Psycho-Babble Medication Thread 853148

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Selegine + DLPA = BIG disappointment for me

Posted by Amigan on September 20, 2008, at 17:41:10

I've been taking Selegiline for some time and it has basically pooped out. It was great at the first week but later, its effect started to slowly decline. I think it's because full MAO-B inhibition has been achieved and therefore there is not much point in taking more Selegiline until the body produces a certain amount of MAO-B again. What do you think?

Anyway, back on the subject:
I read nothing but good-to-excellent reports about the Selegiline + DLPA combination and so, i finally got some DLPA capsules to try it myself.
It was a big disappointment for me when i tried it and didn't feel anything at all. It was like i took placebo pills...
Why most people report feelings of "marked anxiety and insomnia", "great improvement in mood", etc and i have nothing to report. What did i do wrong or what is wrong with my neurochemistry?
Let's see:..
- I took 10mg of oral Selegiline after breakfast, as i'm supposed to.
- I waited for many hours without eating anything (as DLPA gets absorbed well only in an empty stomach) and took 1 capsule (500mg) of DLPA.
- After almost 1 hour, i took another capsule and this time, i combined it with a B-complex pill which contains 200mg of B6 (Pyridoxine) to help the absorption of DLPA.

So, why did it failed to give any results? Possible causes that i can think of:
- At first, i thought that the DLPA has expired because the bottle says that it expires at "1010" and i didn't know what this suppose to mean, but the pharmacist told me that it means the 10th month of 2010.
- I have never used a REAL stimulant. Thus, tolerance to stimulants should be excluded, imho.
- I drink a lot of coffee, though! Does caffeine produce cross-tolerance with other stimulants?? Does it "get in the way" to this combo? I would rather think that it should act synergically, but i'm not sure...
- Could the Prozac i took about 4 days ago interfered somehow? Personally, i doubt it as it works on Serotonin, while Selegiline/DLPA works on DA/NE, unless it has something to do with liver enzymes induction...

Your thoughts?

 

Re: Selegine + DLPA = BIG disappointment for me » Amigan

Posted by Sigismund on September 20, 2008, at 18:16:12

In reply to Selegine + DLPA = BIG disappointment for me, posted by Amigan on September 20, 2008, at 17:41:10

>I've been taking Selegiline for some time and it has basically pooped out. It was great at the first week but later, its effect started to slowly decline. I think it's because full MAO-B inhibition has been achieved and therefore there is not much point in taking more Selegiline until the body produces a certain amount of MAO-B again. What do you think?

Sounds odd. That is very quick to stop working...it has hardly had a chance to start....but I wouldn't know why it's stopped.

For a while I've been taking 500mg DLPA in the mornings (without selegeline) and that I can *just* notice and find helpful. 1g is quite noticeable, and not helpful.

I dunno. My insomnia was made worse by 1mg(!) of deprenyl citrate under the tongue every morning. Somehow it is stronger than selegeline, I think.

 

Re: Selegine + DLPA = BIG disappointment for me

Posted by azalea on September 20, 2008, at 20:55:53

In reply to Selegine + DLPA = BIG disappointment for me, posted by Amigan on September 20, 2008, at 17:41:10

10mg oral selegiline may be too low of a dose. This is the dose used for Parkinson's disease. Antidepressent (is that what you're taking it for?) dosing is generally 15-60mg/day.
I think 45mg/day is recommended, although everyone is different and you may respond at a different dose. At these higher doses, MAO-A is inhibited along with MAO-B, so the MAOI dietary restrictions should be followed.

> I've been taking Selegiline for some time and it has basically pooped out. It was great at the first week but later, its effect started to slowly decline. I think it's because full MAO-B inhibition has been achieved and therefore there is not much point in taking more Selegiline until the body produces a certain amount of MAO-B again. What do you think?

> - I took 10mg of oral Selegiline after breakfast, as i'm supposed to.

 

Re: Selegine + DLPA = BIG disappointment for me

Posted by Phillipa on September 21, 2008, at 0:16:25

In reply to Re: Selegine + DLPA = BIG disappointment for me, posted by azalea on September 20, 2008, at 20:55:53

Amigan sorry it pooped out on you will you up the dose or try something else? Love Phillipa

 

Re: Selegine + DLPA = BIG disappointment for me

Posted by Amigan on September 21, 2008, at 13:33:10

In reply to Re: Selegine + DLPA = BIG disappointment for me, posted by azalea on September 20, 2008, at 20:55:53

>10mg oral selegiline may be too low of a dose. This is the dose used for Parkinson's disease.

No. It's the average recommended dose for this combination. The purpose of Selegiline in this case is to destroy the MAO-B enzyme in order to stop the break down of PEA, which is produced from the metabolism of DLPA.
I think that a high dose of Selegiline might be dangerous when combined with DLPA, even if you adopt the MAOI diet.

 

Re: Selegine + DLPA = BIG disappointment for me

Posted by bleauberry on September 21, 2008, at 21:50:56

In reply to Selegine + DLPA = BIG disappointment for me, posted by Amigan on September 20, 2008, at 17:41:10

I thought the liquid deprenyl was a lot more reliable than the pills. My experience anyway.

DLPA can have immediate effects, but sometimes not. In old clinical studies it was dosed for up to a month before improvements were noted. In those studies only 150mg were used. On the internet some places claim up to 3000mg per day. So ya know, who knows. It is hit and miss self experimentation. But then, all of psychiatry is like that, so nothing new there.

Anyway, the first week improvement was probably feeling the extra NA and DA. The fact that it faded away doesn't mean it won't work. You perhaps felt something that was not the true therapuetic effect, which takes weeks or a couple months to happen. You felt a sudden rush of norepinephrine and dopamine. Now you are accustomed to it, and the rush is gone. But that rush was not the therapeutic effect. Brain adaptations have to take place, and that takes time. You might want to stick it out longer. 10mg by the way is not an adequate dose according to studies. You may need to get to 20mg to 30mg. Lay off the DLPA if you do that.

There are built-in governors by our genes that control how much tyrosine and/or phenylalanine get converted to norepinephrine/dopamine. Yours might be set in such a way as to not produce much, no matter how much of the raw ingredient you supply. Just a possibility. If that were true, then a higher dose of deprenyl would make sense.

Don't know. Just sharing some random thoughts on the subject for you to ponder.

 

Re: Selegine + DLPA = BIG disappointment for me

Posted by tecknohed on February 22, 2009, at 0:15:41

In reply to Re: Selegine + DLPA = BIG disappointment for me, posted by bleauberry on September 21, 2008, at 21:50:56

I take both Marplan (a non-reversable MAOI) top dose, AND 300mg/day of Wellbutrin (prolonged release) and now I've recently added 500mg DLPA in am + whenever required. The MAOI + Wellbutrin puzzled me as I thought NA would be steaming out my ears! But hypersomnia hung around.
Been on the combo 10 days and I cant keep the grin of my face lol . BIG change. Perhapse a full MAOI is more efficient at enabling fuller PEA upregulation/activity.
After reading about reboxetine + Parnate I'm guessing because of Wellbutrin's NRI effect it protects (through some mechanism- forgot what) against dangerously high BP by blocking the NA neurons from absorbing the excess NA that Tyramine & some drugs can cause.

Oops. sidetracking.

 

Re: Selegine + DLPA = BIG disappointment for me » tecknohed

Posted by Phillipa on February 22, 2009, at 19:53:37

In reply to Re: Selegine + DLPA = BIG disappointment for me, posted by tecknohed on February 22, 2009, at 0:15:41

Tech wow you're back!!!! Give me a ring. Love Phillipa


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