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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Brutus1 on March 19, 2007, at 11:16:27
What really is the diffence between the two in terms of Dopmamine and norepinephrine reuptake?
MPH is a dopamine reuptake inhibitor, which means that it increases the level of the dopamine neurotransmitter in the brain by partially blocking the transporters that remove it from the synapses.[11
Bupropion is a selective catecholamine (dopamine and norepinephrine) reuptake inhibitor. It has a small effect, if any, on the serotonin reuptake mechanism. It has however been shown to indirectly enhance firing of serotonergic neurons (via activation of downstream norepinephrine flow). Bupropion does not inhibit MAO (i.e. is not a MAOI). The antidepressant effect of bupropion is considered to be mediated primarily by its dopaminergic and noradrenergic action. Bupropion has also been shown to act as a competitive α3β4 nicotinic antagonist; the α3β4-antagonism has been shown to interrupt certain addictions in studies of other drugs such as ibogaine. This α3β4-antagonism correlates quite well with the observed effect of interrupting addiction.
Posted by Phillipa on March 19, 2007, at 14:32:51
In reply to Mode of action, MPH (Ritalin) and Buproprion., posted by Brutus1 on March 19, 2007, at 11:16:27
Mind if I follow your thread your knowledge is beyond mine. Love Phillipa
Posted by med_empowered on March 19, 2007, at 15:30:41
In reply to Mode of action, MPH (Ritalin) and Buproprion., posted by Brutus1 on March 19, 2007, at 11:16:27
Wellbutrin is pretty stimulant-ish (its like a mild version of Tenuate), but I think there differences. For one, b/c of the reuptake inhibition, wellbutrin reduces dopamine release, which is something a lot of ADs do. This is also why you can sometimes combine it with antipsychotics w/ good results. MPH does reuptake inhibition but, as far as I know, doesn't have any major impact on dopamine release. Its also sometimes used in schizophrenia, with stable patients with a lot of negative symptoms, or stable patients mired in drug-induced sedation (like with clozapine).
Posted by Brutus1 on March 19, 2007, at 18:29:18
In reply to Re: Mode of action, MPH (Ritalin) and Buproprion. » Brutus1, posted by Phillipa on March 19, 2007, at 14:32:51
> Mind if I follow your thread your knowledge is beyond mine. Love Phillipa
My knowledge is only a fraction of what med_empowered and many other posters posess. Besides you know more than you think :) How is the Xanax XR? No AD's correct?
Posted by Brutus1 on March 19, 2007, at 18:37:18
In reply to Re: Mode of action, MPH (Ritalin) and Buproprion., posted by med_empowered on March 19, 2007, at 15:30:41
Thanks. Some beleive MPH might also hit the H1 (Serotonin) receptors downstream also? Do you still take Dex?
B
> Wellbutrin is pretty stimulant-ish (its like a mild version of Tenuate), but I think there differences. For one, b/c of the reuptake inhibition, wellbutrin reduces dopamine release, which is something a lot of ADs do. This is also why you can sometimes combine it with antipsychotics w/ good results. MPH does reuptake inhibition but, as far as I know, doesn't have any major impact on dopamine release. Its also sometimes used in schizophrenia, with stable patients with a lot of negative symptoms, or stable patients mired in drug-induced sedation (like with clozapine).
>
>
Posted by Phillipa on March 19, 2007, at 20:27:26
In reply to Re: Mode of action, MPH (Ritalin) and Buproprion., posted by Brutus1 on March 19, 2007, at 18:29:18
Well considering I forgot to take lunesta last night and slept it must be doing something and down from 20mg of valium to 5mg and tonight no luvox. Love Phillipa ps thanks for asking
This is the end of the thread.
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