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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Meltingpot on July 21, 2009, at 12:24:21
Sometimes when I feel as though everything is hopeless and that I'm never ever going to feel happy or excited or enthusiastic about anything ever again, I tell myself that maybe in 5 years time there will be better drugs on the market (I know it's sad to place my happines on a drug but that's the way it is.
However, when I look at the clinical trials site that there isn't many new types of drugs on the horizon and this makes me feel more despondent. How long does it take for a drug to get from phase II onto the market?
I just need a reason to hope.
Thanks.......Denise
Posted by Phillipa on July 21, 2009, at 12:56:10
In reply to Is there any reason to hope., posted by Meltingpot on July 21, 2009, at 12:24:21
Didn't you just get the new agomelatine released there? Good for anxiety and depression for a portion of those who have tried it. I know so many new meds for hearts and medical stuff. Love Phillipa
Posted by manic 666 on July 21, 2009, at 13:35:54
In reply to Is there any reason to hope., posted by Meltingpot on July 21, 2009, at 12:24:21
i have felt like that on an off 40 years, i have took a lot of meds, most well nearly all useless but you carnt have tried them all ,just keep ploughing on , i have a window in my illness now on sertraline 150mm how long for is anybodies guess,but at a price with side effects,it took , months to work , months of sh*t ,but i always stay the course even if like most bomb out.
Posted by Sigismund on July 21, 2009, at 15:16:06
In reply to Is there any reason to hope., posted by Meltingpot on July 21, 2009, at 12:24:21
Hi Denise
My gut response is that there is no hope, though I have had some success on
Agomelatine
Afobazol
Hydergine
Valium
and some supplements.
The first 3 drugs are unapproved in the Anglosphere, which is as I'd expect.
I wouldn't be expecting too much out of the current way of thinking, but that does not mean that thinking cannot change.
Posted by SLS on July 21, 2009, at 15:31:34
In reply to Is there any reason to hope., posted by Meltingpot on July 21, 2009, at 12:24:21
> Sometimes when I feel as though everything is hopeless and that I'm never ever going to feel happy or excited or enthusiastic about anything ever again,
Hope?
What would give you hope?
> I just need a reason to hope.
Keep trying. That you responded so well to paroxetine leads me to believe that you have the capacity to respond to something else - or even the same drug with untried adjuncts.
I am currently having success with:
Parnate 80mg
nortriptyline 150mg
Lamictal 200mg
Abilify 20mg
lithium 300mgHow did you respond to this combination?
There is your hope.
- Scott
Posted by maxime on July 21, 2009, at 19:13:30
In reply to Is there any reason to hope., posted by Meltingpot on July 21, 2009, at 12:24:21
Hi
I often lose hope myself. I have reacted badly to many meds and other ones just don't work. I was getting results with cymbalta, but now it doesn't work anymore and I don't know what to try.
I am always waiting for new meds to come out. And I live in Canada where it takes longer to get meds approved. We are still waiting for Abilify.
Just wanted you to know that you are not alone in your thinking. Hang in there.
Posted by SLS on July 21, 2009, at 20:06:40
In reply to Re: Is there any reason to hope. » Meltingpot, posted by maxime on July 21, 2009, at 19:13:30
Hi Maxime.
I'm glad you posted.
:-)
Just to let you know, I have been having success with adding lithium 300mg to my treatment regime.
I wish you only the best.
- Scott
Posted by linkadge on July 23, 2009, at 7:47:28
In reply to Re: Is there any reason to hope. » maxime, posted by SLS on July 21, 2009, at 20:06:40
I know the feeling that you're so low you put all of your hope in one thing.
Hopefully you can find releif enough that you can find joy in other things - until such a time as a more effective medication (or treatment) arives.
Its really going to be too long to wake up each morning wondering if a new med is out. I don't anticipate anything significant for another 15+ years.
There are probably meds or combo's you havn't tried yet. Or, even consider alternative supplements.
Linkadge
Posted by Meltingpot on July 26, 2009, at 12:12:21
In reply to Re: Is there any reason to hope. » Meltingpot, posted by Phillipa on July 21, 2009, at 12:56:10
Hi Phillipa,
Yes I have thought about agomelatine but then from what I've read it doesn't seem to have any more of antidepressant affect than the other ones which are already out on the market. I guess it would be worth a try though.
Denise
Posted by Meltingpot on July 26, 2009, at 12:14:50
In reply to Re: Is there any reason to hope., posted by manic 666 on July 21, 2009, at 13:35:54
Hi,
I'm glad the Sertraline has helped you, did it really take months to work. I've never had a drug that's suddenly started to work after months of being on it. Usually they start doing something in the first few weeks if they are going to do anything, otherwise they don't tend to work at all.
Denise
Posted by Meltingpot on July 26, 2009, at 12:16:43
In reply to Re: Is there any reason to hope., posted by Sigismund on July 21, 2009, at 15:16:06
Hi Sigismund,
Would you say that agomelatine is more effective as an antidepressant than the other SSRIs SNRIs or tryciclics on the market?
Denise
Posted by Meltingpot on July 26, 2009, at 12:24:53
In reply to Re: Is there any reason to hope. » Meltingpot, posted by SLS on July 21, 2009, at 15:31:34
Hi Scott,
Thanks for the positive comments :-) I'm not sure what would give me hope right now. The irony is that if I was taking something that was really working then I would probably feel hopeful but the fact that I'm still feeling mildly depressed makes me feel just generally hopeless.
My mum often asks me after I've been to see the psychiatrist "Are you happy now" and I say no, I won't feel happy until I'm taking something that actually works.
I might ask my private psychiatrist (I stress private because the one I've seen on the NHS has not helped me at all) if I can try a combination of a tricyclic and an MAOI, I've already tried lithium and lamictal separately and neither of them did very much. I've not tried abilify but I have a feeling, given my response to Zyprea that it would help me.
Thanks again for the encouraging words. I hope the positive experience you are having from the lithium will contine.
Denise
Posted by Meltingpot on July 26, 2009, at 12:27:34
In reply to Re: Is there any reason to hope. » Meltingpot, posted by maxime on July 21, 2009, at 19:13:30
Hi Maxime,
Thanks for the response, Its nice to know I'm not alone.
When did the Cymbalta stop working for you and what are you trying now? Wasn't it you who found Klonopin helpful?
Denise
Posted by Sigismund on July 27, 2009, at 22:21:16
In reply to Re: Is there any reason to hope - To Sigismund, posted by Meltingpot on July 26, 2009, at 12:16:43
>Would you say that agomelatine is more effective as an antidepressant than the other SSRIs SNRIs or tryciclics on the market?
I wouldn't be the best person to ask. It does have a very favourable s/e profile, so if that has been a problem for you, it could be good.
As I recall, you have a great deal of anxiety?
Are you the person for whom Paxil was great a long time ago? Doesn't matter. I get everyone mixed up.It is of some help to me. In particular my sleep is improved. And it is a natural kind of improvement. Perhaps in this way it is unique among available psych drugs.
The residual effect during the day is a kind of dopaminergic type feeling....fractionally euphoric, rather than mood elevating.
This is the end of the thread.
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