![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by ace on May 2, 2004, at 23:56:48
Chemist!
Do you think Remeron and Nardil is a safe combo...
BTW, I checked you out through google...man, your profile is impressive!Take Care,
Ace
Posted by chemist on May 3, 2004, at 0:31:31
In reply to ATTN: Chemist! Your opinion on MAOI + Remeron..., posted by ace on May 2, 2004, at 23:56:48
> Chemist!
>
> Do you think Remeron and Nardil is a safe combo...
>
>
> BTW, I checked you out through google...man, your profile is impressive!
>
> Take Care,
> Acethanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
Posted by Sad Panda on May 4, 2004, at 14:06:24
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » ace, posted by chemist on May 3, 2004, at 0:31:31
> > Chemist!
> >
> > Do you think Remeron and Nardil is a safe combo...
> >
> >
> > BTW, I checked you out through google...man, your profile is impressive!
> >
> > Take Care,
> > Ace
>
> thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
>
>Hi Chemist,
AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
Cheers,
Panda.
Posted by chemist on May 4, 2004, at 15:28:58
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 4, 2004, at 14:06:24
> > > Chemist!
> > >
> > > Do you think Remeron and Nardil is a safe combo...
> > >
> > >
> > > BTW, I checked you out through google...man, your profile is impressive!
> > >
> > > Take Care,
> > > Ace
> >
> > thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
> >
> >
>
> Hi Chemist,
>
> AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
>
> Cheers,
> Panda.
>
>
>
hi panda....as you correctly state, remeron is not a serotonin or norepinephrine reuptake inhibitor. however, by antagonizing the alpha_{2} adrenergic receptor which subsequently leads to increaded serotonin and norepinephrine levels. the fact that it is NOT an SRI or NRI and that it stimulates higher levels of S and N makes it even more dangerous if used with an MAOI.....all the best, chemist
Posted by Sad Panda on May 4, 2004, at 15:59:08
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » Sad Panda, posted by chemist on May 4, 2004, at 15:28:58
> > > > Chemist!
> > > >
> > > > Do you think Remeron and Nardil is a safe combo...
> > > >
> > > >
> > > > BTW, I checked you out through google...man, your profile is impressive!
> > > >
> > > > Take Care,
> > > > Ace
> > >
> > > thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
> > >
> > >
> >
> > Hi Chemist,
> >
> > AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
> >
> > Cheers,
> > Panda.
> >
> >
> >
> hi panda....as you correctly state, remeron is not a serotonin or norepinephrine reuptake inhibitor. however, by antagonizing the alpha_{2} adrenergic receptor which subsequently leads to increaded serotonin and norepinephrine levels. the fact that it is NOT an SRI or NRI and that it stimulates higher levels of S and N makes it even more dangerous if used with an MAOI.....all the best, chemist
>
>Hi Chemist,
I thought that effect was more theoretical rather than actual & it has never been proven that Remeron increase serotonin or norepinephrine levels.
Cheers,
Panda.
Posted by chemist on May 4, 2004, at 16:57:02
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 4, 2004, at 15:59:08
> > > > > Chemist!
> > > > >
> > > > > Do you think Remeron and Nardil is a safe combo...
> > > > >
> > > > >
> > > > > BTW, I checked you out through google...man, your profile is impressive!
> > > > >
> > > > > Take Care,
> > > > > Ace
> > > >
> > > > thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
> > > >
> > > >
> > >
> > > Hi Chemist,
> > >
> > > AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
> > >
> > > Cheers,
> > > Panda.
> > >
> > >
> > >
> > hi panda....as you correctly state, remeron is not a serotonin or norepinephrine reuptake inhibitor. however, by antagonizing the alpha_{2} adrenergic receptor which subsequently leads to increaded serotonin and norepinephrine levels. the fact that it is NOT an SRI or NRI and that it stimulates higher levels of S and N makes it even more dangerous if used with an MAOI.....all the best, chemist
> >
> >
>
> Hi Chemist,
>
> I thought that effect was more theoretical rather than actual & it has never been proven that Remeron increase serotonin or norepinephrine levels.
>
> Cheers,
> Panda.
>
>
>
see Mol. Psychiatry 8:994-1007 (2003) for experimental confirmation that mirtazapine is an antagonist of 5-HT_{3};Neuropsychobiology 47:31-36 (2003) for experimental confirmation of mirtazapine reduces hypercorisolism and is an antagonist of 5-HT_{2}, 5-HT_{3} and H_{1};
Am. Fam. Physician 67:547-554 (2003) for a review, in the abstract it is stated ``Mirtazapine...is unique in its action -- stimulating the release of norepinephrine and serontonin.'' (i assume they do cite the appropriate refs therein);
Int. Clin. Psychopharmacol. 17:319-322 (2002) for mirtazapine antagonizing alpha2-adrenergic receptors with result of increased norepinephrine and serotonin activity; ``Histamine H2 receptors are also antagonized, as are postsynaptic serotonin 5-HT2 and 5-HT3 receptors, leading to serotonergic activity primarily via 5-HT1A receptors.''
Hum. Psychopharmacol. 17 Supp 1:S17-22 (2002) for ``Cell firing is reduced by SSRIs in the short-term, but is increased by mirtazapine, probably due to its actions on both NA (via alpha(2) antagonism) and 5-HT (via alpha(1)-stimulation by NA).''
all the best, chemist
Posted by BobS, on May 4, 2004, at 20:21:45
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » Sad Panda, posted by chemist on May 4, 2004, at 16:57:02
Chemist,
Hello again. I am at the two week point on Remeron with quite a favorable response (15mgs).I find this medication fascinating from a layman's perspective. Do you have Pub Med citations for the articles you posted, or should I just search on mirtazapine and look for the journal titles? I am really curious about how this medication works (anxiety and depression) and how it differs from SSRIs. I am intolerable to the latter.
Also, do you have any thoughts on Gepirone and it's mechanism of action? Is it similar to Remeron?
Thanks,
BobS.
Posted by chemist on May 4, 2004, at 20:25:17
In reply to Re: ATTN: Chemist! Please translate citations, posted by BobS, on May 4, 2004, at 20:21:45
> Chemist,
> Hello again. I am at the two week point on Remeron with quite a favorable response (15mgs).
>
> I find this medication fascinating from a layman's perspective. Do you have Pub Med citations for the articles you posted, or should I just search on mirtazapine and look for the journal titles? I am really curious about how this medication works (anxiety and depression) and how it differs from SSRIs. I am intolerable to the latter.
>
> Also, do you have any thoughts on Gepirone and it's mechanism of action? Is it similar to Remeron?
> Thanks,
> BobS.hi bob, those citations were from pubmed, keywords mirtazapine serotonin and norepinephrine, and have a look at the abstracts: a well-written one will give you the brass-tacks aspect of the studies, and Related and/or Cited links for one that grabs your fancy will be more revealing....as for gepirone, i do not know anything about it, but i suspect there are some hits on pubmed :)...all the best, chemist
Posted by Sad Panda on May 5, 2004, at 13:33:41
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » Sad Panda, posted by chemist on May 4, 2004, at 16:57:02
> > > > > > Chemist!
> > > > > >
> > > > > > Do you think Remeron and Nardil is a safe combo...
> > > > > >
> > > > > >
> > > > > > BTW, I checked you out through google...man, your profile is impressive!
> > > > > >
> > > > > > Take Care,
> > > > > > Ace
> > > > >
> > > > > thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
> > > > >
> > > > >
> > > >
> > > > Hi Chemist,
> > > >
> > > > AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
> > > >
> > > > Cheers,
> > > > Panda.
> > > >
> > > >
> > > >
> > > hi panda....as you correctly state, remeron is not a serotonin or norepinephrine reuptake inhibitor. however, by antagonizing the alpha_{2} adrenergic receptor which subsequently leads to increaded serotonin and norepinephrine levels. the fact that it is NOT an SRI or NRI and that it stimulates higher levels of S and N makes it even more dangerous if used with an MAOI.....all the best, chemist
> > >
> > >
> >
> > Hi Chemist,
> >
> > I thought that effect was more theoretical rather than actual & it has never been proven that Remeron increase serotonin or norepinephrine levels.
> >
> > Cheers,
> > Panda.
> >
> >
> >
> see Mol. Psychiatry 8:994-1007 (2003) for experimental confirmation that mirtazapine is an antagonist of 5-HT_{3};
>
> Neuropsychobiology 47:31-36 (2003) for experimental confirmation of mirtazapine reduces hypercorisolism and is an antagonist of 5-HT_{2}, 5-HT_{3} and H_{1};
>
> Am. Fam. Physician 67:547-554 (2003) for a review, in the abstract it is stated ``Mirtazapine...is unique in its action -- stimulating the release of norepinephrine and serontonin.'' (i assume they do cite the appropriate refs therein);
>
> Int. Clin. Psychopharmacol. 17:319-322 (2002) for mirtazapine antagonizing alpha2-adrenergic receptors with result of increased norepinephrine and serotonin activity; ``Histamine H2 receptors are also antagonized, as are postsynaptic serotonin 5-HT2 and 5-HT3 receptors, leading to serotonergic activity primarily via 5-HT1A receptors.''
>
> Hum. Psychopharmacol. 17 Supp 1:S17-22 (2002) for ``Cell firing is reduced by SSRIs in the short-term, but is increased by mirtazapine, probably due to its actions on both NA (via alpha(2) antagonism) and 5-HT (via alpha(1)-stimulation by NA).''
>
> all the best, chemist
>
>Hi Chemist,
None of those have any real proof that serotonin levels are raised. Have you got any others to look at?
Cheers,
Panda.
Posted by chemist on May 5, 2004, at 14:28:19
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 5, 2004, at 13:33:41
> > > > > > > Chemist!
> > > > > > >
> > > > > > > Do you think Remeron and Nardil is a safe combo...
> > > > > > >
> > > > > > >
> > > > > > > BTW, I checked you out through google...man, your profile is impressive!
> > > > > > >
> > > > > > > Take Care,
> > > > > > > Ace
> > > > > >
> > > > > > thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
> > > > > >
> > > > > >
> > > > >
> > > > > Hi Chemist,
> > > > >
> > > > > AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
> > > > >
> > > > > Cheers,
> > > > > Panda.
> > > > >
> > > > >
> > > > >
> > > > hi panda....as you correctly state, remeron is not a serotonin or norepinephrine reuptake inhibitor. however, by antagonizing the alpha_{2} adrenergic receptor which subsequently leads to increaded serotonin and norepinephrine levels. the fact that it is NOT an SRI or NRI and that it stimulates higher levels of S and N makes it even more dangerous if used with an MAOI.....all the best, chemist
> > > >
> > > >
> > >
> > > Hi Chemist,
> > >
> > > I thought that effect was more theoretical rather than actual & it has never been proven that Remeron increase serotonin or norepinephrine levels.
> > >
> > > Cheers,
> > > Panda.
> > >
> > >
> > >
> > see Mol. Psychiatry 8:994-1007 (2003) for experimental confirmation that mirtazapine is an antagonist of 5-HT_{3};
> >
> > Neuropsychobiology 47:31-36 (2003) for experimental confirmation of mirtazapine reduces hypercorisolism and is an antagonist of 5-HT_{2}, 5-HT_{3} and H_{1};
> >
> > Am. Fam. Physician 67:547-554 (2003) for a review, in the abstract it is stated ``Mirtazapine...is unique in its action -- stimulating the release of norepinephrine and serontonin.'' (i assume they do cite the appropriate refs therein);
> >
> > Int. Clin. Psychopharmacol. 17:319-322 (2002) for mirtazapine antagonizing alpha2-adrenergic receptors with result of increased norepinephrine and serotonin activity; ``Histamine H2 receptors are also antagonized, as are postsynaptic serotonin 5-HT2 and 5-HT3 receptors, leading to serotonergic activity primarily via 5-HT1A receptors.''
> >
> > Hum. Psychopharmacol. 17 Supp 1:S17-22 (2002) for ``Cell firing is reduced by SSRIs in the short-term, but is increased by mirtazapine, probably due to its actions on both NA (via alpha(2) antagonism) and 5-HT (via alpha(1)-stimulation by NA).''
> >
> > all the best, chemist
> >
> >
>
> Hi Chemist,
>
> None of those have any real proof that serotonin levels are raised. Have you got any others to look at?
>
> Cheers,
> Panda.
>
>
hey panda gimme some time, i will dig up the goods, although the post by ace pretty much makes my assertion that remeron+nardil=bad moot....back at you later, thanks, and all the best, chemist
Posted by chemist on May 5, 2004, at 14:54:19
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 5, 2004, at 13:33:41
hey panda.....the best one i found was in Mol. Psychiatry, where is is stated (i;m going on the abstract here) that ``...desipramine, imipramine, trimipramine,...fluoxetine,...reboxetine,...and mirtazapine effectively reduced the serotonin-induced Na(+) and Ca(2+) currents in a dose-dependent fashion. This effect was voltage-independent and, with the exception of mirtazapine, noncompetitive.'' if the currents were serotonin-induced, and mirtazapine reduced them - keeping in mind that they were only looking at 5-HT3A human and 5-HT3 rat, so no andrenergic sites to go running off to - i'm guessing this is evidence that mirtazapine is actually binding in the active site of the receptors. the qualifier that mirtazapine was the only one of the antidepressants listed above that that competitively bound to the receptor is in line with it being less of a SSRI than the others but does have some affinity......all the best, chemist
Posted by chemist on May 5, 2004, at 15:10:36
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 5, 2004, at 13:33:41
panda, check out Behav. Brain Res. 136:521-532 (2002), where in a rat forced swimming test, ``...chronic but not subacute-mirtazapine increases swimming behaviour,'' which is apparently a ``yes'' for mirtazapine being a selective serotonin reuptake-inhibitor...(i was unaware that selective noradrenaline reuptake-inhibitors increase climbing behaviour of rats, i learn something new every day)....anyhow, this is as good as i can come to it, and again, Ace's experiment with nardil+remeron being a pleasant one, i'll cede! all the best, chemist
Posted by flipsactown on May 5, 2004, at 16:30:43
In reply to one more for Panda.... » Sad Panda, posted by chemist on May 5, 2004, at 15:10:36
Chemist,
Please check out this website that addresses Remeron use with MAOI.
http://www.currentpsychiatry.com/2002_06/06_02_maoi.asp
"Trazodone is frequently employed as a remedy for MAOI-induced insomnia.19 Mirtazapine can be used safely in combination with MAOIs, and the agent has been reported to acutely treat serotonin syndrome.20"
Check out footnote 20. Citation for quoted statement regarding Remeron use with MAOI.
I have also used for only one night taking 22.5mg Remeron. I took Remeron before Ace. Refer to posts between Ace and myself. I am currently taking 60mg of Nardil. I temporarily stopped taking the Remeron because I am in the tail end of home detox from Oxy and wanted to wait until I was totally Oxy free which will be in 4 to 5 weeks. I was on 160mg of Oxy and am down to 40mg tapering down by 20mg every two weeks. However, for each 20mg Oxy I stop taking, I added 30mg Tylenol Codeine. Eventually, I will be on 240mg Tylenol Codeine daily only. Prior to taking Oxy which I have been taking over 2 years, I was on Codeine for over 5 years, and did not suffer withdrawals ,like I did on Oxy, which I accidently experienced when I ran out of Oxy prematurely. With Codeine, I could go without for a day, week, or month without experiencing dts. Home detox was setup by my pain doc.
FST
> panda, check out Behav. Brain Res. 136:521-532 (2002), where in a rat forced swimming test, ``...chronic but not subacute-mirtazapine increases swimming behaviour,'' which is apparently a ``yes'' for mirtazapine being a selective serotonin reuptake-inhibitor...(i was unaware that selective noradrenaline reuptake-inhibitors increase climbing behaviour of rats, i learn something new every day)....anyhow, this is as good as i can come to it, and again, Ace's experiment with nardil+remeron being a pleasant one, i'll cede! all the best, chemist
Posted by chemist on May 5, 2004, at 20:58:27
In reply to Chemist: Remeron taken with MAOI » chemist, posted by flipsactown on May 5, 2004, at 16:30:43
many thanks for the ref! all the best, chemist
Posted by Random987 on May 27, 2004, at 19:11:59
In reply to Re: Chemist: Remeron taken with MAOI, posted by chemist on May 5, 2004, at 20:58:27
This is a bit off topic, but I was wondering how Remeron reacts to Deprenyl (at lower dosages a selective MAO B inhibitor.
Here is an interesting abstract regarding folks taking Deprenyl for Parkinson's who are also taking antidepressants:
Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson's disease. Parkinson Study Group.Richard IH, Kurlan R, Tanner C, Factor S, Hubble J, Suchowersky O, Waters C.
University of Rochester Medical Center, Department of Neurology, NY 14642-8673, USA.
The manufacturer of deprenyl (selegeline; Eldepryl) (Somerset Pharmaceuticals, Tampa, FL) recently advised physicians to avoid prescribing the drug in combination with an antidepressant because of potentially serious CNS toxicity that may represent the serotonin syndrome. Manifestations of the serotonin syndrome vary but may include changes in mental status and motor and autonomic function. To better estimate the frequency of the serotonin syndrome in patients with Parkinson's disease (PD) treated with deprenyl and an antidepressant, we surveyed all investigators in the Parkinson Study Group. Based on estimates provided by the 47 investigators (75%) who responded, 4,568 patients were treated with the combination of deprenyl and an antidepressant medication. Eleven patients (0.24%) were reported to have experienced symptoms possibly consistent with the serotonin syndrome. Only two patients (0.04%) experienced symptoms considered to be serious. No deaths were reported. We also reviewed all published case reports and adverse experiences reported to the U.S. Food and Drug Administration and the manufacturer of Eldepryl. Available information indicates that serious adverse experiences resulting from the combined use of deprenyl and an antidepressant medication in patients with PD are quite rare and that the frequency of the true "serotonin syndrome" is even rarer.
So from the abstract it appears that there shouldn't be a problem with taking deprenyl and remeron, n'est pas?
Posted by chemist on May 29, 2004, at 0:34:34
In reply to Re: Chemist: Remeron taken with MAOI, posted by Random987 on May 27, 2004, at 19:11:59
hello, chemist here... i am going to defer to sad panda, king vultan jlb121, SLS, and ace on this one. your info sounds good, but i am not in the know as are the other folks....with many apologies and best wishes, chemist
> This is a bit off topic, but I was wondering how Remeron reacts to Deprenyl (at lower dosages a selective MAO B inhibitor.
>
> Here is an interesting abstract regarding folks taking Deprenyl for Parkinson's who are also taking antidepressants:
> Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson's disease. Parkinson Study Group.
>
> Richard IH, Kurlan R, Tanner C, Factor S, Hubble J, Suchowersky O, Waters C.
>
> University of Rochester Medical Center, Department of Neurology, NY 14642-8673, USA.
>
> The manufacturer of deprenyl (selegeline; Eldepryl) (Somerset Pharmaceuticals, Tampa, FL) recently advised physicians to avoid prescribing the drug in combination with an antidepressant because of potentially serious CNS toxicity that may represent the serotonin syndrome. Manifestations of the serotonin syndrome vary but may include changes in mental status and motor and autonomic function. To better estimate the frequency of the serotonin syndrome in patients with Parkinson's disease (PD) treated with deprenyl and an antidepressant, we surveyed all investigators in the Parkinson Study Group. Based on estimates provided by the 47 investigators (75%) who responded, 4,568 patients were treated with the combination of deprenyl and an antidepressant medication. Eleven patients (0.24%) were reported to have experienced symptoms possibly consistent with the serotonin syndrome. Only two patients (0.04%) experienced symptoms considered to be serious. No deaths were reported. We also reviewed all published case reports and adverse experiences reported to the U.S. Food and Drug Administration and the manufacturer of Eldepryl. Available information indicates that serious adverse experiences resulting from the combined use of deprenyl and an antidepressant medication in patients with PD are quite rare and that the frequency of the true "serotonin syndrome" is even rarer.
>
> So from the abstract it appears that there shouldn't be a problem with taking deprenyl and remeron, n'est pas?
>
>
Posted by Random987 on May 29, 2004, at 3:10:37
In reply to Re: Chemist: Remeron taken with MAOI » Random987, posted by chemist on May 29, 2004, at 0:34:34
Thanks,
Given the study I posted, it appears that there is less then 1/2 of one percent of having a problem if you take Remeron and Deprneyl....
Posted by Sad Panda on May 29, 2004, at 3:51:30
In reply to Re: Chemist: Remeron taken with MAOI, posted by Random987 on May 29, 2004, at 3:10:37
> Thanks,
>
> Given the study I posted, it appears that there is less then 1/2 of one percent of having a problem if you take Remeron and Deprneyl....
>
>Theoretically, Remeron raises serotonin levels, but in reality it is an insignificant amount, so serotonin syndrome is very remote & probably only likely to occur to people who are extremely med sensitive. Remeron also raises NE at high doseages via Alpha-2 NE antagonism, but retains enough Alpha-1 NE antagonism to keep blood pressure down.
If you want a sedative AD to combine with an MAOI, I believe that low dose doxepin would be a good choice or high dose nortriptyline if you are looking to for some additional AD effect. These two are both NRI which would block tyramine from being taken up & they are 5-HT2A blockers which is believed to be the mechanism for reversing serotonin syndrome.
Also, low dose or high dose Deprenyl are two differnt things. Low dose it's a MAO-B inhibitor, which means serotonin or NE are not raised, high dose it becomes non-selective & it's said that it closely resembles Parnate.
Cheers,
Panda.
Posted by Random987 on May 29, 2004, at 13:43:58
In reply to Re: Chemist: Remeron taken with MAOI » Random987, posted by Sad Panda on May 29, 2004, at 3:51:30
Hmmm...I am taking remeron primarily to help sleep maintenance insomnia. 15mg before bed. The AD effect is a secondary benefit. The Deprenyl is more of a wellness supplement at a very low dose. I feel a lot better when taking just a little deprenyl in the morning.
Can remeron raise blood pressure? I have been experiencing a high dystolic the last couple of months and was wondering where it came from....also I am on testosterone replacement for hypogonadisim (lots of stuff going on!)
> Theoretically, Remeron raises serotonin levels, but in reality it is an insignificant amount, so serotonin syndrome is very remote & probably only likely to occur to people who are extremely med sensitive. Remeron also raises NE at high doseages via Alpha-2 NE antagonism, but retains enough Alpha-1 NE antagonism to keep blood pressure down.
>
> If you want a sedative AD to combine with an MAOI, I believe that low dose doxepin would be a good choice or high dose nortriptyline if you are looking to for some additional AD effect. These two are both NRI which would block tyramine from being taken up & they are 5-HT2A blockers which is believed to be the mechanism for reversing serotonin syndrome.
>
> Also, low dose or high dose Deprenyl are two differnt things. Low dose it's a MAO-B inhibitor, which means serotonin or NE are not raised, high dose it becomes non-selective & it's said that it closely resembles Parnate.
>
> Cheers,
> Panda.
>
>
This is the end of the thread.
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