Posted by med_empowered on February 22, 2006, at 14:35:51
In reply to Re: Tardia psychosis » summerflowers, posted by Larry Hoover on February 22, 2006, at 11:38:19
hey! My understanding of tardive psychosis is this: neuroleptics work by blocking D2 receptors (in order to be effective, you need something like a 70% blockade). The body compensates by sprouting new D2 receptors--sometimes up to 50% more than normal. When the drug is withdrawn, the brain is sensitive to psychosis; hence, supersensitivity psychosis.
Anti-epilepsy drugs (depakote, trileptal, etc.) may help by reducing/treating the "kindling". You may also need a neuroleptic, ideally one that won't make the situation worse--some antipsychotics (moban, abilify) seem to cause little or no supersensitivity, compared to other available drugs.
poster:med_empowered
thread:611815
URL: http://www.dr-bob.org/babble/20060219/msgs/612103.html