Psycho-Babble Medication Thread 744779

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Is Lyrica hard on the Liver?

Posted by Crazy Horse on March 27, 2007, at 19:21:30

I was taking Lyrica 300 mgs. bid, my GP told me we have to reduce it to 300mgs. a day, he said at 600 a day it may cause liver Damage. Is this true? What sucks is that Lyrica at 300 bid works beautifully for anxiety. At 300 a day i feel no help from the drug.

-Monte

Re: Is Lyrica hard on the Liver? » Crazy Horse

Posted by Phillipa on March 27, 2007, at 20:20:49

In reply to Is Lyrica hard on the Liver?, posted by Crazy Horse on March 27, 2007, at 19:21:30

Monte what's it say on google? Love Phillipa

Re: Is Lyrica hard on the Liver? » Crazy Horse

Posted by Larry Hoover on March 28, 2007, at 8:02:18

In reply to Is Lyrica hard on the Liver?, posted by Crazy Horse on March 27, 2007, at 19:21:30

> I was taking Lyrica 300 mgs. bid, my GP told me we have to reduce it to 300mgs. a day, he said at 600 a day it may cause liver Damage. Is this true? What sucks is that Lyrica at 300 bid works beautifully for anxiety. At 300 a day i feel no help from the drug.
>
> -Monte

I can't explain your doctor's concerns. Lyrica is almost completely devoid of liver interaction, with the major liver metabolite constituting less than 1% of the total drug excreted. Total liver interaction is thought to be less than 2%. There is no FDA warning. There isn't even a restriction or contraindication noted for those with known liver disease. Nothing in the monograph, except a notation in the uncommon side effects list of increased liver enzymes. Nothing in Pubmed. I think he may have made a mistake. Absent demonstrated increases in liver enzymes in your body....or did you have those?

Lar

Re: Is Lyrica hard on the Liver?

Posted by Crazy Horse on March 28, 2007, at 13:52:09

In reply to Re: Is Lyrica hard on the Liver? » Crazy Horse, posted by Larry Hoover on March 28, 2007, at 8:02:18

> > I was taking Lyrica 300 mgs. bid, my GP told me we have to reduce it to 300mgs. a day, he said at 600 a day it may cause liver Damage. Is this true? What sucks is that Lyrica at 300 bid works beautifully for anxiety. At 300 a day i feel no help from the drug.
> >
> > -Monte
>
> I can't explain your doctor's concerns. Lyrica is almost completely devoid of liver interaction, with the major liver metabolite constituting less than 1% of the total drug excreted. Total liver interaction is thought to be less than 2%. There is no FDA warning. There isn't even a restriction or contraindication noted for those with known liver disease. Nothing in the monograph, except a notation in the uncommon side effects list of increased liver enzymes. Nothing in Pubmed. I think he may have made a mistake. Absent demonstrated increases in liver enzymes in your body....or did you have those?
>
> Lar
>

No, i have not had an increase in liver enzymes in my body. I think you're right, he made a mistake. Thanks Lar.

-Monte

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