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Re: DA-releasing information on PDSP?

Posted by SLS on September 15, 2006, at 7:42:03

In reply to DA-releasing information on PDSP?, posted by Keith Talent on September 15, 2006, at 4:05:57

> Hi everyone,
>
> Does anyone know how to get data on the dopamine-releasing properties of drugs from the PDSP (Psychoactive Drug Screening Program) website? I'm specifically interested in dextroamphetamine versus methylphenidate, but can't see any obvious way to extract these data. I'm interested to know because I think that the results may have implications for the sustainability of therapeutic benefits with these agents. Thanks,

I think amphetamine results in greater and more sustained DA release as it releases DA from both storage vesicles and newly synthesized DA in the cytosol. Methylphenidate releases from vesicles only.


- Scott

 

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poster:SLS thread:686123
URL: http://www.dr-bob.org/babble/20060909/msgs/686140.html