Posted by blueberry on December 6, 2005, at 5:08:37
In reply to what are the receptors, neurological actions of NE, posted by iforgotmypassword on December 5, 2005, at 9:38:53
Excellent questions. Unfortunately I have no answers. I too am interested in the things you ask about. In particular, I respond poorly to anything that increases norepinephrine function, so I want to know how to squash norepinephrine...I want less of it, not more.
I do know from experience that if I block an a-2 receptor, it stimulates norepinephrine release. But for me, that means a worse mood and increased tinnitus.
I know from my own experience that if I help an a-1 receptor (by adrafinil or modafinil, both a-1 agonists) it produces an antidepressant response and a cognitive enhancing response.
> i think i know of these:
> alpha-1 adrenoreceptor
> alpha-2 adrenoreceptor (2A and 2B?)
> beta-1 adrenoreceptor
> beta-2 adrenoreceptor
> D4 receptor
>
> now what i'm wondering is:
> 1. Are there other receptors?
> 2. Are there other agonizing chemicals that act at certain sorts of NE receptors? Are they as potent as agonists? Are there any endogeneous antagonists?
> 3. What are the specific actions of each? And where in the brain do they reside? How do they relate to the function of other receptors?
> 4. If you block a beta adrenoreceptor, does this lead to stimulation of the alpha adrenoreceptors?
> 5. Is beta receptor stimulation the sole basis for how NE increase can cause hypertensive effects?
> 6. Which NE actions are specifically not known for AD-like effects but may help cognition?
> 7. Is a real function of NE to single out acetylcholine being a catecholamine?
>
> Sorry, this is lots, but any input would be interesting...
poster:blueberry
thread:585697
URL: http://www.dr-bob.org/babble/20051203/msgs/586008.html