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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by ghost on December 26, 2004, at 14:13:29
anyone know anything about it? i'm googling the wrong things, apparently, because i keep getting weird spam sites.
my mom sent me a box of florida oranges, grapefruits, and a lime, and i'm wondering what i have to worry about since the bottle says to avoid grapefruit and grapefruit juice while taking it.
any help is appreciated!
ghost
Posted by tensor on December 26, 2004, at 14:37:47
In reply to grapefruit (fruit and juice) and xanax interaction, posted by ghost on December 26, 2004, at 14:13:29
Hi,
never heard of. You shouldn't drink alcohol either while taking benzos, but i have no problem taking a glass of wine or two.
Check out:
http://www.rxlist.com/cgi/generic/alpraz_ad.htm
Posted by jujube on December 26, 2004, at 14:43:22
In reply to grapefruit (fruit and juice) and xanax interaction, posted by ghost on December 26, 2004, at 14:13:29
On the Drug Fact Sheet (quite lengthy) I got when I had my prescription re-filled, it too says to avoid eating or drinking grapefruit juice while taking Xanax. It goes on to say that grapefruit juice can increase the amount of certain medications in the bloodstream. It doesn't appear to be prohibited, but I suppose you just need to be careful to ensure you don't end up over-sedated. I think the orange juice should be ok. I drink a lot of oj and take 2,000 mg - 3,000 mg of vitamin C, and I have never had a problem taking any medication, including Xanax.
Tamara
> anyone know anything about it? i'm googling the wrong things, apparently, because i keep getting weird spam sites.
>
> my mom sent me a box of florida oranges, grapefruits, and a lime, and i'm wondering what i have to worry about since the bottle says to avoid grapefruit and grapefruit juice while taking it.
>
> any help is appreciated!
>
>
> ghost
Posted by jujube on December 26, 2004, at 14:57:58
In reply to grapefruit (fruit and juice) and xanax interaction, posted by ghost on December 26, 2004, at 14:13:29
Here are a couple of websites that address the issue
http://www.mtic.com/Cytochromes/GFJ.HTML
http://www.powernetdesign.com/grapefruit/references
> anyone know anything about it? i'm googling the wrong things, apparently, because i keep getting weird spam sites.
>
> my mom sent me a box of florida oranges, grapefruits, and a lime, and i'm wondering what i have to worry about since the bottle says to avoid grapefruit and grapefruit juice while taking it.
>
> any help is appreciated!
>
>
> ghost
Posted by jujube on December 26, 2004, at 15:03:18
In reply to Re: grapefruit (fruit and juice) and xanax interaction » ghost, posted by jujube on December 26, 2004, at 14:57:58
The first website is actually
Posted by Larry Hoover on December 26, 2004, at 15:38:09
In reply to grapefruit (fruit and juice) and xanax interaction, posted by ghost on December 26, 2004, at 14:13:29
> anyone know anything about it? i'm googling the wrong things, apparently, because i keep getting weird spam sites.
>
> my mom sent me a box of florida oranges, grapefruits, and a lime, and i'm wondering what i have to worry about since the bottle says to avoid grapefruit and grapefruit juice while taking it.
>
> any help is appreciated!
>
>
> ghostAlprazolam is metabolized by the enzyme 3A4. Grapefruit and its juice inhibit that enzyme. If that enzyme is inhibited while you have alprazolam in your system, it will remain more active than it otherwise would have. That is to say, its half-life will be extended. If you take the grapefruit before the alprazolam, you will have an additional effect, as 3A4 also exists in the intestinal wall. You will have an effect as if you took more alprazolam than you actually did, and, you will have the prolonged effect due to the extended half-life.
The grapefruit effect might last as long as 24 hours, or as little as six hours, depending both on dose and your own genetic makeup.
Lar
Posted by Larry Hoover on December 26, 2004, at 15:46:46
In reply to Correction - Sorry, posted by jujube on December 26, 2004, at 15:03:18
> The first website is actually
>
> http://www.mhc.com/Cytochromes/GFJ.HTMLGood article. It says that the high bioavailability of alprazolam minimizes the grapefruit effect. I hadn't seen that mentioned before, and it makes sense.
Lar
Posted by ghost on December 26, 2004, at 16:31:49
In reply to Re: Correction - Sorry » jujube, posted by Larry Hoover on December 26, 2004, at 15:46:46
thanks.
i think the baby definitions you gave will have to be enough for now, as i cant comprehend the long scientific stuff (let's hope that goes away before work tomorrow!) but i'll read the articles soon.
thanks again. this helped a great deal.
ghost
Posted by Fallen4MyT on December 26, 2004, at 17:45:37
In reply to Re: grapefruit (fruit and juice) and xanax interaction » ghost, posted by Larry Hoover on December 26, 2004, at 15:38:09
So if I take a valium and drink the grapfruit juice I will FEEL the valium more and longer??????? Thanks ahead for the help on this
Posted by Larry Hoover on December 26, 2004, at 19:22:27
In reply to Re: grapefruit (fruit and juice) ??????????LARRY, posted by Fallen4MyT on December 26, 2004, at 17:45:37
> So if I take a valium and drink the grapfruit juice I will FEEL the valium more and longer??????? Thanks ahead for the help on this
Diazepam is a little bit different than alprazolam. There are four different metabolic routes for diazepam. Four different enzymes, and only of them blocked by grapefruit juice. The metabolites of diazepam have some activity, too, so it's pretty hard to say just what the outcome would be. But, yes, in general, the effect of the diazepam would be intensified and lengthened. To what extent is not easily predicted. The difference might be too small to notice.
Lar
Posted by Fallen4MyT on December 26, 2004, at 19:34:42
In reply to Re: grapefruit (fruit and juice) ??????????LARRY » Fallen4MyT, posted by Larry Hoover on December 26, 2004, at 19:22:27
Thanks Larry...damn one could hope to save cash on the valium by drinking juice to boost it :)
Posted by Larry Hoover on December 26, 2004, at 20:02:17
In reply to Re: grapefruit (fruit and juice) ??????????LARRY » Larry Hoover, posted by Fallen4MyT on December 26, 2004, at 19:34:42
> Thanks Larry...damn one could hope to save cash on the valium by drinking juice to boost it :)
Might still be worthy of an experiment?
Lar
Posted by Fallen4MyT on December 26, 2004, at 20:05:35
In reply to Re: grapefruit (fruit and juice) ??????????LARRY » Fallen4MyT, posted by Larry Hoover on December 26, 2004, at 20:02:17
LMAO You're a mind reader :) and I know a pal who takes xanax who may save on some co-pays :P
Again thank you
> > Thanks Larry...damn one could hope to save cash on the valium by drinking juice to boost it :)
>
> Might still be worthy of an experiment?
>
> Lar
>
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