Posted by Larry Hoover on December 6, 2005, at 10:24:48
In reply to what are the receptors, neurological actions of NE, posted by iforgotmypassword on December 5, 2005, at 9:38:53
> i think i know of these:
> alpha-1 adrenoreceptor
> alpha-2 adrenoreceptor (2A and 2B?)
> beta-1 adrenoreceptor
> beta-2 adrenoreceptor
> D4 receptorMore. Go to: http://kidb.cwru.edu/pdsp.php
Plug in norepinephrine in the "test ligand" box, in the left query table. Hit "submit"
> now what i'm wondering is:
> 1. Are there other receptors?See above.
> 2. Are there other agonizing chemicals that act at certain sorts of NE receptors? Are they as potent as agonists?
Your questions read in a confusing way.
Go to that same database. Leaving all other fields blank, enter a receptor type in the receptor name field. Or, in this case, it may be simpler to select from the pull-down list in the right query table.
This database gives you binding affinities, but does not give (ant)agonism data. The right hand field of the response table is hotlinks to Pubmed. You may find your answer there.
> Are there any endogeneous antagonists?
I am certain there are endogenous modulators of the NE receptors. I would be amazed if there were not. However, I don't know an explicit answer for you.
> 3. What are the specific actions of each? And where in the brain do they reside? How do they relate to the function of other receptors?
I think you may have to ask God that.
> 4. If you block a beta adrenoreceptor, does this lead to stimulation of the alpha adrenoreceptors?
> 5. Is beta receptor stimulation the sole basis for how NE increase can cause hypertensive effects?
> 6. Which NE actions are specifically not known for AD-like effects but may help cognition?
> 7. Is a real function of NE to single out acetylcholine being a catecholamine?Apart from my uncertainty about what you're asking in question 7, I don't know.
You could google for the answer to 5, for example. Quotation marks, and keyword selection, are the essential skills to learn. "beta-adrenoceptor stimulation" as an example, forces Google to treat that as a string, which returns only sites where that exact quotation appears. Play with it. Google totally rocks.
> Sorry, this is lots, but any input would be interesting...Good luck. And let us know if you find some answers.
Lar
poster:Larry Hoover
thread:585697
URL: http://www.dr-bob.org/babble/20051203/msgs/586066.html