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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by iforgotmypassword on December 5, 2005, at 9:38:53
i think i know of these:
alpha-1 adrenoreceptor
alpha-2 adrenoreceptor (2A and 2B?)
beta-1 adrenoreceptor
beta-2 adrenoreceptor
D4 receptornow what i'm wondering is:
1. Are there other receptors?
2. Are there other agonizing chemicals that act at certain sorts of NE receptors? Are they as potent as agonists? Are there any endogeneous antagonists?
3. What are the specific actions of each? And where in the brain do they reside? How do they relate to the function of other receptors?
4. If you block a beta adrenoreceptor, does this lead to stimulation of the alpha adrenoreceptors?
5. Is beta receptor stimulation the sole basis for how NE increase can cause hypertensive effects?
6. Which NE actions are specifically not known for AD-like effects but may help cognition?
7. Is a real function of NE to single out acetylcholine being a catecholamine?Sorry, this is lots, but any input would be interesting...
Posted by blueberry on December 6, 2005, at 5:08:37
In reply to what are the receptors, neurological actions of NE, posted by iforgotmypassword on December 5, 2005, at 9:38:53
Excellent questions. Unfortunately I have no answers. I too am interested in the things you ask about. In particular, I respond poorly to anything that increases norepinephrine function, so I want to know how to squash norepinephrine...I want less of it, not more.
I do know from experience that if I block an a-2 receptor, it stimulates norepinephrine release. But for me, that means a worse mood and increased tinnitus.
I know from my own experience that if I help an a-1 receptor (by adrafinil or modafinil, both a-1 agonists) it produces an antidepressant response and a cognitive enhancing response.
> i think i know of these:
> alpha-1 adrenoreceptor
> alpha-2 adrenoreceptor (2A and 2B?)
> beta-1 adrenoreceptor
> beta-2 adrenoreceptor
> D4 receptor
>
> now what i'm wondering is:
> 1. Are there other receptors?
> 2. Are there other agonizing chemicals that act at certain sorts of NE receptors? Are they as potent as agonists? Are there any endogeneous antagonists?
> 3. What are the specific actions of each? And where in the brain do they reside? How do they relate to the function of other receptors?
> 4. If you block a beta adrenoreceptor, does this lead to stimulation of the alpha adrenoreceptors?
> 5. Is beta receptor stimulation the sole basis for how NE increase can cause hypertensive effects?
> 6. Which NE actions are specifically not known for AD-like effects but may help cognition?
> 7. Is a real function of NE to single out acetylcholine being a catecholamine?
>
> Sorry, this is lots, but any input would be interesting...
Posted by Larry Hoover on December 6, 2005, at 10:24:48
In reply to what are the receptors, neurological actions of NE, posted by iforgotmypassword on December 5, 2005, at 9:38:53
> i think i know of these:
> alpha-1 adrenoreceptor
> alpha-2 adrenoreceptor (2A and 2B?)
> beta-1 adrenoreceptor
> beta-2 adrenoreceptor
> D4 receptorMore. Go to: http://kidb.cwru.edu/pdsp.php
Plug in norepinephrine in the "test ligand" box, in the left query table. Hit "submit"
> now what i'm wondering is:
> 1. Are there other receptors?See above.
> 2. Are there other agonizing chemicals that act at certain sorts of NE receptors? Are they as potent as agonists?
Your questions read in a confusing way.
Go to that same database. Leaving all other fields blank, enter a receptor type in the receptor name field. Or, in this case, it may be simpler to select from the pull-down list in the right query table.
This database gives you binding affinities, but does not give (ant)agonism data. The right hand field of the response table is hotlinks to Pubmed. You may find your answer there.
> Are there any endogeneous antagonists?
I am certain there are endogenous modulators of the NE receptors. I would be amazed if there were not. However, I don't know an explicit answer for you.
> 3. What are the specific actions of each? And where in the brain do they reside? How do they relate to the function of other receptors?
I think you may have to ask God that.
> 4. If you block a beta adrenoreceptor, does this lead to stimulation of the alpha adrenoreceptors?
> 5. Is beta receptor stimulation the sole basis for how NE increase can cause hypertensive effects?
> 6. Which NE actions are specifically not known for AD-like effects but may help cognition?
> 7. Is a real function of NE to single out acetylcholine being a catecholamine?Apart from my uncertainty about what you're asking in question 7, I don't know.
You could google for the answer to 5, for example. Quotation marks, and keyword selection, are the essential skills to learn. "beta-adrenoceptor stimulation" as an example, forces Google to treat that as a string, which returns only sites where that exact quotation appears. Play with it. Google totally rocks.
> Sorry, this is lots, but any input would be interesting...Good luck. And let us know if you find some answers.
Lar
Posted by chemist on December 6, 2005, at 12:06:54
In reply to what are the receptors, neurological actions of NE, posted by iforgotmypassword on December 5, 2005, at 9:38:53
hello there, chemist here...as far as #7, below, is concerned: acetylcholine is not a catecholamine nor a catechol; NE is a catecholamine...the receptor specificity for ACh as a substrate is quite high and thus AChE is targeted. NE has many important roles - one of them is as an endogenous precursor to epinephrine - but classifying ACh is not at the top of the list...all the best, chemist
> 7. Is a real function of NE to single out acetylcholine being a catecholamine?
Posted by iforgotmypassword on December 7, 2005, at 3:26:01
In reply to Re: what are the receptors, neurological actions o » iforgotmypassword, posted by chemist on December 6, 2005, at 12:06:54
yeah, i meant NE being a catecholamine... sorry, i suck when it comes to grammar. i seem to remember hearing of there being a balance or competition between ACh and catecholamines, especially with regards to ADs. does it explain some dry mouth people occassionally get on MAOIs as they are not directly anticholinergic?
Posted by chemist on December 8, 2005, at 19:05:59
In reply to Re: what are the receptors, neurological actions o » chemist, posted by iforgotmypassword on December 7, 2005, at 3:26:01
> yeah, i meant NE being a catecholamine... sorry, i suck when it comes to grammar. i seem to remember hearing of there being a balance or competition between ACh and catecholamines, especially with regards to ADs. does it explain some dry mouth people occassionally get on MAOIs as they are not directly anticholinergic?
hello there, chemist here...there is a proposed ``up and down'' for NE and ACh, respectively...if NE is up, mania...if ACh is up, depression...perhaps the muscarinic receptors - affinity for ACh - are to blame for the dry mouth...the nicotinic receptors are, in my opinion, less likely a culprit...and any number of 5-HT receptors can contribute to side effects such as dry mouth...the noradrenergic/cholinergic balance hypothesis includes a role for dopamine, too, and i believe there were experiments conducted in this light...in the end, i apologize for the non-response and encourage you to look up publications by Janowsky circa 1970...all the best, chemist
Posted by iforgotmypassword on December 9, 2005, at 8:21:41
In reply to Re: what are the receptors, neurological actions o » iforgotmypassword, posted by chemist on December 8, 2005, at 19:05:59
This is the end of the thread.
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