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Re: grapefruit (fruit and juice) and xanax interaction » ghost

Posted by Larry Hoover on December 26, 2004, at 15:38:09

In reply to grapefruit (fruit and juice) and xanax interaction, posted by ghost on December 26, 2004, at 14:13:29

> anyone know anything about it? i'm googling the wrong things, apparently, because i keep getting weird spam sites.
>
> my mom sent me a box of florida oranges, grapefruits, and a lime, and i'm wondering what i have to worry about since the bottle says to avoid grapefruit and grapefruit juice while taking it.
>
> any help is appreciated!
>
>
> ghost

Alprazolam is metabolized by the enzyme 3A4. Grapefruit and its juice inhibit that enzyme. If that enzyme is inhibited while you have alprazolam in your system, it will remain more active than it otherwise would have. That is to say, its half-life will be extended. If you take the grapefruit before the alprazolam, you will have an additional effect, as 3A4 also exists in the intestinal wall. You will have an effect as if you took more alprazolam than you actually did, and, you will have the prolonged effect due to the extended half-life.

The grapefruit effect might last as long as 24 hours, or as little as six hours, depending both on dose and your own genetic makeup.

Lar

 

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poster:Larry Hoover thread:434329
URL: http://www.dr-bob.org/babble/20041223/msgs/434345.html