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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by don_bristol on June 2, 2004, at 3:57:14
I read somewhere (I can't remember where) that the potentially dangerous hypertensive food interaction of MAOIs with certain foods is generally *not* dependent on the dose of the MAOI.
Is this true?
So if I take 20 mg of Parnate am I equally susceptible to a food interacation as if I took 40 or 50 mg?
And what about food interaction with those impressive doses I read about on message boards like 80mg or 120 mg Parnate daily?
Posted by djmmm on June 2, 2004, at 6:13:25
In reply to Food interaction *not* depend on MAOI dose?, posted by don_bristol on June 2, 2004, at 3:57:14
> I read somewhere (I can't remember where) that the potentially dangerous hypertensive food interaction of MAOIs with certain foods is generally *not* dependent on the dose of the MAOI.
>
> Is this true?
>
> So if I take 20 mg of Parnate am I equally susceptible to a food interacation as if I took 40 or 50 mg?
>
> And what about food interaction with those impressive doses I read about on message boards like 80mg or 120 mg Parnate daily?Hypertensive reactions depend on the amount or % of MAO inhibited, which, like a positive therapeutic effect, is often independent of the actual dosage
Posted by gardenergirl on June 2, 2004, at 17:23:13
In reply to Re: Food interaction *not* depend on MAOI dose?, posted by djmmm on June 2, 2004, at 6:13:25
In addition, it depends on the amount of tyramine ingested.
gg
Posted by Questionmark on June 3, 2004, at 0:47:58
In reply to Food interaction *not* depend on MAOI dose?, posted by don_bristol on June 2, 2004, at 3:57:14
> I read somewhere (I can't remember where) that the potentially dangerous hypertensive food interaction of MAOIs with certain foods is generally *not* dependent on the dose of the MAOI.
>
> Is this true?
>
> So if I take 20 mg of Parnate am I equally susceptible to a food interacation as if I took 40 or 50 mg?
>
> And what about food interaction with those impressive doses I read about on message boards like 80mg or 120 mg Parnate daily?i have a really hard time believing that. While i agree with djmmm and gardenergirl, the higher one's MAOI dose, the greater the extent of thAt individual's MAO inhibition should be. And yes it depends on the amount of tyramine ingested as well, but the same amount of ingested tyramine will have a greater effect with lower levels of MAO enzyme than higher levels. i do not see how what you read would make any sense or be accurate.
Someone please correct me if i'm wrong, however.
Posted by tepiaca on June 3, 2004, at 0:48:58
In reply to Re: Food interaction *not* depend on MAOI dose?, posted by gardenergirl on June 2, 2004, at 17:23:13
I wonder this:
What IF I eat a big peace of chesse or anything with high quiantities of tyramine and right away I takek my nifedipine pill?or further more, wait until I start feeling the headache , then I take my pill inmediately
what do you think about this?
Posted by Chairman_MAO on June 3, 2004, at 10:51:30
In reply to chesse in one hand and nifedipine in the other, posted by tepiaca on June 3, 2004, at 0:48:58
The phrase "Russian Roulette" comes to mind.
> I wonder this:
> What IF I eat a big peace of chesse or anything with high quiantities of tyramine and right away I takek my nifedipine pill?
>
> or further more, wait until I start feeling the headache , then I take my pill inmediately
>
> what do you think about this?
>
Posted by King Vultan on June 3, 2004, at 12:35:25
In reply to chesse in one hand and nifedipine in the other, posted by tepiaca on June 3, 2004, at 0:48:58
> I wonder this:
> What IF I eat a big peace of chesse or anything with high quiantities of tyramine and right away I takek my nifedipine pill?
>
> or further more, wait until I start feeling the headache , then I take my pill inmediately
>
> what do you think about this?
>
It sounds extremely unwise to deliberately place yourself in danger. There are some risks with the nifedipine also--some doctors feel it should not be prescribed to MAOI patients for emergencies (I respectfully disagree).Todd
Posted by kellym on June 3, 2004, at 23:57:09
In reply to Re: Food interaction *not* depend on MAOI dose? » don_bristol, posted by Questionmark on June 3, 2004, at 0:47:58
> > I read somewhere (I can't remember where) that the potentially dangerous hypertensive food interaction of MAOIs with certain foods is generally *not* dependent on the dose of the MAOI.
> >
> > Is this true?
> >
> > So if I take 20 mg of Parnate am I equally susceptible to a food interacation as if I took 40 or 50 mg?
> >
> > And what about food interaction with those impressive doses I read about on message boards like 80mg or 120 mg Parnate daily?
>
>
>
> i have a really hard time believing that. While i agree with djmmm and gardenergirl, the higher one's MAOI dose, the greater the extent of thAt individual's MAO inhibition should be. And yes it depends on the amount of tyramine ingested as well, but the same amount of ingested tyramine will have a greater effect with lower levels of MAO enzyme than higher levels. i do not see how what you read would make any sense or be accurate.
> Someone please correct me if i'm wrong, however.All things being equal, I have a hard time believing this as well. My only thought is that this may be a very general statement. Perhaps the point to be made is that MAO inhibition can occur at a relatively low dose (occasionally even spontaneous reactions without ingesting tyramine). If you metabolize the drug slowly, the more chance a lower dose could cause prolems. Again just speculating.
This is the end of the thread.
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