![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Kristopher on May 2, 2006, at 21:29:29
Does anyone know if EMSAM affects serotonin at the 6mg dosage? I can't seem to find any information about this. I know it's an MAO-B medicine, and MAO-A is what affects serotonin. Would a higher dosage of EMSAM be more affective?
thanks
Kris
Posted by Pfinstegg on May 2, 2006, at 22:25:14
In reply to EMSAM and serotonin, posted by Kristopher on May 2, 2006, at 21:29:29
The PDR info lists EMSAM as inhibiting both MAO A and B, at all dosages, although with a greater affinity for MAO B. These are enzymes on the outer membranes of cellular mitochondria. Inhibiting them allows for greater activity of all three neurotransmitter monoamines: nor-epinephrine, dopamine and serotonin. I think that serotonin is relatively less influenced than the other two monoamines, but all are influenced. I don't know, but I wonder if this is why the oral MAOI's tend to remain effective and helpful for some people for many years- the neurotransmitters' activity is enhanced, but they remain in greater balance with one another.
Posted by Phillipa on May 2, 2006, at 22:28:17
In reply to Re: EMSAM and serotonin » Kristopher, posted by Pfinstegg on May 2, 2006, at 22:25:14
I keep praying people will have good reactions to ENSAM I will take money out of my money market if it works. Love Phillipa
Posted by Kristopher on May 2, 2006, at 22:40:48
In reply to Re: EMSAM and serotonin » Kristopher, posted by Pfinstegg on May 2, 2006, at 22:25:14
Thank you Pfinstegg.
> The PDR info lists EMSAM as inhibiting both MAO A and B, at all dosages, although with a greater affinity for MAO B. These are enzymes on the outer membranes of cellular mitochondria. Inhibiting them allows for greater activity of all three neurotransmitter monoamines: nor-epinephrine, dopamine and serotonin. I think that serotonin is relatively less influenced than the other two monoamines, but all are influenced. I don't know, but I wonder if this is why the oral MAOI's tend to remain effective and helpful for some people for many years- the neurotransmitters' activity is enhanced, but they remain in greater balance with one another.
Posted by Donna Louise on May 4, 2006, at 7:51:04
In reply to EMSAM and serotonin, posted by Kristopher on May 2, 2006, at 21:29:29
> Does anyone know if EMSAM affects serotonin at the 6mg dosage? I can't seem to find any information about this. I know it's an MAO-B medicine, and MAO-A is what affects serotonin. Would a higher dosage of EMSAM be more affective?
>
> thanks
>
> KrisThe way they have this labeled or whatever is what is misleading and confusing. It is acutally a 20mg dose when they say 6mg (why why why, someont tell me I don't understand that) so since it is 20 mg it is non selective and does deanimate MAO A allowing more seratonin in the system. This is why I worry about taking the 5 HTP your doc suggested. I have not heard back from anyone saying that it makes them as apprehensive as it does me but I don't trust any pdocs, any docs for that matter, I have to do my own research before I will listen to what they say is ok.
Donna
Posted by Kristopher on May 4, 2006, at 16:19:35
In reply to Re: EMSAM and serotonin » Kristopher, posted by Donna Louise on May 4, 2006, at 7:51:04
I'm doing great on EMSAM. A day or so ago it really seemed to kick in. I'm not taking the 5-htp. I decided against that. Thank you Donna Louise!
I'll post soon, but so far so good. The anxiety is much less this week, and I think the serotonin effect of the selegiline took effect -- finally!
kris
Posted by RobertDavid on May 4, 2006, at 18:34:32
In reply to Re: EMSAM and serotonin, posted by Kristopher on May 4, 2006, at 16:19:35
Glad to hear it's starting to work for you. It's changed my life for sure. I'm 28 days on it now and if you're like me it will continue to improve. I was begining to doubt that and anti depressant would work for me. Best of luck! Rob
Posted by jealibeanz on May 4, 2006, at 21:03:50
In reply to Re: EMSAM and serotonin, posted by Kristopher on May 4, 2006, at 16:19:35
Could the serotonin lead to weight gain, like SSRI'sm Buspar, and Effexor have with me? I even gained with the weak reuptake of serotonin in Wellbutrin!
Posted by Donna Louise on May 4, 2006, at 23:22:23
In reply to Re: EMSAM and serotonin, posted by Kristopher on May 4, 2006, at 16:19:35
> I'm doing great on EMSAM. A day or so ago it really seemed to kick in. I'm not taking the 5-htp. I decided against that. Thank you Donna Louise!
>
> I'll post soon, but so far so good. The anxiety is much less this week, and I think the serotonin effect of the selegiline took effect -- finally!
>
> krisI am so relieved to hear this, I can now cross you off my list of things to worry about :-))
Donna
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.