Posted by summerflowers on February 23, 2006, at 3:09:47
In reply to Re: Tardia psychosis, posted by med_empowered on February 22, 2006, at 14:35:51
> hey! My understanding of tardive psychosis is this: neuroleptics work by blocking D2 receptors (in order to be effective, you need something like a 70% blockade). The body compensates by sprouting new D2 receptors--sometimes up to 50% more than normal. When the drug is withdrawn, the brain is sensitive to psychosis; hence, supersensitivity psychosis.
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> Anti-epilepsy drugs (depakote, trileptal, etc.) may help by reducing/treating the "kindling". You may also need a neuroleptic, ideally one that won't make the situation worse--some antipsychotics (moban, abilify) seem to cause little or no supersensitivity, compared to other available drugs.> Thanks guys.I cried and cried because when I first looked up Tardive psychosis it said something like it is permanant insanity caused by neuroleptics,and he never heard voices or anything before he went on them and I was so ANGRY,and so sad for him,and I saw no hope at all.Id also found out he had (sp)neuroleptic malignant syndrome,once in hospital when they had his doses too high and then at home he had the exact symptoms which is why the meds were stopped so drastically.And why the doc doesnt want to give him anything much because in hospital he had an abnormal ECG.I dont know why he was overmedicated,prob because hes a nutter,In hospital he would basically try to break every window to get out,but hes never hit a person?ANYWAY,I now have HOPE because from what iv been studying and learnt,firstly:fish oil and niacin,which I got him today,second socialization.His whole social network was broken down and trust in people so he needs to feel safe again.I find the whole issue of dopamine,receptors and how they compensate and all of that really intruiging,and the more iv been thinking about it the more theories come to me,especially when im out and about and thinking about all the other people out there too.Im going to learn more.Only one thing I dont get,if more receptors are made,then when the neuroleptics are stopped, and the person is getting too much dopamine,does the brain readjust itself again and lose those access receptors if its left to it?naturally
poster:summerflowers
thread:611815
URL: http://www.dr-bob.org/babble/20060219/msgs/612349.html