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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by jrbecker76 on April 27, 2009, at 22:56:10
I'm new to the Seroquel party line. So far, it hasn't been that welcoming. I've tried 12.5-25 mg for a week or so. Have only one side effect but it sure is a doozy... bad irritability and anger.
My original intention was to use it as a low-dose augmentor to replace Nefazodone and Rozerem for sleep and mood stability. However, the Seroquel is definitely not going to work out at this dosage level due to the anger issue. It somewhat reminds me of my experiences with Reboxetine, so perhaps it's the NE reuptake synergizing with the cymbalta i take. Pdoc thinks its an antihistaminergic reaction, but i'm doubtful of the accuracy of that assessment.
Two questions i have...
i) has anybody found that any irritability/anger issues were balanced out when ramping up to higher doses?
thinking of shooting for 75 - 100 mg
ii) i'm currently taking IR version. has XR shown to be a considerable difference to some?
Thanks in advance for the input.JB
Posted by Phillipa on April 27, 2009, at 23:39:17
In reply to Seroquel irritability at a low dose, posted by jrbecker76 on April 27, 2009, at 22:56:10
I couldn't tolerate even 50mg of it fell on my face in the am at the hospital. Strangely I could think but not talk. I do think some have posted of higher doses being more helpful. And hows it going other than that? Love Phillipa
Posted by SLS on April 28, 2009, at 7:28:31
In reply to Seroquel irritability at a low dose, posted by jrbecker76 on April 27, 2009, at 22:56:10
> I'm new to the Seroquel party line. So far, it hasn't been that welcoming. I've tried 12.5-25 mg for a week or so. Have only one side effect but it sure is a doozy... bad irritability and anger.
The reason I stopped taking Seroquel before two weeks had expired is that it was making me irritable. This was at a higher dosage, though. I don't remember exactly how much I was taking, but it was in excess of 100mg.
- Scott
Posted by johnj1 on April 28, 2009, at 8:57:25
In reply to Seroquel irritability at a low dose, posted by jrbecker76 on April 27, 2009, at 22:56:10
I took small doses for sleep and started at 12.5 then 25 mg. The first dose I took felt like my brain was taking a warm bath and sleep was ok. I developed some irritability on it and then it progressed to akathisia at the higher dose. It was clear to me that seroquel was not going to cut it as a long term solution for sleep even at small doses. I am very med sensitive so I have to really watch what I take. Was the nef and rozerem not working anymore?
I just started 10 mg of nortryptline for anxiety and sleep. Have you tried small doses of any tca's? I really should try anafranil since I have OCD.
Posted by zana on April 28, 2009, at 10:11:05
In reply to Re: Seroquel irritability at a low dose » jrbecker76, posted by johnj1 on April 28, 2009, at 8:57:25
I take 300mgs of seroquel. It was prescribed as an AD. It has had very modest AD effects and although it is supposed to be very sedating, I found it interferred with my sleep. As soon as I started taking it, I began to wake up after 6 hours. Before starting it, I was taking Remeron (45mgs) for sleep and would sleep like the dead for 9 hours.
I would consider Remeron. And I have been told it works as a sleep med at 15mgs.Zana
Posted by fattoush on April 28, 2009, at 19:12:49
In reply to Seroquel irritability at a low dose, posted by jrbecker76 on April 27, 2009, at 22:56:10
Didn't bother me at 25-50 mgs. At 150 then 200 mgs, I was going crazy, inner agitation, fear, anger, akathisia. Hated it.
Posted by jrbecker76 on April 30, 2009, at 15:44:57
In reply to Re: Seroquel irritability at a low dose, posted by fattoush on April 28, 2009, at 19:12:49
Updates...
good news is that there is less irritability now. bad news is that other side effects are quite bothersome....
I went for 75 mg two nights ago and ended up with the worst akathisia ever experienced. last night at 50 mg proved to be ok though. However, the larger problem I am noticing is that this drug seems to be increasing my rumination and overall instability. Every morning I wake up somewhat refreshed and cheery, but sometime after waking, I start ruminating and thinking negatively. I dont know why, maybe its more from being off Nefazodone than being on Seroquel. Or perhaps its Seroquel's short half-life and there's a bit of a rebound the next day. Regardless, my run with it is over.
Happily going back to Nefazodone and Rozerem.
JB
Posted by SLS on April 30, 2009, at 16:24:12
In reply to Re: Seroquel irritability at a low dose, posted by jrbecker76 on April 30, 2009, at 15:44:57
> Updates...
>
> good news is that there is less irritability now. bad news is that other side effects are quite bothersome....
>
> I went for 75 mg two nights ago and ended up with the worst akathisia ever experienced. last night at 50 mg proved to be ok though. However, the larger problem I am noticing is that this drug seems to be increasing my rumination and overall instability. Every morning I wake up somewhat refreshed and cheery, but sometime after waking, I start ruminating and thinking negatively. I dont know why, maybe its more from being off Nefazodone than being on Seroquel. Or perhaps its Seroquel's short half-life and there's a bit of a rebound the next day. Regardless, my run with it is over.
>
> Happily going back to Nefazodone and Rozerem.I'm sorry that the Seroquel didn't work out for you. I am guessing that the irritability comes from the pro-noradrenergic properties of the metabolite. Not all NE reuptake inhibitors are created equal. Desipramine has never made me feel worse. Reboxetine left me in an anxious suicidal state for over a week before I decided to discontinue it. I was okay within 36 hours. Atomoxetine is almost worthless as an antidepressant.
- Scott
Posted by Phillipa on April 30, 2009, at 22:45:48
In reply to Re: Seroquel irritability at a low dose, posted by jrbecker76 on April 30, 2009, at 15:44:57
Kind of the same with me and valium low dose and low dose luvox generic. Strange but I bet it's the withdrawal of the serzone as a pdoc here put me on incredibly high doses of benzos and didn't sleep for two weeks stopped the 50mg of luvox abuptly per his order. Went to ER and they said scratching there heards the doc that my body must need the luvox so go back on it and the valium did and slept again. Wierd? Phillipa
Posted by jrbecker76 on May 1, 2009, at 9:21:56
In reply to Re: Seroquel irritability at a low dose, posted by SLS on April 30, 2009, at 16:24:12
> > Updates...
> >
> > good news is that there is less irritability now. bad news is that other side effects are quite bothersome....
> >
> > I went for 75 mg two nights ago and ended up with the worst akathisia ever experienced. last night at 50 mg proved to be ok though. However, the larger problem I am noticing is that this drug seems to be increasing my rumination and overall instability. Every morning I wake up somewhat refreshed and cheery, but sometime after waking, I start ruminating and thinking negatively. I dont know why, maybe its more from being off Nefazodone than being on Seroquel. Or perhaps its Seroquel's short half-life and there's a bit of a rebound the next day. Regardless, my run with it is over.
> >
> > Happily going back to Nefazodone and Rozerem.
>
> I'm sorry that the Seroquel didn't work out for you. I am guessing that the irritability comes from the pro-noradrenergic properties of the metabolite. Not all NE reuptake inhibitors are created equal. Desipramine has never made me feel worse. Reboxetine left me in an anxious suicidal state for over a week before I decided to discontinue it. I was okay within 36 hours. Atomoxetine is almost worthless as an antidepressant.
>
> - ScottSS-
Interesting that my reactions to each of the NE reuptake inhibitors mirror your own.JB
Posted by Jeroen on May 3, 2009, at 14:51:21
In reply to Seroquel irritability at a low dose, posted by jrbecker76 on April 27, 2009, at 22:56:10
hi get it slowly upto 100 mg twice a day
wait for 2 weeks and magic things could happen to you :)
Posted by West on May 4, 2009, at 16:14:55
In reply to Re: Seroquel irritability at a low dose, posted by jrbecker76 on April 30, 2009, at 15:44:57
Isn't seroquel the antidrug for happiness.
I know from experience that my own dopamine is sufficiently low that taking something to further reduce it would be like willingly sending my self off to some swimming black and white auschwitch style nightmare populated by black crow men and pitch black mists
Posted by Jeroen on May 4, 2009, at 16:22:56
In reply to Re: Seroquel irritability at a low dose, posted by West on May 4, 2009, at 16:14:55
this one gave me relief for 2 months of pure happyness then it pooped out
Posted by metric on May 10, 2009, at 15:49:25
In reply to Re: Seroquel irritability at a low dose, posted by West on May 4, 2009, at 16:14:55
> Isn't seroquel the antidrug for happiness.
Well, almost. Drugs such as haloperidol are the prototypical antihappiness drugs. Seroquel is among the "new generation" antihappiness drugs, and it appears somewhat more benign in that respect. So I wouldn't call Seroquel *the* antidrug for happiness, but rather *an* antidrug for happiness.
> I know from experience that my own dopamine is sufficiently low that taking something to further reduce it would be like willingly sending my self off to some swimming black and white auschwitch style nightmare populated by black crow men and pitch black mists
If the acute adverse effects of neuroleptics ("antipsychotics") aren't enough of a deterrence, the well-known toxicity associated with their chronic use ought to be sufficient to discourage their use altogether.
This is the end of the thread.
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