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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by trapper125 on April 28, 2007, at 22:56:41
While taking Emsam 12 mg I experienced moderate weight gain. Not that much but still unpleasant. I reduced to 6 mg and my weight has decreased. Has anyone experienced weight gain on Emsam and, if so, how much? What dose were you on? Has anyone experienced improvement on Emsam on 6mg or maybe 9 mg?
Posted by UgottaHaveHope on April 29, 2007, at 11:12:53
In reply to Emsam and weight gain, posted by trapper125 on April 28, 2007, at 22:56:41
Emsam is known for being "energizing" and you dont see a lot of ppl having any issues with weight gain. However, with that said, every med affects everybody differently. The X factor here is what other drugs you are taking with Emsam: They could cause weight gain in that combo.
Yes I took 6mg for three months and it really kicked around week 6-7. Felt like 6-7 on scale 1-10, but trying Nardil now to hit 10 for anxiety. We'll see what happens.
Keep on posting your thoughts and questions.
Posted by Phillipa on April 29, 2007, at 11:19:20
In reply to Possible, but you dont see it a lot » trapper125, posted by UgottaHaveHope on April 29, 2007, at 11:12:53
Robert David the first stayed at 6mg and didn't gain wt. He stopped as he just wanted some energy. On l.5mg of klonopin only now last I talked to him. Love Phillipa
Posted by jealibeanz on April 29, 2007, at 16:12:55
In reply to Emsam and weight gain, posted by trapper125 on April 28, 2007, at 22:56:41
> While taking Emsam 12 mg I experienced moderate weight gain. Not that much but still unpleasant. I reduced to 6 mg and my weight has decreased. Has anyone experienced weight gain on Emsam and, if so, how much? What dose were you on? Has anyone experienced improvement on Emsam on 6mg or maybe 9 mg?
This makes sense. At 6 mg it's usually only a MAOI-B inhibitor... which doesn't affect serotonin levels. It has MAOI-A inhibition at 12mg, maybe 9mg too... that increases the circulating serotonin, which is possibly a cause for weight gain.
Posted by Honore on April 29, 2007, at 17:05:06
In reply to Re: Emsam and weight gain » trapper125, posted by jealibeanz on April 29, 2007, at 16:12:55
It's a little too soon for speculations about weight gain and the possible effects on maoi-a and b at this point.
There could be lots of reasons- even if the Emsam was related to the weight gain. For example, there is transient anxiety-- so maybe you ate a little more for that reason and would ahve lost the weight eventually as you adapted. Or- are you sure, for example, that it was the Emsam that caused it? and that lowering the dose-- as opposed to trying a little harder to lose weight-- reversed the effect?
As for circulating serotonin, I'm not sure there's any evidence for that.
Honore
Posted by UgottaHaveHope on April 30, 2007, at 2:19:16
In reply to Re: Emsam and weight gain, posted by Honore on April 29, 2007, at 17:05:06
Jealibeanz, you have probably forgotten more about meds than I will ever know, but I will have to defer to Honore on this one. There is just not evidence to support that, and were likely other factors involved.
Posted by jealibeanz on April 30, 2007, at 5:10:05
In reply to I totally agree with you » Honore, posted by UgottaHaveHope on April 30, 2007, at 2:19:16
> Jealibeanz, you have probably forgotten more about meds than I will ever know, but I will have to defer to Honore on this one. There is just not evidence to support that, and were likely other factors involved.
I'm definitely no expert on MAOI's, but isn't it true that one difference between MAOI-A and MAOI-B inhibition is that A inhibits the enzymes that break down serotonin?I don't think that one can pinpoint that as being the cause of a side effect, it's just one piece in the puzzle, which may or may not be a factor.
This is the end of the thread.
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