Psycho-Babble Medication Thread 686123

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DA-releasing information on PDSP?

Posted by Keith Talent on September 15, 2006, at 4:05:57

Hi everyone,

Does anyone know how to get data on the dopamine-releasing properties of drugs from the PDSP (Psychoactive Drug Screening Program) website? I'm specifically interested in dextroamphetamine versus methylphenidate, but can't see any obvious way to extract these data. I'm interested to know because I think that the results may have implications for the sustainability of therapeutic benefits with these agents. Thanks,

KT

 

Re: DA-releasing information on PDSP?

Posted by dbc on September 15, 2006, at 5:21:54

In reply to DA-releasing information on PDSP?, posted by Keith Talent on September 15, 2006, at 4:05:57

All i can give you is ancedotal evidence. D-amphetamine is much more potent dopamine wise than methylphenidate, the fact that (ritalin) is a racemic mixture would also lead me to this conclusion. Though relatively recently theres been a product released called focalin thats pure D-methylphenidate so that may cause quite a difference in dopamine release in higher doses. (the Levo isomer in ritalin/adderall is pretty damn useless and serves mostly as a cardiovascular stimulant).

 

Re: DA-releasing information on PDSP?

Posted by linkadge on September 15, 2006, at 6:43:12

In reply to Re: DA-releasing information on PDSP?, posted by dbc on September 15, 2006, at 5:21:54

I don't know if PDSP has data for DA releasing properties, since I think it deals mainly with receptor affinities as antagonists or agonists.

You can find the affinity for DA reuptake however, under dopamine transporter.

Linkadge

 

Re: DA-releasing information on PDSP?

Posted by SLS on September 15, 2006, at 7:42:03

In reply to DA-releasing information on PDSP?, posted by Keith Talent on September 15, 2006, at 4:05:57

> Hi everyone,
>
> Does anyone know how to get data on the dopamine-releasing properties of drugs from the PDSP (Psychoactive Drug Screening Program) website? I'm specifically interested in dextroamphetamine versus methylphenidate, but can't see any obvious way to extract these data. I'm interested to know because I think that the results may have implications for the sustainability of therapeutic benefits with these agents. Thanks,

I think amphetamine results in greater and more sustained DA release as it releases DA from both storage vesicles and newly synthesized DA in the cytosol. Methylphenidate releases from vesicles only.


- Scott

 

Re: DA-releasing information on PDSP?

Posted by Keith Talent on September 16, 2006, at 6:40:28

In reply to Re: DA-releasing information on PDSP?, posted by SLS on September 15, 2006, at 7:42:03

I'd already seen the data on DAT inhibition. Thanks everyone.


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