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Re: Chemist: Remeron taken with MAOI

Posted by Random987 on May 29, 2004, at 13:43:58

In reply to Re: Chemist: Remeron taken with MAOI » Random987, posted by Sad Panda on May 29, 2004, at 3:51:30

Hmmm...I am taking remeron primarily to help sleep maintenance insomnia. 15mg before bed. The AD effect is a secondary benefit. The Deprenyl is more of a wellness supplement at a very low dose. I feel a lot better when taking just a little deprenyl in the morning.

Can remeron raise blood pressure? I have been experiencing a high dystolic the last couple of months and was wondering where it came from....also I am on testosterone replacement for hypogonadisim (lots of stuff going on!)


> Theoretically, Remeron raises serotonin levels, but in reality it is an insignificant amount, so serotonin syndrome is very remote & probably only likely to occur to people who are extremely med sensitive. Remeron also raises NE at high doseages via Alpha-2 NE antagonism, but retains enough Alpha-1 NE antagonism to keep blood pressure down.
>
> If you want a sedative AD to combine with an MAOI, I believe that low dose doxepin would be a good choice or high dose nortriptyline if you are looking to for some additional AD effect. These two are both NRI which would block tyramine from being taken up & they are 5-HT2A blockers which is believed to be the mechanism for reversing serotonin syndrome.
>
> Also, low dose or high dose Deprenyl are two differnt things. Low dose it's a MAO-B inhibitor, which means serotonin or NE are not raised, high dose it becomes non-selective & it's said that it closely resembles Parnate.
>
> Cheers,
> Panda.
>
>


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