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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by cache-monkey on January 7, 2006, at 14:00:11
Dear all,
I started selegiline at a very low-dose (2.5 mg) about four weeks ago. I take my dose when I wake up and have noticed this odd pattern. I tend to get sleepy after taking selegiline and this peaks about 5 hours later, after which I become progressively more and more alert.
I'm a little perplexed. I wonder if this means that the pro-dopamine effect is actually relaxing for me, but then eventually the norepinephrinetic effects of the metabolites kick in the counterbalance this. I've read some posts by KaraS indicating a similar pattern of response, but has anyone else had an experience like this?
Also, I'm thinking about moving the dose to bedtime. I suppose the only way to know if this is helpful is to try it, but has anyone tried late-day dosing of selegiline? If so, how did this affect your sleep?
Thanks for the input.
Best,
cache-monkey
Posted by cache-monkey on January 7, 2006, at 14:13:49
In reply to Selegiline- sleepy then wide awake (KaraS,others?), posted by cache-monkey on January 7, 2006, at 14:00:11
I forgot to mention that the late-day alertness from early-day selegiline dosing is actually causing some insomnia right now...
~cache-monkey
Posted by utopizen on January 7, 2006, at 16:31:51
In reply to PS: Selegiline- sleepy then wide awake, posted by cache-monkey on January 7, 2006, at 14:13:49
> I forgot to mention that the late-day alertness from early-day selegiline dosing is actually causing some insomnia right now...
>
> ~cache-monkeyjust take it at bedtime, just like any drug, when u are initially tired immediately after taking it for a few hours.
I think you're over-thinking this a bit... I took this at 10mg/day, no problems, it actually made me not tired at all-- mostly, from it letting me crawl out of an extremely deep depression, augmented with 45mg of Lexapro.
I now just take Lexapro, 45mg/day, but took Selegiline after Lexapro wasn't doing anything for me for 3 months.
I took the Selegiline for 6 months straight, combined with PLPA, at 1500mg. PLPA is found in foods, and is synergistic to the Selegiline.
Anyhow, if it's still a problem, which I doubt it will be once you take it at night, take some Provigil to augment with it.
Docs prescribe Provigil all the time for drugs that cause somnolence, mostly because most drugs only cause somnolence while your body first adjusts to it.
But I don't think that matters for you, since you say it's only making you sleepy for a few hours. This happens with many, many meds, and no, no one knows why this happens.
Also, any drug hits so many different sites of your brain, please don't worry about where and why your brain regions are being effected.
If it were true, then everyone would get the same result. Unfortunately, it's likely a combination of many, many, many different brain regions, you, your DNA, your expectation of drug effect, your sleeping habits, and your time of ingestion during the day.
take it at night, and it's all good.
Posted by Declan on January 7, 2006, at 16:38:41
In reply to Selegiline- sleepy then wide awake (KaraS,others?), posted by cache-monkey on January 7, 2006, at 14:00:11
About 10 years ago I took 2.5mg/d selegeline for ages and, in retrospect, I can see that it made sleep less deep. Then even 1mg/d liquid deprenyl did the same. I now take some mucana in the morning instead and sleep is deeper.
I wonder if less good deep sleep at night leads you to have daytime tiredness?? Could it just be that, do you think?
I have never noticed an immediate effect from deprenyl or selegeline. Somewhere I read about patients being treated for depression with selegeline waking up in the early morning, but that would have been on AD doses, and from the l-amphetamine metabolite.
Declan
This is the end of the thread.
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