Posted by linkadge on February 14, 2007, at 17:15:44
In reply to Remeron and receptors, posted by saturn on February 13, 2007, at 21:50:02
>Also, does Remeron increase synaptic serotonin >at all or are the serotonin effects just the 5->HT2/3 antagonism?
Not sure about the relative affinities. I think you probably have the order right. Yes, I think Remeron does increase hippocampal serotonin. The alpha-2 heteroreceptor blockade affects serotonin release I believe. I also think that the serotonin blockade indirectly leads to greater 5-ht agonism at 5-ht1a.
Linkadge
poster:linkadge
thread:732596
URL: http://www.dr-bob.org/babble/20070213/msgs/732819.html