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Re: Ach(M) is this the dumb receptor

Posted by SLS on January 14, 2004, at 21:10:20

In reply to Ach(M) is this the dumb receptor, posted by linkadge on January 14, 2004, at 20:06:49

> I am looking at zyprexa, it has significant Ach(m) receptor activity. Is this the receptor that induces cognitive side effects ??
>

When antagonized, yes.

However, anticholinergic agents exert antidepressant effects for some people. Conversely (is that the right term in this case), pro-cholinergic drugs can induce depression. In my experience dosages of Zyprexa up to 10mg haven't really bothered me in the same way that imipramine does. I wouldn't make a decision about Zyprexa with anti-muscarinic properties as the criterion.

- Scott

 

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