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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by banga on July 24, 2004, at 19:10:02
Hope its not an obvious question, couldn't find an estimate...
Posted by SLS on July 24, 2004, at 19:31:33
In reply to What is the expected release date of Cymbalta?, posted by banga on July 24, 2004, at 19:10:02
> Hope its not an obvious question, couldn't find an estimate...
The FDA announced that it would make its decision in late September.
- Scott
Posted by ST on July 25, 2004, at 23:58:01
In reply to What is the expected release date of Cymbalta?, posted by banga on July 24, 2004, at 19:10:02
Hi,
I tried doing an archive search, but couldn't find out exactly what it is.
Thanks
ST
Posted by SLS on July 26, 2004, at 6:40:40
In reply to What is Cymbalta?, posted by ST on July 25, 2004, at 23:58:01
> Hi,
> I tried doing an archive search, but couldn't find out exactly what it is.
> Thanks
> STCymbalta (duloxetine) is an antidepressant developed by Eli Lilly (makers of Prozac and Zyprexa) that is not yet approved by the FDA. It has some similarities to Effexor (venlafaxine). It inhibits the reuptake of both norepinephrine (NE) and serotonin (5-HT), but in a manner that is more balanced than that seen with Effexor. If the premarketing literature is to be believed, it promises to be a very effective antidepressant that will probably help a greater percentage of people than any of the SSRIs.
- Scott
Posted by ST on July 26, 2004, at 16:03:23
In reply to Re: What is Cymbalta?, posted by SLS on July 26, 2004, at 6:40:40
Wow. Thanks for the info. I found Effexor to be a great AD, but it's side effects when missing a dose by an hour or so were brutal. Maybe this will be the best of Effexor...who knows....
ST
Posted by cpallen79 on July 26, 2004, at 20:42:04
In reply to Re: What is Cymbalta?, posted by ST on July 26, 2004, at 16:03:23
I'm somewhat excited by this one too. The thing with effexor is that things can get really hosed because it works on different things are various levels. I would think that by having a more balanced reuptake inhibiton that the Cymbalta will be much smoother. the only thing I'm weary of is that short half life... we all know what effexor w/d is like, hopefully this one won't be as nasty.
> Wow. Thanks for the info. I found Effexor to be a great AD, but it's side effects when missing a dose by an hour or so were brutal. Maybe this will be the best of Effexor...who knows....
> ST
Posted by banga on July 26, 2004, at 23:49:14
In reply to Re: What is Cymbalta?, posted by cpallen79 on July 26, 2004, at 20:42:04
Thanks everyone! I guess I will have to wait and see how it works out.
Banga
Posted by KaraS on July 26, 2004, at 23:59:49
In reply to Re: What is Cymbalta?, posted by banga on July 26, 2004, at 23:49:14
Just wanted to add another bit of information on the more balanced reuptake of Cymbalta. I believe that Effexor is mostly serotonergic until you hit 225 mg. and then some of the noradrenergic effects kick in. I don't think it ever gets to being 50/50 at any dosage. (Scott?)
Cymbalta is supposed to be closer to 50/50 from the start.
Posted by sageblue on July 27, 2004, at 0:33:49
In reply to What is Cymbalta?, posted by ST on July 25, 2004, at 23:58:01
i always thought that cymbalta was an attempt to clean up serzone, much in the way that lexapro sought to eliminate the unpleasant effects of celexa. am i wrong?
Posted by SLS on July 27, 2004, at 7:08:07
In reply to Re: What is Cymbalta?, posted by KaraS on July 26, 2004, at 23:59:49
Although Cymbalta (duloxetine) is more balanced than Effexor (venlafaxine) in inhibiting the reuptake of serotonin (5-HT) compared to norepinephrine (NE), it is still skewed towards serotonin. It is difficult to estimate the differences between the two drugs in the real world, though. One study by Eli Lilly estimates the ratios of 5-HT/NE transporter binding affinity to to be 9 for duloxetine and 30 for venlafaxine. This is not a measurement of reuptake inhibition, however, and my guess is that the differences between the two drugs is greater than these numbers suggest.
- Scott
Posted by KaraS on July 27, 2004, at 14:08:18
In reply to Re: What is Cymbalta?, posted by sageblue on July 27, 2004, at 0:33:49
> i always thought that cymbalta was an attempt to clean up serzone, much in the way that lexapro sought to eliminate the unpleasant effects of celexa. am i wrong?
Maybe you have Cymbalta confused with something else?
Posted by chemist on July 27, 2004, at 20:54:57
In reply to Re: What is Cymbalta?, posted by KaraS on July 27, 2004, at 14:08:18
> > i always thought that cymbalta was an attempt to clean up serzone, much in the way that lexapro sought to eliminate the unpleasant effects of celexa. am i wrong?
>
>
>
> Maybe you have Cymbalta confused with something else?hello there, chemist here....the case of (R,S)-citalopram (celexa) -> (S)-citalopram (lexapro) is not the case with duloxetine. different structure entirely than nefazodone...although i believe the drug will be an enantiomerically-pure one, (such as lexapro)....all the best, chemist
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