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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by starfox on March 17, 2007, at 6:47:56
Hi everyone,
Did you know that pfizer has discontinued the tricyclic drug Sinequan (Doxepin). Apparently they are no longer making money from this drug so they have stopped making it. Doxepin has helped me quite alot over the years with insomnia and depression as im sure it has helped many people all over the world. Does anyone know if the generic versions of doxepin will still be available?
Posted by linkadge on March 17, 2007, at 7:27:01
In reply to SINEQUAN (DOXEPIN) IS DISCONTINUED!!!, posted by starfox on March 17, 2007, at 6:47:56
This sucks. I hope, like you say, there will still be a generic available. Granted, these aren't money makers anymore, but I would assume there would be a number of people who respond to TCA's but not other drugs.
Linkadge
Posted by Phillipa on March 17, 2007, at 9:34:17
In reply to Re: SINEQUAN (DOXEPIN) IS DISCONTINUED!!!, posted by linkadge on March 17, 2007, at 7:27:01
Link was it a popular TCA? Love Phillipa
Posted by yxibow on March 17, 2007, at 11:43:35
In reply to SINEQUAN (DOXEPIN) IS DISCONTINUED!!!, posted by starfox on March 17, 2007, at 6:47:56
Most all TCAs are probably discontinued or are going to be discontinued by their manufacturer, considering the first one, Tofranil (a huh ? would probably come up for even the brand name -- its imipramine), was marketed around 1958.
They've been generic and have been so for some time. My mother has been using generic doxepin for ages for angioedema allergies -- its the only or one of few agents that strongly covers H1 and H2. Watson and Mylan makes generic doxepin in the US.
I think you're referring to an issue in NHS and Commonwealth marketing territories. It is true that Pfizer discontinued it, but there was to be an agreement that Marlborough Pharmaceuticals was to manufacture the tablets.
-- tidings
Posted by sukarno on March 19, 2007, at 14:04:26
In reply to Re: SINEQUAN (DOXEPIN) IS DISCONTINUED!!! » starfox, posted by yxibow on March 17, 2007, at 11:43:35
"its the only or one of few agents that strongly covers H1 and H2"
I'm curious... How is this agent compared to other antihistamines? You said it covers H2 also, so would it be of use in acid reflux disease?
Thanks! :-)
Paul
Posted by yxibow on March 19, 2007, at 15:24:24
In reply to Re: SINEQUAN (DOXEPIN) IS DISCONTINUED!!!, posted by sukarno on March 19, 2007, at 14:04:26
> "its the only or one of few agents that strongly covers H1 and H2"
>
> I'm curious... How is this agent compared to other antihistamines? You said it covers H2 also, so would it be of use in acid reflux disease?
>
> Thanks! :-)
>
> PaulYes, it is strongest at H1 and H2, also Trimipramine is fairly strong.
I had searched around and there aren't references to it being used as Zantac has been used; on the other hand oppositely, Zantac has been used in acute allergies.
e.g. http://www.respiratoryreviews.com/jan01/rr_jan01_H1andH2blockade.html
It has been used for a more rare disorder called mastocystis.So the answer is, you would have to ask your allergist, but I believe Zantac et alia are more targeted towards stomach secretion.
This is the end of the thread.
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