapex and Emsam? I would imagine that you'd feel over-stimulated on all this. Vyvanse is extremely stimulating at middle to high doses, and buproprion is quite stimulating for some (it was for me, but too many side effects.. it made me stupid).
Posted by rubyinparadise on October 1, 2010, at 12:18:41
In reply to Combine MAOI, Mirapex, Amisulpride, Amineptine?, posted by Alejandro Ajedrez on July 20, 2010, at 21:52:21
Hi there,
I'm having spectacular success on a very tiny dosage of selegiline. I've been on it now for about a month at 3-4mg/day, and I'm having an almost complete remission from my BPD symptoms: hypersensitivity to criticism and rejection, cognitive distortion, angry outbursts, self-hatred, unstable mood, chronic anxiety, social phobia, anxiety attacks, and suicidal depression. My relationships are stabilizing.
I have also suffered from Nightmare Disorder my entire life, and that is gone as well. The only other time I was able to manage my Nightmare Disorder was while on an SSRI.
My brother has been taking a combo of selegiline and prami for about six months, and also has had great results. He takes the selegiline in the morning because it has more of a mood-brightening, performance-enhancing and alertness effect, whereas the prami seems to have more of a sedative effect (perhaps paradoxical?)-- but he wakes up feeling amazing.
He is also on very low dosages of both drugs-- about 5mg of selegiline and 3mg of prami, and that has been the key for both of us. We get all the positive effects, and none of the side effects.
We have both tried SSRIs in the past, with mixed results. I took Paxil at 10mg for 9 years. I think it killed my dopamine receptors. It helped with my anxiety and depression and nightmare disorder, but it did not help at all with my BPD symptoms. And, I still had occasional anxiety attacks on it (but if I took more than 10mg, I felt very flat and emotionally disconnected).
Also, my memory was trashed and I was unable to feel strong positive emotions such as happiness, much less joy.
I feel like the selegiline is healing my dopamine receptors and stabilizing my dopamine level, possibly for the first time in my life. I am THRILLED. I am able to feel joy. People even respond differently to me.
The fact that such low dosages work for both me and my brother might be something genetic-- specific to our brain chemistry or metabolism. I don't know. All I know is that it is working incredibly well, and I am thrilled. A month ago, I just wanted to die. I feel like a completely different person.
This is the end of the thread.
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