Posted by chemist on May 5, 2004, at 14:54:19
In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 5, 2004, at 13:33:41
hey panda.....the best one i found was in Mol. Psychiatry, where is is stated (i;m going on the abstract here) that ``...desipramine, imipramine, trimipramine,...fluoxetine,...reboxetine,...and mirtazapine effectively reduced the serotonin-induced Na(+) and Ca(2+) currents in a dose-dependent fashion. This effect was voltage-independent and, with the exception of mirtazapine, noncompetitive.'' if the currents were serotonin-induced, and mirtazapine reduced them - keeping in mind that they were only looking at 5-HT3A human and 5-HT3 rat, so no andrenergic sites to go running off to - i'm guessing this is evidence that mirtazapine is actually binding in the active site of the receptors. the qualifier that mirtazapine was the only one of the antidepressants listed above that that competitively bound to the receptor is in line with it being less of a SSRI than the others but does have some affinity......all the best, chemist
poster:chemist
thread:342638
URL: http://www.dr-bob.org/babble/20040505/msgs/343709.html