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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by summerflowers on February 21, 2006, at 17:19:00
Has anyone heard of tardia psychosis?Iv just heard the devestating news of what my husband has.If anyone has it or had it or knows anything about it,please help.Is it permanant?Iv heard it is.What helps or cures it?Anyone?
Posted by Racer on February 21, 2006, at 19:46:31
In reply to Tardia psychosis, posted by summerflowers on February 21, 2006, at 17:19:00
I just did a quick google, and found it described as "supersensitivity psychosis" and "neuroleptic withdrawal psychosis." Says that it's psychosis caused by withdrawal of medications. That's all I know, but I would think that the last name in there implies that he'll get past it once he's past the withdrawal.
Again, that's only a quick google, and I don't have time to read all the hits, so don't take it as knowledge.
Posted by mattw84 on February 21, 2006, at 20:06:22
In reply to Re: Tardia psychosis, posted by Racer on February 21, 2006, at 19:46:31
I believe it is "Tardive Psychosis," and I am suprised to hear that it is an official diagnosis. Not that I don't believe it, just basically a medical myth that can be explained by other means.
The theory is that it is caused by long-term treatment with neuroleptics (Lithium, etc). I believe this is also called "Malignant Neuroleptic Syndrome," don't quote me on it though. Regarding the effects it has on CK, creatine, blood levels which mess up dopamine activity (via inositol[sp??] and adenosin [sp??]). I think the syndrome is more common to overdose victims but can affect long-term users as well, just more slowly.
Either way it doesn't sound pleasant, hope things get better. Regards,
Matt
Posted by Phillipa on February 21, 2006, at 20:33:15
In reply to Re: Tardia psychosis, posted by mattw84 on February 21, 2006, at 20:06:22
Think I'll google this one too. Fondly, Phillipa
Posted by Phillipa on February 21, 2006, at 20:40:04
In reply to Re: Tardia psychosis, posted by Phillipa on February 21, 2006, at 20:33:15
Here's my google search. Fondly, Phillipahttp://www.namiscc.org/newsletters/Sept01/discontinuation.htm
Posted by summerflowers on February 22, 2006, at 2:05:22
In reply to Re: Tardia psychosis, posted by Phillipa on February 21, 2006, at 20:40:04
>
> Here's my google search. Fondly, Phillipa
>
>
>
> http://www.namiscc.org/newsletters/Sept01/discontinuation.htmThanks I did a search myself(up all night and didnt sleep a wink),but all I could find was bits and pieces.My head is hurting and im just so worked up.
Posted by Larry Hoover on February 22, 2006, at 11:38:19
In reply to Tardia psychosis, posted by summerflowers on February 21, 2006, at 17:19:00
> Has anyone heard of tardia psychosis?Iv just heard the devestating news of what my husband has.If anyone has it or had it or knows anything about it,please help.Is it permanant?Iv heard it is.What helps or cures it?Anyone?
I think that you'll find much more information if you use the newer terminology for this syndrome. After around 1990, the literature refers to it as supersensitivity psychosis (SSP).
The treatment choices usually are anti-epileptic drugs, as far as I can surmise. http://www.namiscc.org/newsletters/April02/SupersensitivityPsychosis.htm
Another option is atypical antipsychotic therapy, e.g. risperidone (Risperdal).
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7531355It is probably permanent, in that it arises from long term treatment with conventional antipsychotics (e.g. haloperidol/Haldol). That said, it also appears to be treatable, by switching to newer medication.
I was unable to find a concensus treatment. You're probably going to have to do a little experimentation with other drugs.
Best of luck with everything,
Lar
Posted by med_empowered on February 22, 2006, at 14:35:51
In reply to Re: Tardia psychosis » summerflowers, posted by Larry Hoover on February 22, 2006, at 11:38:19
hey! My understanding of tardive psychosis is this: neuroleptics work by blocking D2 receptors (in order to be effective, you need something like a 70% blockade). The body compensates by sprouting new D2 receptors--sometimes up to 50% more than normal. When the drug is withdrawn, the brain is sensitive to psychosis; hence, supersensitivity psychosis.
Anti-epilepsy drugs (depakote, trileptal, etc.) may help by reducing/treating the "kindling". You may also need a neuroleptic, ideally one that won't make the situation worse--some antipsychotics (moban, abilify) seem to cause little or no supersensitivity, compared to other available drugs.
Posted by summerflowers on February 23, 2006, at 3:09:47
In reply to Re: Tardia psychosis, posted by med_empowered on February 22, 2006, at 14:35:51
> hey! My understanding of tardive psychosis is this: neuroleptics work by blocking D2 receptors (in order to be effective, you need something like a 70% blockade). The body compensates by sprouting new D2 receptors--sometimes up to 50% more than normal. When the drug is withdrawn, the brain is sensitive to psychosis; hence, supersensitivity psychosis.
>
> Anti-epilepsy drugs (depakote, trileptal, etc.) may help by reducing/treating the "kindling". You may also need a neuroleptic, ideally one that won't make the situation worse--some antipsychotics (moban, abilify) seem to cause little or no supersensitivity, compared to other available drugs.> Thanks guys.I cried and cried because when I first looked up Tardive psychosis it said something like it is permanant insanity caused by neuroleptics,and he never heard voices or anything before he went on them and I was so ANGRY,and so sad for him,and I saw no hope at all.Id also found out he had (sp)neuroleptic malignant syndrome,once in hospital when they had his doses too high and then at home he had the exact symptoms which is why the meds were stopped so drastically.And why the doc doesnt want to give him anything much because in hospital he had an abnormal ECG.I dont know why he was overmedicated,prob because hes a nutter,In hospital he would basically try to break every window to get out,but hes never hit a person?ANYWAY,I now have HOPE because from what iv been studying and learnt,firstly:fish oil and niacin,which I got him today,second socialization.His whole social network was broken down and trust in people so he needs to feel safe again.I find the whole issue of dopamine,receptors and how they compensate and all of that really intruiging,and the more iv been thinking about it the more theories come to me,especially when im out and about and thinking about all the other people out there too.Im going to learn more.Only one thing I dont get,if more receptors are made,then when the neuroleptics are stopped, and the person is getting too much dopamine,does the brain readjust itself again and lose those access receptors if its left to it?naturally
Posted by MoparFan91 on February 23, 2006, at 3:37:01
In reply to Re: Tardia psychosis, posted by summerflowers on February 23, 2006, at 3:09:47
Posted by med_empowered on February 23, 2006, at 9:02:59
In reply to Re: Tardia psychosis, posted by summerflowers on February 23, 2006, at 3:09:47
hi! the brain might re-adjust--most people recommend gradually withdrawing the drugs, so the brain can adjust...sudden withdrawal is not a good idea.
I'm really sorry about all this. I hope he gets better.
Posted by summerflowers on February 23, 2006, at 16:19:38
In reply to Re: Tardia psychosis, posted by med_empowered on February 23, 2006, at 9:02:59
Thankyou.I have hope he will get better. im going to learn everything I can.
This is the end of the thread.
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