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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by linkadge on December 6, 2006, at 16:55:51
?
Linkadge
Posted by yxibow on December 6, 2006, at 20:33:57
In reply to can remeron be combined with MAOI's?, posted by linkadge on December 6, 2006, at 16:55:51
> ?
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> LinkadgeThe drugs.com drug interaction checker at http://www.drugs.com/drug_interactions.html gives it a red flag warning with Parnate so I'd say probably not but maybe someone has tried it. Remeron is somewhat serotonergic.
Posted by elanor roosevelt on December 6, 2006, at 20:48:05
In reply to Re: can remeron be combined with MAOI's?, posted by yxibow on December 6, 2006, at 20:33:57
no
side effects are pretty serious with parnate
see your pdoc
Posted by willyee on December 6, 2006, at 23:05:02
In reply to can remeron be combined with MAOI's?, posted by linkadge on December 6, 2006, at 16:55:51
> ?
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> LinkadgeBeen there,done that,initialy extreme benifit then the sedation was no longer held back.
Aside from the usual discomfort of Remeron,i dident notice any serious interaction at all,this is not to say i give a green light to try it of course,but im sure link you know that.Just my exper.
Posted by Tom Twilight on December 7, 2006, at 7:49:30
In reply to Re: can remeron be combined with MAOI's?, posted by willyee on December 6, 2006, at 23:05:02
I've tried combining Remeron with MAOIs with the following results.
Remeron seems to be OK with Marplan provided I went for a low dose-say 7.5mg.
I felt very stimulated but also kind of Euphoric
I imagine combination with Nardil would be similar.Tried combining Remeron with Parnate and felt very unwell, pounding heart e.c.t. really frustrating but I don't think its a good idea!
Posted by psychobot5000 on December 7, 2006, at 22:00:31
In reply to can remeron be combined with MAOI's?, posted by linkadge on December 6, 2006, at 16:55:51
> ?
I got a consult done once, with a medical professor who was an MAOI expert, and (despite labeling restrictions) he told me firmly that Remeron had been found safe to use with MAOIs. In my written consult, he specifically recommended it in combination with them as a useful and powerful augmentation strategy. The dosage of the Remeron need not be restricted, either.I have read that Remeron can be used acutely to treat serotonin syndrome, I presume because of its receptor antagonist effects (?). This may be part of why it's not dangerous in terms of hyperpyretic crises. The same doctor considers most tricyclics (NOT clomipromine, possibly not trimipramine) a possibility to use in combination with MAOIs, as long as it is monitored carefully. I have found at least one article recommending the same (despite all the labeling warnings).
Posted by Declan on December 8, 2006, at 2:55:49
In reply to Re: can remeron be combined with MAOI's?, posted by Tom Twilight on December 7, 2006, at 7:49:30
I could imagine low/medium dose selegeline plus just enough Remeron to sleep.
Posted by linkadge on December 8, 2006, at 10:41:11
In reply to Re: can remeron be combined with MAOI's?, posted by Declan on December 8, 2006, at 2:55:49
The drug yohimbine is a MAOI, and an alpha-2 antagonist like remeron.
Linkadge
Posted by SLS on December 8, 2006, at 12:44:07
In reply to Remeron MAOi augmentation? Yes., posted by psychobot5000 on December 7, 2006, at 22:00:31
The same doctor considers most tricyclics (NOT clomipromine, possibly not trimipramine) a possibility to use in combination with MAOIs, as long as it is monitored carefully. I have found at least one article recommending the same (despite all the labeling warnings).
I have had problems mixing Nardil, but not Parnate, with imipramine. The reaction was presumed to be serotonin syndrome and included severe hypotension and muscle rigidity along with some mental confusion. Nardil in combination with desipramine or nortriptyline doesn't affect me that way.
- Scott
Posted by dbc on December 8, 2006, at 21:23:50
In reply to Re: Remeron MAOi augmentation? Yes., posted by SLS on December 8, 2006, at 12:44:07
Given Remerons not really understood serotonin drug potenating properties i would say no. Its unclear how some aspects of remeron works still and really i wouldnt risk my life over it.
Posted by psychobot5000 on December 9, 2006, at 12:25:39
In reply to Re: Remeron MAOi augmentation?, posted by dbc on December 8, 2006, at 21:23:50
Remeron has been used successfully to treat serotonin syndrome. It would, then, seem unlikely that it would cause it.
Posted by Oppycat on December 10, 2006, at 12:08:26
In reply to can remeron be combined with MAOI's?, posted by linkadge on December 6, 2006, at 16:55:51
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> LinkadgeI am ready to go back on Remeron after not responding to Parnate this time although I used it successfully for many years. I had good results with Remeron earlier this year for about 6 six months.
I gave it up because it magnified all of my vices and I ate too much (doesn't everyone on Remeron), drank too much, and found it almost impossible to get up in the morning. My blood sugar went up and so did my cholersterol. This is not good when you are a diabetic with cardiac issues. On the positive side, my sex life was wonderful, which I (and my girlfriend) really miss.
I don't plan to use Remeron and Parnate together, but I would like to switch to Remeron without waiting the usual 2 weeks. Does anyone think I can hasten the washout?
Michael
Posted by linkadge on December 11, 2006, at 17:08:41
In reply to Re: can remeron be combined with MAOI's? » linkadge, posted by Oppycat on December 10, 2006, at 12:08:26
Remeron doesn't appear to have any effects on the metabolism of serotonin. It may effect serotonin release, but then so does amphetamine, which has been combined with MAOI's.
Linkadge
This is the end of the thread.
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