Psycho-Babble Medication Thread 732596

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Remeron and receptors

Posted by saturn on February 13, 2007, at 21:50:02

Is it correct that Remeron first hits H1, then 5-HT2 and 5-HT3 and then later on alpha-1 NE?

I'm wondering if the following might be about right:

7.5 mg---mainly H1 blocked
15 mg---H1 and 5-HT2/5-HT3 blocked
30 mg and up---H1, 5-HT2/5-HT3 and NE alpha-1 blocked?

Also, does Remeron increase synaptic serotonin at all or are the serotonin effects just the 5-HT2/3 antagonism?

Thanks...Peace...Saturn.

Re: Remeron and receptors » saturn

Posted by yxibow on February 14, 2007, at 17:12:17

In reply to Remeron and receptors, posted by saturn on February 13, 2007, at 21:50:02

> Is it correct that Remeron first hits H1, then 5-HT2 and 5-HT3 and then later on alpha-1 NE?
>
> I'm wondering if the following might be about right:
>
> 7.5 mg---mainly H1 blocked
> 15 mg---H1 and 5-HT2/5-HT3 blocked
> 30 mg and up---H1, 5-HT2/5-HT3 and NE alpha-1 blocked?
>
> Also, does Remeron increase synaptic serotonin at all or are the serotonin effects just the 5-HT2/3 antagonism?
>
> Thanks...Peace...Saturn.

I thought the 5HT blockade occurred later on after the alpha adrenergic action which is the primary action of Remeron. But I know that the 5HT was important to me and I got up to 52.5, which was a bit too much and backed to 45. Then there was the weight....

Re: Remeron and receptors

Posted by linkadge on February 14, 2007, at 17:15:44

In reply to Remeron and receptors, posted by saturn on February 13, 2007, at 21:50:02

>Also, does Remeron increase synaptic serotonin >at all or are the serotonin effects just the 5->HT2/3 antagonism?

Not sure about the relative affinities. I think you probably have the order right. Yes, I think Remeron does increase hippocampal serotonin. The alpha-2 heteroreceptor blockade affects serotonin release I believe. I also think that the serotonin blockade indirectly leads to greater 5-ht agonism at 5-ht1a.

Linkadge

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