Posted by Brutus1 on March 19, 2007, at 11:16:27
What really is the diffence between the two in terms of Dopmamine and norepinephrine reuptake?
MPH is a dopamine reuptake inhibitor, which means that it increases the level of the dopamine neurotransmitter in the brain by partially blocking the transporters that remove it from the synapses.[11
Bupropion is a selective catecholamine (dopamine and norepinephrine) reuptake inhibitor. It has a small effect, if any, on the serotonin reuptake mechanism. It has however been shown to indirectly enhance firing of serotonergic neurons (via activation of downstream norepinephrine flow). Bupropion does not inhibit MAO (i.e. is not a MAOI). The antidepressant effect of bupropion is considered to be mediated primarily by its dopaminergic and noradrenergic action. Bupropion has also been shown to act as a competitive α3β4 nicotinic antagonist; the α3β4-antagonism has been shown to interrupt certain addictions in studies of other drugs such as ibogaine. This α3β4-antagonism correlates quite well with the observed effect of interrupting addiction.
poster:Brutus1
thread:742117
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