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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by football on March 30, 2007, at 20:46:03
I was worried that I would gain weight like crazy after starting Nardil, but to my relief and surprise, I have actually less of an appetite then even when I was taking Adderall!
Makes me happy, because I could afford to lose 10-15 LBS!
Posted by Phillipa on March 30, 2007, at 20:55:32
In reply to Nardil and weight gain? Um... no!, posted by football on March 30, 2007, at 20:46:03
Football well that's good news for you. Love Phillipa
Posted by FredPotter on April 1, 2007, at 23:28:41
In reply to Re: Nardil and weight gain? Um... no! » football, posted by Phillipa on March 30, 2007, at 20:55:32
I read that the antidiabetic drug Metformin can prevent weight gain with Nardil. First you have to convince your Dr you're diabetic. A Kg of chocolate before the appointment should do it
Posted by FredPotter on April 2, 2007, at 16:22:35
In reply to Re: Nardil and weight gain? Um... no! » Phillipa, posted by FredPotter on April 1, 2007, at 23:28:41
I'm just coming up to 2 weeks on Nardil 15mg 3 times per day. I must admit I feel groggy and sedated, esp in the morning. Does anyone know if this goes away, or if there is anything that takes it away (eg Periactin)? Someone posted a warning about taking some antihistamines with Nardil, but I wasn't clear if this included Periactin. Can some knowledgeable person please help?
I've been dysphoric this last week (I came off Effexor cold-turkey nearly 3 weeks ago). Dysphoric I take to mean hypomanic and angry. I wonder if this is Effexor withdrawal or starting Nardil.
Mind you the people I got angry with deserved it. People at work expecting unreasonable things (cos their work's more important than other people's); my wife who deserted me when I was very sick; people who tout cures that don't work. So not manic, merely hypomanic, but dysphoria is not a nice state
Thanks Fred
Posted by Iansf on April 3, 2007, at 15:54:55
In reply to Re: Nardil, grogginess, Periactin, dysphoria, posted by FredPotter on April 2, 2007, at 16:22:35
Try to bear with the Nardil sleepiness. Sleep disruption (whether insomnia or hypersomnia) is common when starting MAOIs. For most people, the problem disappears in 4 to 6 weeks.
Typically antihistamines make you sleepy, not wakeful. And it's not antihistamines you have to worry about with Nardil (and other MAOIs), it's decongestants (like pseudophed). People often get confused about this because you're warned not to take cold medications. But that's because cold medications generally have both antihistamines and decongestants in them. Decongestants are ABSOLUTELY OFF LIMITS!
> I'm just coming up to 2 weeks on Nardil 15mg 3 times per day. I must admit I feel groggy and sedated, esp in the morning. Does anyone know if this goes away, or if there is anything that takes it away (eg Periactin)? Someone posted a warning about taking some antihistamines with Nardil, but I wasn't clear if this included Periactin. Can some knowledgeable person please help?
>
> I've been dysphoric this last week (I came off Effexor cold-turkey nearly 3 weeks ago). Dysphoric I take to mean hypomanic and angry. I wonder if this is Effexor withdrawal or starting Nardil.
>
> Mind you the people I got angry with deserved it. People at work expecting unreasonable things (cos their work's more important than other people's); my wife who deserted me when I was very sick; people who tout cures that don't work. So not manic, merely hypomanic, but dysphoria is not a nice state
> Thanks Fred
Posted by Quintal on April 3, 2007, at 16:18:01
In reply to Re: Nardil, grogginess, Periactin, dysphoria, posted by FredPotter on April 2, 2007, at 16:22:35
Yes, Periactin is very sedating Fred - its main use with Nardil is that it blocks 5-HT2 receptors, preventing Nardil from overstimulating them which is the cause of the anorgasmia. I can't remember why, something to do with dopamine being downregulated, perhaps the D2 receptors (?) since cabergoline (which is pro-orgasmic and can eliminate the male refractory period) is an agonist of D2 receptors. I'm wondering if there's an axis of some sort i.e. a 5-HT2/D2 seesaw where you press hard on one end and the other goes up? Maybe.
Some people add Wellbutrin to Nardil for its stimulant and pro-sexual effects. I've been wondering if you can add reboxetine since it's a clean med and I'm doing well on it so far. Wellbutrin should be fine though. I think some of the noradrenergic TCAs might add to the grogginess and cognitive impairment, so my vote would be for Wellbutrin/reboxetine (if it's safe). Some people add stims like Ritalin and Dexedrine, but they're more risky.
Q
Posted by FredPotter on April 3, 2007, at 18:38:10
In reply to Re: Nardil, grogginess, Periactin, dysphoria » FredPotter, posted by Quintal on April 3, 2007, at 16:18:01
Thanks. It's complicated eh? Meanwhile I want some Cabergoline - tons of it
Posted by FredPotter on April 3, 2007, at 20:14:36
In reply to Re: Nardil, grogginess, Periactin, dysphoria » FredPotter, posted by Iansf on April 3, 2007, at 15:54:55
That's a very important post. Many thanks. I'm just at the end of week 2 so I can stick out. It's seems to be a morning thing. Strangely a lot of the rest of the time I'm all speeded up, which can lead to feeling good, or impatient and dysphoric. I don't "take it" from anyone - a change from that apology for a wimp of a human being that I was
Fred
Posted by FredPotter on April 3, 2007, at 20:26:35
In reply to Re: Nardil, grogginess, Periactin, dysphoria » FredPotter, posted by Quintal on April 3, 2007, at 16:18:01
Thanks. I have some Wellbutrin in my bulging medicine cabinet. I'll try it and stay away from the Periactin. Cabergoline sounds fun though.
Fred
Posted by Quintal on April 3, 2007, at 20:53:03
In reply to Re: Nardil, grogginess, Periactin, dysphoria » Quintal, posted by FredPotter on April 3, 2007, at 20:26:35
Yes, but be careful with it and take it slowly Fred. I haven't actually taken it myself or followed anyone who has done it very closely. You might want to start a new thread and get some more advice before taking the plunge.
I've never tried cabergoline but pramipexole is certainly good for your sex life. I had the most impressive toe-curling convulsive orgasm just two hours ago after taking my night time dose, and after only the lightest stimulation. It's like being a teenager again, the slightest vibration can set me off. No wonder the Parkinson's patients at the nursing home I used to work in were so randy. We'd often find the men wandering the corridors going from room to room, looking for a potential mate. On some occasions they were successful........usually their female fellow Parkinson's sufferers were most receptive.
Q
This is the end of the thread.
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