Re: What is Cymbalta?

Posted by SLS on July 27, 2004, at 7:08:07

In reply to Re: What is Cymbalta?, posted by KaraS on July 26, 2004, at 23:59:49

Although Cymbalta (duloxetine) is more balanced than Effexor (venlafaxine) in inhibiting the reuptake of serotonin (5-HT) compared to norepinephrine (NE), it is still skewed towards serotonin. It is difficult to estimate the differences between the two drugs in the real world, though. One study by Eli Lilly estimates the ratios of 5-HT/NE transporter binding affinity to to be 9 for duloxetine and 30 for venlafaxine. This is not a measurement of reuptake inhibition, however, and my guess is that the differences between the two drugs is greater than these numbers suggest.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11750180

- Scott

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What is the expected release date of Cymbalta? banga 7/24/04
Re: What is the expected release date of Cymbalta? SLS 7/24/04
What is Cymbalta? ST 7/25/04
Re: What is Cymbalta? SLS 7/26/04
Re: What is Cymbalta? ST 7/26/04
Re: What is Cymbalta? cpallen79 7/26/04
Re: What is Cymbalta? banga 7/26/04
Re: What is Cymbalta? KaraS 7/26/04
Re: What is Cymbalta? sageblue 7/27/04
Re: What is Cymbalta? SLS 7/27/04
Re: What is Cymbalta? KaraS 7/27/04
Re: What is Cymbalta? » KaraS chemist 7/27/04

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