Psycho-Babble Medication Thread 300883

Shown: posts 1 to 8 of 8. This is the beginning of the thread.

 

Ach(M) is this the dumb receptor

Posted by linkadge on January 14, 2004, at 20:06:49

I am looking at zyprexa, it has significant Ach(m) receptor activity. Is this the receptor that induces cognitive side effects ??

Thanks

Linkadge

 

Re: Ach(M) is this the dumb receptor

Posted by SLS on January 14, 2004, at 21:10:20

In reply to Ach(M) is this the dumb receptor, posted by linkadge on January 14, 2004, at 20:06:49

> I am looking at zyprexa, it has significant Ach(m) receptor activity. Is this the receptor that induces cognitive side effects ??
>

When antagonized, yes.

However, anticholinergic agents exert antidepressant effects for some people. Conversely (is that the right term in this case), pro-cholinergic drugs can induce depression. In my experience dosages of Zyprexa up to 10mg haven't really bothered me in the same way that imipramine does. I wouldn't make a decision about Zyprexa with anti-muscarinic properties as the criterion.

- Scott

 

Re: Ach(M) is this the dumb receptor

Posted by Keith Talent on January 14, 2004, at 21:41:40

In reply to Ach(M) is this the dumb receptor, posted by linkadge on January 14, 2004, at 20:06:49

Yes, but the dopamine 2 receptor blocking effect (what the drug is prescribed for) can slow thinking and make patients feel "locked in".

 

Re: Ach(M) is this the dumb receptor

Posted by SLS on January 14, 2004, at 21:44:42

In reply to Re: Ach(M) is this the dumb receptor, posted by Keith Talent on January 14, 2004, at 21:41:40

> Yes, but the dopamine 2 receptor blocking effect (what the drug is prescribed for) can slow thinking and make patients feel "locked in".
>

Risperdal and Geodon gave me tremendous brain fog. I felt zoned-out.


- Scott

 

Re: Ach(M) is this the dumb receptor

Posted by Pam DaMonium on January 14, 2004, at 23:44:16

In reply to Re: Ach(M) is this the dumb receptor, posted by SLS on January 14, 2004, at 21:44:42

Were you all neurophysiology majors? I do not know much about brain chemistry, but wish I did. Any suggestions other than attending med school?

Thanks for the tips!

 

Re: Ach(M) is this the dumb receptor

Posted by Interject79 on January 15, 2004, at 0:44:50

In reply to Ach(M) is this the dumb receptor, posted by linkadge on January 14, 2004, at 20:06:49

There are a few Ach muscarinic receptors. I imagine Zyprexa antagonises m1 at least, which should cause some cognitive slowing. Dopamine antagonism factors in as well. Zyprexa has a fairly long half-life too. The antipsychotics, even new ones, have to be used sparingly and only for a few conditions (e.g., schizophrenia, bipolar mania...). Sounds trivial, but for other uses the side effects might be intolerable.

Best,
interject

 

Re: Ach(M) is this the dumb receptor

Posted by rod on January 15, 2004, at 8:01:57

In reply to Ach(M) is this the dumb receptor, posted by linkadge on January 14, 2004, at 20:06:49

Youre confusing me. Isnt the Nicotinic Ach(N) receptor the one who is responsible for "thinking"? And the Muscarinic just responsible for e.g. dry mouth and constipation when blocked?

thanks in advance

Roland

 

Re: Ach(M) is this the dumb receptor

Posted by Interject79 on January 16, 2004, at 13:08:52

In reply to Re: Ach(M) is this the dumb receptor, posted by rod on January 15, 2004, at 8:01:57

Sorry to be confusing. Ach (N) antagonism in general does negatively impact cognitive performance, so I think the nicotinic Ach receptors are the 'cognition' ones primarily. You're right about this. But there are some muscarinic Ach receptors which, when antagonised, negatively impact cognition as well. I think M1, which Zyprexa antagonises, is one of these. I'm not certain, but I don't think Zyprexa does much to the nicotinic receptors. It's anticholinergic effects are muscarinic.

This might just confuse more. What we might think is that Zyprexa isn't as bad on cognition as it could be, with relation to acetylcholine. Dopamine's another issue...

Best,
interject



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