Shown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by JaclinHyde on May 20, 2006, at 17:38:10
You can learn a lot from reading this paper on MAOI's.
http://www.acnp.org/G4/GN401000046/CH046.html
Lot's of good info here.
JH
Posted by RobertDavid on May 20, 2006, at 19:52:10
In reply to A great read re: MAOI's, posted by JaclinHyde on May 20, 2006, at 17:38:10
> You can learn a lot from reading this paper on MAOI's.
>
> http://www.acnp.org/G4/GN401000046/CH046.html
>
> Lot's of good info here.
>
> JH
Now that's a ton of info on MAOI's. Great post!
Posted by UgottaHaveHOPE on May 20, 2006, at 20:26:52
In reply to Re: A great read re: MAOI's, posted by RobertDavid on May 20, 2006, at 19:52:10
I went to college, but I cant understand all that medical jargon. I wish there were articles in laymen's terms.
Posted by willyee on May 20, 2006, at 21:19:32
In reply to Re: You guys must be MDs, posted by UgottaHaveHOPE on May 20, 2006, at 20:26:52
Not even so much i cant understand it,as much as its so much to take in,i dont have the mental energy for it,i know that sounds bad,but im looking at it wishinh there were cliff notes cause it does look like info i wanna know,i see serotion syndrome info and tca/ssri/moai combo info etc,but again the best im able to do is breeze through it.STINKS DONT IT!
Posted by Phillipa on May 20, 2006, at 21:40:45
In reply to Re: You guys must be MDs, posted by willyee on May 20, 2006, at 21:19:32
Yes we need it explained in layman's terms can either of you do that or are you just posting articles you know we won't understand. Love Phillipa
Posted by heaven help me on May 20, 2006, at 22:17:03
In reply to Re: You guys must be MDs, posted by Phillipa on May 20, 2006, at 21:40:45
I'm Super Layman (woman) when it comes to many of the posts on this sight. Is there any sight or list where I can go to even get a translations of all the acronyms used on this board? I have a hard time reading a lot of them.
Thanks
Mary
Posted by linkadge on May 20, 2006, at 23:12:38
In reply to A great read re: MAOI's, posted by JaclinHyde on May 20, 2006, at 17:38:10
I like the summary of the effects of the MAOI's on sleep archetecture. Of all the antidepressants, the MAOI's seem to supress REM sleep the most. They are also, arguably, the most effective. I don't think there is a conincidence.
Linkadge
Posted by Phillipa on May 21, 2006, at 0:12:02
In reply to Re: A great read re: MAOI's, posted by linkadge on May 20, 2006, at 23:12:38
Link you like and think the MAOI's work? Love Phillipa
Posted by Jost on May 21, 2006, at 14:40:44
In reply to Re: A great read re: MAOI's, posted by linkadge on May 20, 2006, at 23:12:38
I read that, about their strongly suppressing dreaming also--which is one reason I was very unhappy about trying parnate, initially. As I wrote above, it didn't work that way for me---
I don't really believe the dream-suppression/AD effect connection-- and I think dreams are really important...
Jost
Posted by linkadge on May 21, 2006, at 15:29:30
In reply to Re: A great read re: MAOI's » linkadge, posted by Phillipa on May 21, 2006, at 0:12:02
They are effective meds for a lot of people.
Linkadge
Posted by linkadge on May 21, 2006, at 15:35:30
In reply to Re: A great read re: MAOI's, posted by Jost on May 21, 2006, at 14:40:44
>I don't really believe the dream-suppression/AD >effect connection
I don't know if dreaming is restricted to just REM sleep, I could be wrong.
Before the monoamine hypothesis REM sleep hypothesis was very strong. Pretty much all effective antidepressants supress REM sleep. Infact, if you take an extremely depressed individual, connect them up to a eye scanner, and wake them up whenever they start to enter REM, they will likely wake up very chipper the next morning.
In addition, if you take enough of an agent that counteracts the drug induced REM supression, (often cholinergics), you can often completely abolish any antidepressant effect.
I think thats all our current antidepressants are, is a bunch of REM supressing agents.
Linkadge
Posted by Dr. Bob on May 21, 2006, at 15:53:40
In reply to from Super Layman...., posted by heaven help me on May 20, 2006, at 22:17:03
> I'm Super Layman (woman) when it comes to many of the posts on this sight. Is there any sight or list where I can go to even get a translations of all the acronyms used on this board? I have a hard time reading a lot of them.
Here's one list:
http://health.groups.yahoo.com/group/psycho-babble-tips/links/Miscellaneous_001009377572
Hope that helps!
Bob
Posted by heaven help me on May 21, 2006, at 16:27:30
In reply to Re: acronyms, posted by Dr. Bob on May 21, 2006, at 15:53:40
nm
Posted by RobertDavid on May 21, 2006, at 17:16:43
In reply to Re: A great read re: MAOI's, posted by Jost on May 21, 2006, at 14:40:44
> I read that, about their strongly suppressing dreaming also--which is one reason I was very unhappy about trying parnate, initially. As I wrote above, it didn't work that way for me---
>
> I don't really believe the dream-suppression/AD effect connection-- and I think dreams are really important...
>
> Jost
For some reason I dream much more than I used to before trying EMSAM. A considerable increase, go figure.
Posted by Jost on May 21, 2006, at 19:40:13
In reply to Re: A great read re: MAOI's, posted by RobertDavid on May 21, 2006, at 17:16:43
I like maois-- and it's possible the REM hypothesis is true. I've also heard some skepticism about it. Since the function of dreaming isn't understood-- it's hard to say.
There's some thought that you dream for much greater periods of the night, but that REM dreams are much more emotionally and visually charged than other dreams. Non-REM dreams also seem closer to thinking than what we usually consider dreams.
Jost
Posted by linkadge on May 21, 2006, at 22:05:26
In reply to Re: A great read re: MAOI's, posted by Jost on May 21, 2006, at 19:40:13
EMSAM might affect REM sleep in a manner more like Wellbutrin. I think the MAO-A inhibition is needed for the REM suppressant effects.
I think that REM sleep tries to ballance the noradrenergic/cholinergic systems. If REM is not working properly, or is increased (such as in some depression), perhaps there is a cholinergic dominance and hence depression.
The funny thing is that REM sleep supression itself increases serotonin in the hippocampus
REM supression also decreases the beta-adrenergic and 5-ht2 systems as is seen with antidepressant treatment.Interestingly enough, rats that undergo REM deprivation also show increased sensitivity of d2 receptors, as is often seen with effective antidepressant treatment.
Linkadge
Posted by Jost on May 22, 2006, at 20:45:06
In reply to Re: A great read re: MAOI's, posted by linkadge on May 21, 2006, at 22:05:26
> EMSAM might affect REM sleep in a manner more like Wellbutrin. I think the MAO-A inhibition is needed for the REM suppressant effects.
>
> I think that REM sleep tries to ballance the noradrenergic/cholinergic systems. If REM is not working properly, or is increased (such as in some depression), perhaps there is a cholinergic dominance and hence depression.
>
> The funny thing is that REM sleep supression itself increases serotonin in the hippocampus
> REM supression also decreases the beta-adrenergic and 5-ht2 systems as is seen with antidepressant treatment.
>
> Interestingly enough, rats that undergo REM deprivation also show increased sensitivity of d2 receptors, as is often seen with effective antidepressant treatment.
>
> LinkadgeThat's interesting, Linkadge. Any references for it? I'm interesting in the phenomenon of dreams.
Thanks, Jost
Posted by Jost on May 22, 2006, at 20:45:44
In reply to Re: A great read re: MAOI's--linkadge, posted by Jost on May 22, 2006, at 20:45:06
I meant "interested" === Jost
This is the end of the thread.
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