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Re: Remeron and receptors

Posted by linkadge on February 14, 2007, at 17:15:44

In reply to Remeron and receptors, posted by saturn on February 13, 2007, at 21:50:02

>Also, does Remeron increase synaptic serotonin >at all or are the serotonin effects just the 5->HT2/3 antagonism?

Not sure about the relative affinities. I think you probably have the order right. Yes, I think Remeron does increase hippocampal serotonin. The alpha-2 heteroreceptor blockade affects serotonin release I believe. I also think that the serotonin blockade indirectly leads to greater 5-ht agonism at 5-ht1a.


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