Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » Sad Panda

Posted by chemist on May 5, 2004, at 14:54:19

In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... » chemist, posted by Sad Panda on May 5, 2004, at 13:33:41

hey panda.....the best one i found was in Mol. Psychiatry, where is is stated (i;m going on the abstract here) that ``...desipramine, imipramine, trimipramine,...fluoxetine,...reboxetine,...and mirtazapine effectively reduced the serotonin-induced Na(+) and Ca(2+) currents in a dose-dependent fashion. This effect was voltage-independent and, with the exception of mirtazapine, noncompetitive.'' if the currents were serotonin-induced, and mirtazapine reduced them - keeping in mind that they were only looking at 5-HT3A human and 5-HT3 rat, so no andrenergic sites to go running off to - i'm guessing this is evidence that mirtazapine is actually binding in the active site of the receptors. the qualifier that mirtazapine was the only one of the antidepressants listed above that that competitively bound to the receptor is in line with it being less of a SSRI than the others but does have some affinity......all the best, chemist


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:chemist thread:342638
URL: http://www.dr-bob.org/babble/20040505/msgs/343709.html